Molecule News and Research

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Using DNA droplets for early disease detection

Aqueous droplet formation by liquid-liquid phase separation (or coacervation) in macromolecules is a hot topic in life sciences research.

3 Jun 2022

A non-coding RNA molecule regulates mitochondrial gene expression in human cells, study shows

A new study published in the journal Cell shows that a non-coding RNA molecule regulates mitochondrial gene expression in human cells.

2 Jun 2022

Genetically engineered immune cells target cancer cells that may be responsible for leukemia relapse

Genetically engineered immune cells successfully target the specific cancer cells that may be responsible for relapse of acute myeloid leukemia (AML), a type of blood cancer, and proved effective in animal models of the disease, according to a preclinical study by investigators at Weill Cornell Medicine.

2 Jun 2022

New compound shows promise to kill a range of hard-to-treat cancer types

A compound, developed by a team including scientists from The University of Texas Health Science Center at San Antonio, kills a range of hard-to-treat cancer types in petri dishes and animal models by targeting a previously unexploited vulnerability, a new study reports.

2 Jun 2022

Collaborative effort uncovers a new type of triterpenes

A remarkable discovery and collaborative effort have revealed a new type of triterpenes, a group of organic compounds which are an important source of many medicines.

1 Jun 2022

New "masked" version of immunotherapy could help fight cancer without causing side effects

Many cancer treatments are notoriously savage on the body; they attack healthy cells at the same time as tumor cells, causing a plethora of side effects.

1 Jun 2022

Inhibiting immune response-related enzyme holds promise in preventing or treating severe COVID-19

Blocking an immune response-related enzyme holds promise in preventing or treating severe COVID-19 symptoms by reducing inflammation, tissue injury and blood clots in the lungs, new research in mice suggests.

1 Jun 2022

Study shows the SARS-CoV-2 accessory protein ORF7a inhibits HLA-I surface expression levels in human cells

Researchers identified a single viral gene product, the accessory factor ORF7a, facilitating SARS-CoV-2 immune evasion by downregulating the surface expression of MHC class I molecules.

1 Jun 2022

New study demonstrates the collapse of coalitions in microbial ecosystems

Government coalitions often dissolve when too many parties disagree on too many issues. Even if a coalition seems stable for some time, a small crisis can cause a chain reaction that eventually causes the system to collapse.

31 May 2022

UCLA researchers identify a method to make tumors susceptible to immune attack

One powerful way cancer cells defend against tumor-killing immune cells is to load up their cell surface with a protein known as PD-L1. Now a team of UCLA Jonsson Comprehensive Cancer Center researchers led by Roger S. Lo, MD, PhD, has identified a method to degrade tumor cell-surface PD-L1, thereby making tumors susceptible to immune attack.

31 May 2022

New compounds for cancer immunotherapy via STING-mediated immune activation

Innovations in cancer immunotherapy have achieved clinical success by considerably increasing the survival rate of patients undergoing cancer treatment.

31 May 2022

Understanding transposons provides a new starting point to generate more powerful gene editing tools

CRISPR has ushered in the era of genomic medicine. A line of powerful tools has been developed from the popular CRISPR-Cas9 to cure genetic diseases.

27 May 2022

Diabetes drug can improve the efficiency and efficacy of antibacterial treatments

Old dogs may not learn new tricks, but old drugs can, according to a research team based in China. The collaboration found that Metformin, a small molecule drug that has been used to treat type II diabetes for more than 50 years, can improve the efficiency and efficacy of antibacterial treatments for quick wound-healing in mice.

27 May 2022

New therapeutic approach harnesses the body's immune system to protect against brain damage

A therapeutic method for harnessing the body's immune system to protect against brain damage is published today by researchers from the Babraham Institute's Immunology research program.

27 May 2022

New approach could treat brain tumors and also prevent or delay recurrences

Scientists at the University of Michigan Rogel Cancer Center were optimistic when they identified a small molecule that blocked a key pathway in brain tumors.

27 May 2022

Scientists unlock a new approach to kill hard-to-treat cancers

In a paper appearing in Nature today, an international group of scientists have unlocked a new way to kill hard to treat cancers. These tumors resist current immunotherapies, including those using Nobel Prize winning check-point blocking antibodies.

26 May 2022

Ketamine uses a previously unknown pathway to produce an antidepressant effect, study finds

For the 280 million people suffering from depression globally, relief cannot come fast enough. Monoaminergic antidepressants, including selective serotonin reuptake inhibitors (SSRIs) take weeks to months to take effect and do not work for more than one in three patients.

26 May 2022

UCLA researchers discover key molecular mechanism behind memory linking

Our brains rarely record single memories - instead, they store memories into groups so that the recollection of one significant memory triggers the recall of others connected by time.

25 May 2022

Researchers discover mechanisms underlying T-cell receptor's immunosuppressive function

Investigators have discovered the mechanisms underlying a T-cell receptor's immunosuppressive function, according to a study published Nature Immunology, findings that may provide insight into the development of novel precision therapeutics for chronic diseases, including cancer.

25 May 2022

The role of pyroptosis in COVID-19

Researchers investigate the mechanisms by which SARS-CoV-2 induces NLRP3 inflammasome formation leading to pyroptosis.

25 May 2022

Molecule News and Research

Using DNA droplets for early disease detection

A non-coding RNA molecule regulates mitochondrial gene expression in human cells, study shows

Genetically engineered immune cells target cancer cells that may be responsible for leukemia relapse

New compound shows promise to kill a range of hard-to-treat cancer types

Collaborative effort uncovers a new type of triterpenes

New "masked" version of immunotherapy could help fight cancer without causing side effects

Inhibiting immune response-related enzyme holds promise in preventing or treating severe COVID-19

Study shows the SARS-CoV-2 accessory protein ORF7a inhibits HLA-I surface expression levels in human cells

New study demonstrates the collapse of coalitions in microbial ecosystems

UCLA researchers identify a method to make tumors susceptible to immune attack

New compounds for cancer immunotherapy via STING-mediated immune activation

Understanding transposons provides a new starting point to generate more powerful gene editing tools

Diabetes drug can improve the efficiency and efficacy of antibacterial treatments

New therapeutic approach harnesses the body's immune system to protect against brain damage

New approach could treat brain tumors and also prevent or delay recurrences

Scientists unlock a new approach to kill hard-to-treat cancers

Ketamine uses a previously unknown pathway to produce an antidepressant effect, study finds

UCLA researchers discover key molecular mechanism behind memory linking

Researchers discover mechanisms underlying T-cell receptor's immunosuppressive function

The role of pyroptosis in COVID-19

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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