Fatigue News and Research

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Fruit fly study reveals brain mechanism underlying motivation fatigue

Our brain's reward system processes and reinforces pleasurable experiences, motivating us to seek out and engage in rewarding activities ranging from eating to social interactions to recreational drug use.

20 Nov 2025

Global experts map out the practical steps that help extend life expectancy

The 1st World Longevity Summit in Kyotango, Japan brought together global experts to share advances in aging biology, lifestyle medicine, and community-based strategies for healthy longevity. Its joint declaration identified four pillars – social connection, plant-based diets, daily activity, and gratitude with purpose – as core foundations for extending healthy life expectancy worldwide.

19 Nov 2025

Middle-aged Australians experience the highest levels of stress, burnout and emotional fatigue

Middle-aged Australians are keeping the country running - but it's taking a hefty toll on their wellbeing, a new report shows.

19 Nov 2025

Daily berries and cocoa enhance mood by targeting key brain pathways

Dietary flavonoids from everyday foods show modest but promising benefits for mood, with the strongest evidence emerging from chronic, anthocyanin rich interventions. Acute effects are mixed, but longer term intake may support emotional well being through mechanisms involving monoamine activity and neuroplasticity.

17 Nov 2025

UCI Health launches clinical trial to test investigational cell therapy for lupus

UCI Health has opened a clinical trial to test an investigational cell therapy for lupus with the potential to give patients long-term remission of symptoms.

17 Nov 2025

Low-glutamate diet improves migraine symptoms in veterans with Gulf War Illness

Veterans with Gulf War Illness experienced significant improvement in migraine symptoms after following a diet low in glutamate, a component of flavor enhancing food additives commonly found in processed foods, according to new research presented by Georgetown University and American University scientists.

17 Nov 2025

Testing nicotinamide riboside as a potential aid for long COVID recovery

Chao-Yi Wu, PhD, OT, from the Department of Neurology and Edmarie Guzmán-Vélez, PhD, of the Department of Psychiatry at Mass General Brigham, are the lead and senior authors of a paper published in eClinicalMedicine, "Effects of Nicotinamide Riboside on NAD+ Levels, Cognition, and Symptom Recovery in Long-COVID: A Randomized Controlled Trial."

14 Nov 2025

Off-label GLP-1 use highlights the cultural pressures driving body anxieties

New obesity drugs that were designed to treat diabetes and obesity are increasingly being used off-label by people without these conditions to achieve slimness and social approval rather than health gains. This perspective maps how such pharmacological thinness interacts with stigma, beauty ideals, digital culture, and inequality, and calls for multinational, intersectional research to understand its full impact.

13 Nov 2025

New study identifies a "sweet spot" in clinical decision-making

Having more options is always better - until it's not. Doctors face this paradox daily when choosing treatment plans for patients, especially under the pressure of packed clinical schedules. Too few choices can limit care, but too many can lead to decision fatigue.

13 Nov 2025

Scientists discover hidden weakness in Lyme disease bacterium

For decades, Lyme disease has frustrated both physicians and patients alike. Caused by the corkscrew-shaped bacterium Borrelia burgdorferi, the infection, if left untreated, can linger for months, leading to fever, fatigue and painful inflammation.

13 Nov 2025

Study links common Epstein-Barr virus to autoimmune lupus

One of humanity's most ubiquitous infectious pathogens bears the blame for the chronic autoimmune condition called systemic lupus erythematosus or, colloquially, lupus, Stanford Medicine investigators and their colleagues have found.

12 Nov 2025

Hard water drives a surge in microplastic shedding from polyester, study finds

Researchers found that hand-washing in mineral-rich water dramatically increases microplastic fibre shedding from polyester fabrics, fragmenting fibres into shorter pieces. A two-layer PDMS coating sharply reduced shedding from green polyester but was far less effective on black polyester due to pre-existing surface finishes.

12 Nov 2025

Natural compound and exercise work together to enhance musculoskeletal health in aging bodies

A new research paper was published in Volume 17, Issue 10 of Aging-US on October 1, 2025, titled "L-β-aminoisobutyric acid (L-BAIBA) in combination with voluntary wheel running exercise enhances musculoskeletal properties in middle-age male mice."

11 Nov 2025

Study reveals how neural excitability and learning potential fluctuate across the day

Our brains do not react in a fixed, mechanical way like electronic circuits. Even if we see the same scene every day on our commute to work, what we feel - and whether it leaves a lasting impression - depends on our internal state at that moment.

11 Nov 2025

Single daily polypill improves heart function and quality of life in heart failure patients

Adults with heart failure with reduced ejection fraction (HFrEF) who took a "polypill" combining medications prescribed for the treatment of heart failure, had improved heart function and symptoms, better quality of life, fewer hospitalizations and greater medication adherence than those taking the medications individually, according to a late-breaking science presentation today at the American Heart Association's Scientific Sessions 2025.

10 Nov 2025

Study reveals double trouble for peripheral arterial disease patients with AFib

New research from Intermountain Health in Salt Lake City finds that patients diagnosed with peripheral arterial disease (PAD) who also have atrial fibrillation (AFib) face a significantly higher risk of major adverse cardiovascular events (MACE).

10 Nov 2025

New dietary supplement may efficiently treat iron deficiency and anemia

Iron deficiency is globally widespread. Women are particularly affected, with one in five in Europe suffering from iron deficiency.

10 Nov 2025

Study links dysautonomia to breathing problems in chronic fatigue patients

Chronic fatigue syndrome leaves patients exhausted and struggling with brain fog - and it typically gets worse after mental or physical exercise, a phenomenon called post-exertional malaise.

10 Nov 2025

One concussion can raise your car crash risk by nearly 50%

Research shows that concussions elevate the risk of motor vehicle crashes, particularly in the weeks following injury, necessitating enhanced safety measures.

10 Nov 2025

Beta-blockers offer no clinical benefit for myocardial infarction survivors with preserved cardiac function

A major analysis led by the Centro Nacional de Investigaciones Cardiovasculares (CNIC), in collaboration with international institutions, has pooled data from 17,801 myocardial infarction survivors with preserved cardiac function enrolled in five global clinical trials.

10 Nov 2025