Therapeutics News and Research

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Paxlovid has been free so far. Next year, sticker shock awaits.

Nearly 6 million Americans have taken Paxlovid for free, courtesy of the federal government. The Pfizer pill has helped prevent many people infected with covid-19 from being hospitalized or dying, and it may even reduce the risk of developing long covid.

7 Dec 2022

Research extends the powerful tool of immunotherapy to autoimmune diseases

The cancer therapy known as CAR-T has revolutionized treatment of some blood cancers since it was introduced in 2017. The therapy uses genetically altered immune cells to home in on cancer cells and destroy them.

6 Dec 2022

Innovative precision oncology enabled by micro-organospheres derived from patients

The development of an automatic microfluidics droplet platform to rapidly generate patient-derived models of cancer.

6 Dec 2022

Unique technology uses ultrasound-responsive nanobubbles for treating osteoporosis

University of Central Florida researchers have created unique technology for treating osteoporosis that uses nanobubbles to deliver treatment to targeted areas of a person's body.

6 Dec 2022

Study suggests new anti-KRAS drug as a strong candidate for pancreatic cancer clinical trials

A small molecule inhibitor that attacks the difficult to target, cancer-causing gene mutation KRAS, found in nearly 30 percent of all human tumors, successfully shrunk tumors or stopped cancer growth in preclinical models of pancreatic cancer, researchers from Penn Medicine's Abramson Cancer Center showed, suggesting the drug is a strong candidate for clinical trials.

6 Dec 2022

Higher dose of new antimalarial drug reduces disease recurrence by 85%

A new antimalarial drug is being introduced at a dose that is too low to be effective for all patients who need it, according to a report published today in eLife.

6 Dec 2022

Research explores how alignment of endothelial cells plays a role in cancer metastasis

Preventing metastasis – the development of cancer cells beyond their original location – remains one of the major goals of current cancer research.

6 Dec 2022

NIHTB-CB tests found to be sensitive in detecting cognitive change in people with intellectual disability

A major challenge in testing new therapies for people with intellectual disability is finding accurate tools to measure whether the intervention or medication works.

5 Dec 2022

New trial to evaluate a potential treatment for irritability in teenagers with autism

A new trial will test whether a medication that targets gut bacteria can also improve irritability in teenagers with autism spectrum disorder.

5 Dec 2022

Hepatitis B virus haplotype number is a predictive marker of functional cure during antiviral therapies

Patients with a lower hepatitis B virus haplotype number are more likely to achieve a functional cure with chronic hepatitis B treatment.

4 Dec 2022

Klick scientists use machine learning and 12 hours of CGM data to predict diabetes onset

Scientists at Klick Applied Sciences have discovered a way to transform a continuous glucose monitor (CGM) into a powerful diabetes screening and prevention tool using artificial intelligence.

2 Dec 2022

New tool may help better predict resistance to immunoglobulin therapy among children with Kawasaki disease

predict resistance to immunoglobulin therapy among children with Kawasaki disease in the United States.

2 Dec 2022

Sharp increase in B cell population can prevent intestinal healing

B cells are critical to the proper functioning of the immune system. However, researchers at Karolinska Institutet have shown that they can sometimes do more harm than good, as their numbers greatly increase after bowel damage, preventing the tissue from healing.

2 Dec 2022

Scaling up the production of customized immune cells for drug development and testing

To prevent testing on animals and create even more precise ways of testing therapeutics, the pharmaceutical industry is increasingly turning to human immune cells.

1 Dec 2022

Research shows biological sex as a crucial factor in the effectiveness of anti-aging drugs

The effect of medicines on women and men can differ significantly. This also applies to the currently most promising anti-aging drug rapamycin, as researchers from the Max Planck Institute for Biology of Ageing in Cologne and University College London have now shown.

1 Dec 2022

Integrated approach addresses some of the biggest challenges in natural products drug discovery

Many successful drugs have their origins in natural sources such as plants, fungi, and bacteria, but screening natural products to identify potential drugs remains a difficult undertaking.

1 Dec 2022

Study implicates a specific type of brain cell as key player underlying the impact of stressors

More than 70% of adults will experience at least one traumatic experience, such as a life-threatening illness or accident, violent assault or natural disaster, in their lifetimes and nearly a third will experience four or more, according to global data.

1 Dec 2022

Detection of filoviruses by the innate immune system

In a new study, researchers examined how the innate immune system detects filoviruses.

1 Dec 2022

Hyperactivated brain cells following social trauma impair social reward and promote social avoidance

Past social trauma is encoded by a population of stress/threat-responsive brain cells that become hyperactivated during subsequent interaction with non-threatening social targets. As a consequence, previously rewarding social targets are now perceived as social threats, which promotes generalized social avoidance and impaired social reward processing that can contribute to psychiatric disorders, according to a study conducted by researchers at the Brain and Body Research Center at Mount Sinai and published November 30 in Nature.

30 Nov 2022

Study reveals key details of how DREADD technology highjacks neuronal activity

Understanding of how neuronal activity modulates brain function is a key first step towards creating more effective drugs to treat a variety of neuropsychiatric illnesses, including depression, anxiety, schizophrenia, substance abuse, epilepsy, and others.

30 Nov 2022

Therapeutics News and Research

Paxlovid has been free so far. Next year, sticker shock awaits.

Research extends the powerful tool of immunotherapy to autoimmune diseases

Innovative precision oncology enabled by micro-organospheres derived from patients

Unique technology uses ultrasound-responsive nanobubbles for treating osteoporosis

Study suggests new anti-KRAS drug as a strong candidate for pancreatic cancer clinical trials

Higher dose of new antimalarial drug reduces disease recurrence by 85%

Research explores how alignment of endothelial cells plays a role in cancer metastasis

NIHTB-CB tests found to be sensitive in detecting cognitive change in people with intellectual disability

New trial to evaluate a potential treatment for irritability in teenagers with autism

Hepatitis B virus haplotype number is a predictive marker of functional cure during antiviral therapies

Klick scientists use machine learning and 12 hours of CGM data to predict diabetes onset

New tool may help better predict resistance to immunoglobulin therapy among children with Kawasaki disease

Sharp increase in B cell population can prevent intestinal healing

Scaling up the production of customized immune cells for drug development and testing

Research shows biological sex as a crucial factor in the effectiveness of anti-aging drugs

Integrated approach addresses some of the biggest challenges in natural products drug discovery

Study implicates a specific type of brain cell as key player underlying the impact of stressors

Detection of filoviruses by the innate immune system

Hyperactivated brain cells following social trauma impair social reward and promote social avoidance

Study reveals key details of how DREADD technology highjacks neuronal activity

Industry Focus eBook - Microbiome (1st edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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