Pathology News and Research

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Pathology is the study and diagnosis of disease through examination of organs, tissues, bodily fluids, and whole bodies (autopsies). The term also encompasses the related scientific study of disease processes, called General pathology. Medical pathology is divided in two main branches, Anatomical pathology and Clinical pathology. Veterinary pathology is concerned with animal disease whereas Phytopathology is the study of plant diseases.

Benefits and Challenges for XpressAmp™ Direct Amplification Reagents

News-Medical interviews Curtis Knox, Sr Strategic Portfolio Manager at Promega, about using the XpressAmp™ for the direct amplification of reagents.

From Promega Corporation 15 Jun 2021

Researchers study what happens in brain cells affected by Alzheimer's disease

Studies on tissue from patients and mini-brains made from stem cells shed light on the disease.

14 Jun 2021

Virginia Tech researcher receives $2.2 million to advance study on small 'fat burning' molecules

The liver is the most resilient organ in the human body. It can remove toxins from the bloodstream, recycle red blood cells, maintain sugar levels, and it can even regenerate itself. But, when a large amount of fat builds up in the liver, it becomes too inflamed to perform its crucial duties.

14 Jun 2021

USC study suggests new treatment target for Alzheimer's disease in people with APOE4 gene

Like amyloid plaque, the genetic variant APOE4 has long been associated with Alzheimer's disease, but still little is known about the role the gene plays in the disease process.

14 Jun 2021

New mathematical model helps simulate progression of age-related macular degeneration

Researchers from the Universidad Carlos III de Madrid (UC3M) have created a mathematical model and simulated numerically the progression of age-related macular degeneration, one of the main causes of blindness.

14 Jun 2021

Intranasal monoclonal SARS-CoV-2 antibody therapy shows promise in preclinical trials

A new study, released as a preprint on the bioRxiv* server, presents a new monoclonal antibody (MAb) called DZIF-10c that powerfully neutralizes SARS-CoV-2, including the current variants of concern (VOCs). With high bioavailability in the lungs and wide distribution in the body, the antibody was able to prevent SARS-CoV-2 infection in mice after intranasal administration.

14 Jun 2021

AI identifies gene signatures to reveal patients’ immune responses to viral infection

Researchers at University of California San Diego School of Medicine used an artificial intelligence (AI) algorithm to sift through terabytes of gene expression data -- which genes are "on" or "off" during infection -- to look for shared patterns in patients with past pandemic viral infections, including SARS, MERS and swine flu.

11 Jun 2021

Metformin prevents pulmonary or lung inflammation in animals infected with SARS-CoV-2

Metformin is a widely prescribed blood sugar-lowering drug. It is often used as an early therapy (in combination with diet and lifestyle changes) for type 2 diabetes, which afflicts more than 34 million Americans.

11 Jun 2021

Study: cis P-tau is an early marker of vascular dementia, Alzheimer's disease

Researchers remain perplexed as to what causes dementia and how to treat and reverse the cognitive decline seen in patients.

11 Jun 2021

Ketogenic metabolic therapy could work synergistically with IDH1-mutant glioblastoma

A British man who rejected the standard of care to treat his brain cancer has lived with the typically fatal glioblastoma tumor growing very slowly after adopting a ketogenic diet, providing a case study that researchers say reflects the benefits of using the body's own metabolism to fight this particularly aggressive cancer instead of chemo and radiation therapy.

11 Jun 2021

AMP’s new consensus can promote standardization of PGx gene/allele testing, improve patient care

The Association for Molecular Pathology (AMP), the premier global, molecular diagnostic professional society, today published consensus recommendations to aid in the design and validation of clinical CYP2D6 assays, promote standardization of testing across different laboratories and improve patient care

11 Jun 2021

Innovative protocol that processes saliva samples before testing may improve COVID-19 detection

The collection of nasopharyngeal swab (NPS) samples for COVID-19 diagnostic testing poses challenges including exposure risk to healthcare workers and supply chain constraints. Saliva samples are easier to collect but can be mixed with mucus or blood, and some studies have found they produce less accurate results.

