Biochemistry News and Research

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New cellular entry pathway improves gene therapy outcomes

Scientists from the Centenary Institute and the University of Sydney have made a landmark discovery that could lead to safer and more effective gene therapies for a range of serious genetic disorders including Duchenne muscular dystrophy, Pompe disease and hemophilia.

15 Jul 2025

Nighttime pistachio consumption affects gut bacteria in adults with prediabetes

Prediabetes affects a third of people in the United States and most of them will develop Type 2 diabetes, yet effective dietary intervention strategies remain limited.

14 Jul 2025

Hydrogels could be key to safer, smarter cancer drug delivery

Hydrogels could revolutionize cancer treatment by facilitating targeted drug delivery, reducing adverse effects, and enhancing therapeutic effectiveness.

11 Jul 2025

Mitochondria and peroxisomes work together to defend against cell damage

An international team led by researchers at The Hospital for Sick Children (SickKids), Princess Margaret Cancer Centre, Dalhousie University, the University of Exeter (UK) and the Medical University of Vienna (Austria) has uncovered a surprising way compartments within cells work together to defend themselves against oxidative stress, a finding that could shift how we understand age-associated conditions such as diabetes and neurodegenerative diseases.

10 Jul 2025

How hydrogels are shaping the future of targeted cancer drug delivery

A large-scale bibliometric analysis maps global research on hydrogels as next-generation drug delivery systems for cancer therapy. The study highlights emerging trends, key contributors, and future directions to advance precision medicine in oncology.

10 Jul 2025

The Proteoform Puzzle: Unlocking the Next Frontier

In the interview, Lloyd M. Smith discusses proteoforms, an area of research worthy of the next Human Genome Project.

From Pittcon 10 Jul 2025

AlphaFold2 enables large scale analysis of enzyme evolution

Enzymes catalyze chemical reactions in organisms - without which life would not be possible. Leveraging AlphaFold2 artificial intelligence, researchers at Charité – Universitätsmedizin Berlin have now succeeded in analyzing the laws of their evolution on a large scale.

10 Jul 2025

Researchers use cryo-EM to map Powassan virus structure at high resolution

As summer kicks into full gear and people are spending more time outside, there's one thing on many people's minds - ticks.

9 Jul 2025

Experimental treatment reverses paralysis in child with rare mitochondrial disease

The value of a recent biochemical discovery can be seen in the case of an 8-year-old boy. In August 2023 he was able to play typical sports, but by November he needed a wheelchair because of a rare disease that caused worsening paralysis.

9 Jul 2025

Healthy plant-based diet linked with reduced risk of inflammatory bowel disease

A large prospective study published in Molecular Nutrition and Food Research reveals that a healthy plant-based diet is linked with a reduced risk of inflammatory bowel disease.

9 Jul 2025

Energy waves on cancer cell surfaces linked to tumor growth and aggressiveness

In a bid to better understand how cancer cells power their explosive growth and spread, scientists at Johns Hopkins Medicine say they have shed new light on the location and function of power-generating waves on the covering, or membrane, of these cells.

9 Jul 2025

New RNA-based liquid biopsy detects early colorectal cancer with high accuracy

Liquid biopsies are tests that detect signs of cancer through a simple blood draw. Unlike traditional biopsies, which require removing a piece of tissue, a liquid biopsy typically looks for mutations or modification changes in fragments of DNA from cancer cells circulating in the blood.

8 Jul 2025

Long-term study confirms lasting benefits of lifestyle changes in preventing diabetes

In the early 2000s the U.S. Diabetes Prevention Program (DPP), a large randomized clinical trial, showed that intensive lifestyle modification was better than a medication called metformin at preventing at-risk patients from developing Type 2 diabetes.

3 Jul 2025

Breakthrough study questions longstanding STING activation approach

Researchers have long focused on the STING (Stimulator of Interferon Genes) pathway as a way to harness the immune system's natural defenses against cancer.

3 Jul 2025

Targeting a key enzyme could reverse early Parkinson's effects

Putting the brakes on an enzyme might rescue neurons that are dying due to a type of Parkinson's disease that's caused by a single genetic mutation, according to a new Stanford Medicine-led study conducted in mice.

2 Jul 2025

Brain cells can burn fat to fuel activity

While glucose, or sugar, is a well-known fuel for the brain, Weill Cornell Medicine researchers have demonstrated that electrical activity in synapses—the junctions between neurons where communication occurs—can lead to the use of lipid or fat droplets as an energy source.

1 Jul 2025

Macrophage-derived lipocalin 2 drives severe pneumonia in SARS-CoV-2 infection

Since the emergence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), understanding the mechanisms underlying severe pneumonia has remained a major research challenge.

1 Jul 2025

Glycogen metabolism in neurons emerges as key to fighting Alzheimer's

A new study from scientists at the Buck Institute for Research on Aging has revealed a surprising player in the battle against Alzheimer's disease and other forms of dementia: brain sugar metabolism.

1 Jul 2025

New yeast model sheds light on proteasome and mitochondrial interaction

A study by the Center for Redox Processes in Biomedicine (Redoxoma) led by Marilene Demasi from the Butantan Institute (São Paulo, Brazil) presents a valuable new experimental model for investigating the interaction between the proteasome and mitochondrial function.

30 Jun 2025

Beetle-inspired tuberculosis testing device offers accurate detection for people with HIV

Current tuberculosis infection tests struggle to detect the disease in those with HIV. A common co-infection, HIV can hide TB from traditional tests by eliminating the immune cells relied upon to sound the alarm.

27 Jun 2025