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GSK3β identified as a driver of drug resistance in BRAF mutant melanoma

A new research perspective was published in Oncotarget, Volume 16, on April 4, 2025, titled "GSK3β activation is a key driver of resistance to Raf inhibition in BRAF mutant melanoma cells."

11 Apr 2025

Cholera cases in Europe linked to holy water imported from Ethiopia

Consumption of holy water from Ethiopia has recently led to several cases of cholera in Germany and the United Kingdom (UK) with a multidrug-resistant Vibrio cholerae strain, according to a study published in Eurosurveillance.

10 Apr 2025

Refining the diagnosis of large granular lymphocytic leukemias and their mimics

Large granular lymphocytic leukemias (LGLLs) are a heterogeneous group of rare chronic lymphoproliferative disorders characterized by the clonal proliferation of cytotoxic lymphocytes. Among them, T-cell LGLL (T-LGLL) and NK-cell LGLL (NK-LGLL) are the most prominent.

10 Apr 2025

New assay detects epigenetic changes caused by carcinogenic chemicals

Chemicals used as food preservatives, flavoring agents, dyes, pesticides, cosmetics, cleaners, and other industrial materials are being increasingly recognized as a health hazard.

10 Apr 2025

Breakthrough in chicken genomics offers hope against avian influenza

An international team of researchers led by Professor Huaijun Zhou from the UC Davis Department of Animal Science has created the first-ever detailed map of how genes are regulated in chickens - a breakthrough that could help scientists breed birds that are more resistant to diseases like avian influenza.

10 Apr 2025

Researchers uncover why fat gain happens fast during life changes

Perspective article proposes that major fat gains arise from short-term lifestyle disruptions rather than gradual daily surpluses. The authors call for public health strategies to focus on preventing episodic weight spikes during high-risk life events.

10 Apr 2025

Genetic test outperforms PSA and MRI in spotting deadly prostate cancer early

A UK study found that using a polygenic risk score to identify men at highest genetic risk of prostate cancer significantly improved detection of clinically important disease. This approach caught aggressive cancers that standard PSA and MRI screening would have missed.

10 Apr 2025

Researchers uncover a new genetic cause of neurodevelopmental disorders

A seminal study from researchers at the Icahn School of Medicine at Mount Sinai and their collaborators in the United Kingdom, Belgium, Spain, the Netherlands, and Iceland has uncovered a new genetic cause of neurodevelopmental disorders (NDDs).

10 Apr 2025

New study sharpens focus on genetic causes of asthma

Genome wide association studies (GWAS) have identified hundreds of genome regions containing thousands of genetic variants associated with asthma, but it's still not clear which variants have an actual causal link to the disease.

10 Apr 2025

Are food additives linked to type 2 diabetes?

This study identifies food additive mixtures associated with higher type 2 diabetes risk, urging a reevaluation of safety assessments for combined additives.

10 Apr 2025

Rapid growth of blood cancer driven by a single genetic ‘HIT’

A new study has unveiled when chronic myeloid leukaemia, a type of cancer that affects the blood and bone marrow, arises in life and how fast it grows.

10 Apr 2025

Largest study of osteoarthritis genetics uncovers new drug targets

Osteoarthritis is the leading cause of disability and chronic pain worldwide, affecting an estimated 595 million people globally.

9 Apr 2025

Breakthrough molecule offers hope for treating rare mitochondrial diseases

A medical breakthrough could result in the first treatment for rare but serious diseases in which genetic defects disrupt cellular energy production.

9 Apr 2025

Smaller hatching embryos more likely to be genetically healthy

A new research paper was published in Aging (Aging-US) Volume 17, Issue 3, on March 5, 2025, titled "Reproductive aging, preimplantation genetic testing for aneuploidy, and the diameter of blastocysts: does size matter?"

9 Apr 2025

Gut microbes and metabolites reveal how lifestyle changes help prevent type 2 diabetes

Researchers identified 502 blood metabolites linked to prediabetes and type 2 diabetes, with 143 tied to the gut microbiome. The study shows how lifestyle interventions like diet and exercise can modify metabolomic profiles to support glucose control.

9 Apr 2025

UCLA study identifies key protein driving kidney scarring

New UCLA research conducted using mouse models and human genetic data has uncovered a critical factor that determines how much scarring occurs following kidney injury, leading scientists to identify a potential precision medicine approach to prevent chronic kidney disease progression.

9 Apr 2025

Genetic fusion drives unexpectedly fast growth in chronic myeloid leukemia

A new study has unveiled when chronic myeloid leukemia, a type of cancer that affects the blood and bone marrow, arises in life and how fast it grows.

9 Apr 2025

Genetic breakthrough in psychiatry using long-read genomic sequencing

In a manuscript published today in the American Journal of Psychiatry titled Long-Read Genome Sequencing in Clinical Psychiatry: RFX3 Haploinsufficiency in a Hospitalized Adolescent With Autism, Intellectual Disability, and Behavioral Decompensation, authors describe how they leveraged long-read genomic sequencing (LRS) to make a genetic diagnosis in a17-year-old male with autism spectrum disorder, intellectual disability, and acute behavioral decompensation that would not have been possible by standard methods.

9 Apr 2025

Eating ultra-processed foods may rewire your brain’s hunger and reward circuits

High intake of ultra-processed foods is linked to adverse metabolic health and microstructural brain changes in regions that control appetite and reward. These effects occur both through obesity-related pathways and independently via inflammation and dyslipidemia.

9 Apr 2025

New STITCHR tool offers a promising step forward for gene therapy

Investigators from Mass General Brigham and Beth Israel Deaconess Medical Center have developed STITCHR, a new gene editing tool that can insert therapeutic genes into specific locations without causing unwanted mutations.

9 Apr 2025