10 Jun 2021

New data underscores the benefits of 360 smart bed platform at SLEEP 2021 annual meeting

Today, Sleep Number Corporation, a leader in sleep health, innovation, science and research, presented data as posters from two new studies using its 360® smart bed at SLEEP 2021, the 35th annual meeting of the Associated Professional Sleep Societies, LLC from June 10 to 13.

10 Jun 2021

Eldelumab and Fenofibrate show potential for COVID-19

In a new study posted to the medRxiv* preprint server, researchers from the University of Pittsburgh and Barrow Neurological Institute report the results of their analysis of several RNA-Seq studies and used computational approaches to discover potential drugs against COVID-19.

10 Jun 2021

New X-ray scanner could revolutionize cancer surgery, pathology, drug inspection

Engineers at Duke University have demonstrated a prototype X-ray scanning machine that reveals not just the shape of an object but its molecular composition. With unprecedented resolution and accuracy, the technology could revolutionize a wide range of fields such as cancer surgery, pathology, drug inspection and geology.

9 Jun 2021

Researchers find brain alterations in obese children

Obesity is generally linked to poor eating habits and the availability of tasty, high-calorie foods. However, a new study led by researchers from the Magnetic Resonance Imaging Research Unit in the Department of Radiology at Hospital del Mar and the Barcelona Institute for Global Health, a center supported by the "la Caixa" Foundation, has found that more elements are involved.

9 Jun 2021

DNA on-off switches for SARS-CoV-2 host receptor as potential therapeutic targets

Researchers in the United States and Canada have identified DNA on/off “switches” within the angiotensin-converting enzyme 2 (ACE2) gene that may control the expression of this host cell receptor before, during and after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

9 Jun 2021

Pathogenic airway neutrophilia drives ARDS in Black patients with severe COVID-19 in case study

Researchers from the US used a systems immunology approach where they combined high-dimensional flow cytometry and multi-omics single-cell sequencing analyses of immune profiles taken from the airways and matching blood samples of Black/AA patients.

9 Jun 2021

Physiotherapy program that uses Nintendo Wii console improves functionality, balance of stroke patients

A study by the Faculty of Physiotherapy of the University of Valencia (UV), in collaboration with the Autonomous University of Madrid, has shown that a physiotherapy programme that uses the Nintendo Wii console improves the functionality, balance and daily activities of patients who have suffered a cerebrovascular accident or stroke.

9 Jun 2021

Research reveals a possible new approach to prevent death among elderly COVID-19 patients

New research from the University of Minnesota Medical School and colleagues at the Mayo Clinic reveals a possible new approach to preventing death and severe disease in elderly people infected with SARS-CoV-2.

8 Jun 2021

Pathology News and Research

Further Reading

Benefits and Challenges for XpressAmp™ Direct Amplification Reagents

Researchers study what happens in brain cells affected by Alzheimer's disease

Virginia Tech researcher receives $2.2 million to advance study on small 'fat burning' molecules

USC study suggests new treatment target for Alzheimer's disease in people with APOE4 gene

New mathematical model helps simulate progression of age-related macular degeneration

Intranasal monoclonal SARS-CoV-2 antibody therapy shows promise in preclinical trials

AI identifies gene signatures to reveal patients’ immune responses to viral infection

Metformin prevents pulmonary or lung inflammation in animals infected with SARS-CoV-2

Study: cis P-tau is an early marker of vascular dementia, Alzheimer's disease

Ketogenic metabolic therapy could work synergistically with IDH1-mutant glioblastoma

AMP’s new consensus can promote standardization of PGx gene/allele testing, improve patient care

Innovative protocol that processes saliva samples before testing may improve COVID-19 detection

New data underscores the benefits of 360 smart bed platform at SLEEP 2021 annual meeting

Eldelumab and Fenofibrate show potential for COVID-19

New X-ray scanner could revolutionize cancer surgery, pathology, drug inspection

Researchers find brain alterations in obese children

DNA on-off switches for SARS-CoV-2 host receptor as potential therapeutic targets

Pathogenic airway neutrophilia drives ARDS in Black patients with severe COVID-19 in case study

Physiotherapy program that uses Nintendo Wii console improves functionality, balance of stroke patients

Research reveals a possible new approach to prevent death among elderly COVID-19 patients

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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