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New insights into molecular mechanisms that underpin the body's natural defenses against skin cancer

A study published today in Cell Reports reveals important insights into the molecular mechanisms that underpin the body's natural defenses against the development of skin cancer.

11 Jan 2022

Novel mechanisms controlling tertiary lymphoid structure formation in tumors revealed

Tertiary lymphoid structures are formations that occur outside of the lymphatic system. They contain immune cells and are similar in structure and function to lymph nodes and other lymphoid structures.

11 Jan 2022

VarLOCK approach for rapid detection of SARS-CoV-2 variants of concern and wastewater monitoring

A recent study discussed the expansion of the SARS-CoV-2 CRISPR-Cas detection technology (SHERLOCK) into Variant-specific SHERLOCK (VarLOCK) assays to accurately differentiate between the newly emerging SARS-CoV-2 variants of concern.

11 Jan 2022

Unraveling the early host-immune response to SARS-CoV-2 in mild COVID-19 infections

In a new study, researchers determined the early immune response to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) during mild coronavirus disease 2019 (COVID-19) in rhesus macaques.

11 Jan 2022

Exploring the kinetics of SARS-CoV-2 Marseille-4 variant

In a new study, researchers determined the nature and dynamics of mutations associated with the SARS-CoV-2 French Marseille-4 variant during 10 months from its onset, and concluded that the heterogenicity associated with a SARS-CoV-2 lineage can possibly predict the end of an outbreak.

11 Jan 2022

Study reveals genomic regions that could help understand obesity

A new study has helped to shine light on the genetic pathways underlying obesity. The findings could help develop more personalized ways to help people maintain a healthy weight.

11 Jan 2022

Modular super-enhancer regulates gene expression involved in retina development

Enhancers are regions of DNA that do not code for proteins, but control how genes are expressed. Super-enhancers are clusters of enhancers that together regulate genes with important roles in cell identity.

11 Jan 2022

New insights into reforming the actions that hindered Seattle researchers from community testing for COVID-19

As the two-year anniversary of the pandemic approaches, a new commentary provides insights into reforming the "labyrinth of conflicting and uncoordinated actions among state and federal regulators" that in early 2020 hampered Seattle researchers from community testing for COVID-19.

11 Jan 2022

Researchers identify gene expression signatures linked to suicide risk

Is risk of suicide in our genes? Findings of an international scientific team led by the Translational Genomics Research Institute (TGen), an affiliate of City of Hope, suggest that gene expression studies could offer insights into the underlying causes of suicide, a highly complex public health problem that takes the lives of more than 800,000 people each year worldwide.

10 Jan 2022

New lab-on-a-chip platform for detecting SARS-CoV-2 in resource-limited settings

A recent study shows how a novel and integrated lab-on-a-chip platform can represent a rapid, affordable, and exact molecular diagnostic tool for detecting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The paper is currently available for free on the medRxiv* preprint server while it undergoes peer review.

9 Jan 2022

Emerging SARS-CoV-2 B.1.619 and B.1.620 variants in South Korea

Researchers investigate the spread and transmission ability of SARS-CoV-2 lineages B.1.619 and B.1.620 in South Korea.

9 Jan 2022

Composition of poplar tree microbiome changes dramatically over time, study finds

Recent work shows that the plant microbiome - the microorganisms in a plant and its immediate environment - influences plant health, survival, and fitness. The initial assembly of the microbiome is particularly important.

9 Jan 2022

Researchers isolate Omicron variant, leveling the path to vaccine development and vaccine efficacy studies

Researchers from India have now successfully grown and isolated the Omicron variant from hamsters in vivo with further culturing in the Vero CCL-81 cells in vitro, in a step forward towards testing the effectiveness of existing SARS-CoV-2 vaccines and generation of new Omicron appropriate vaccines.

7 Jan 2022

SARS-CoV-2 Omicron less pathogenic in hamsters

A new research paper posted as a preprint to the bioRxiv* server attempts to throw some light on this question by studying viral pathogenicity in golden hamsters, a valuable model for severe COVID-19 due to the development of reproducible weight loss and pneumonia after infection with the virus.

6 Jan 2022

Study reinforces the link between microglia and some cases of brain disease

Certain subtle differences in DNA sequences are known to raise the chances a person may develop Alzheimer's or Parkinson's disease.

6 Jan 2022

Emergence of a new SARS-CoV-2 variant from Southern France

A new study has described the emergence of another new SARS-CoV-2 variant from south-eastern France with Cameroonian origin.

6 Jan 2022

Comparison of neutralization of SARS-CoV-2 variants of concern Omicron and Delta

The purpose of this study was to determine the breadth of neutralizing activity generated by exposure to certain SARS-CoV-2 variants, vaccinations, or both.

6 Jan 2022

New method to estimate how individual mutations affect transmission of SARS-CoV-2

A new study, posted to the medRxiv* preprint server, constructs an analytical SIR-based epidemiological model to analyze the effects of mutations on SARS-CoV-2 transmission from genomic surveillance data.

5 Jan 2022

Impact of delaying the lifting of SARS-CoV-2 lockdown restrictions

New study findings provided critical insights into competitive behavior and the relative transmissibility of SARS-CoV-2 variants, which could be used for planning responses to future emerging variants and exploring co-infections with different strains of SARS-CoV-2 and influenza virus.

5 Jan 2022

Comparison of the mutational profile of Omicron with other SARS-CoV-2 lineages

Researchers from nference labs in Massachusetts have been examining the origins of a particular mutation in the Omicron variant.

5 Jan 2022

Genomic News and Research

New insights into molecular mechanisms that underpin the body's natural defenses against skin cancer

Novel mechanisms controlling tertiary lymphoid structure formation in tumors revealed

VarLOCK approach for rapid detection of SARS-CoV-2 variants of concern and wastewater monitoring

Unraveling the early host-immune response to SARS-CoV-2 in mild COVID-19 infections

Exploring the kinetics of SARS-CoV-2 Marseille-4 variant

Study reveals genomic regions that could help understand obesity

Modular super-enhancer regulates gene expression involved in retina development

New insights into reforming the actions that hindered Seattle researchers from community testing for COVID-19

Researchers identify gene expression signatures linked to suicide risk

New lab-on-a-chip platform for detecting SARS-CoV-2 in resource-limited settings

Emerging SARS-CoV-2 B.1.619 and B.1.620 variants in South Korea

Composition of poplar tree microbiome changes dramatically over time, study finds

Researchers isolate Omicron variant, leveling the path to vaccine development and vaccine efficacy studies

SARS-CoV-2 Omicron less pathogenic in hamsters

Study reinforces the link between microglia and some cases of brain disease

Emergence of a new SARS-CoV-2 variant from Southern France

Comparison of neutralization of SARS-CoV-2 variants of concern Omicron and Delta

New method to estimate how individual mutations affect transmission of SARS-CoV-2

Impact of delaying the lifting of SARS-CoV-2 lockdown restrictions

Comparison of the mutational profile of Omicron with other SARS-CoV-2 lineages

Industry focus eBook: Genomics (4th edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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