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Combination therapy shows promising results in patients with recurrent ER-positive endometrial cancer

A combination therapy that targets cancer cells from within and without caused tumors to shrink or stabilize in 75% of patients with recurrent or persistent estrogen receptor- (ER-) positive endometrial cancer, results from a recent clinical trial show.

19 Mar 2022

Covalent protein nanobodies for neutralizing SARS-CoV-2 and its variants

Researchers developed covalent nanobodies to neutralize severe acute respiratory syndrome coronavirus-2 and its variants.

18 Mar 2022

Study evaluates COVID-19 vaccination with recombinant accessory protein-deficient SARS-CoV-2

Researchers assessed the impact of recombinant accessory protein-deficient severe acute respiratory syndrome coronavirus 2 immunization against SARS-CoV-2 transmission and disease severity.

18 Mar 2022

Hypoxia-inducible factors and SARS-CoV-2 manifestations

Researchers assessed the role of hypoxia-inducible factors in SARS-CoV-2 infection, respiratory symptoms, and epithelial damage.

18 Mar 2022

Study explores SARS-CoV-2 spike epitope with potent and broad neutralization

Researchers reported an epitope with high potency and breadth and demonstrated that a therapeutic antibody directed at this site neutralizes all SARS-CoV-2 variants.

18 Mar 2022

Why does the SARS-CoV-2 Omicron variant escape immunity?

Researchers reveal the underlying mechanism associated with the Omicron variant’s increased transmissibility and ability to evade immunity.

17 Mar 2022

RNA-chopping enzyme Dicer stabilizes mammalian chromosomes with the help of BRD4 activator

Cells use RNA as a versatile tool to regulate the activity of their genes. Small snippets of RNA can fine-tune how much protein is produced from various genes; some small RNAs can shut genes off altogether.

17 Mar 2022

Study reports thiopurines inhibit the replication of the betacoronaviruses HCoV-OC43 and SARS-CoV-2

Researchers demonstrated that the thiopurines block coronaviruses spike protein assembly and integration into progeny virions.

17 Mar 2022

Narrative review reports two important mediators in SARS-CoV-2-induced ischemic stroke recovery

Researchers explored neuroinflammation and COVID-19-induced ischemic stroke recovery.

17 Mar 2022

Study reports reduced disease severity in Syrian hamsters during re-infection with SARS-CoV-2 Delta variant

Researchers studied the immune responses in Syrian hamsters re-infected with SARS-CoV-2 Delta and B.1 variants three months after the primary infection.

17 Mar 2022

Researchers evaluate predictors for mortality in hospitalized COVID-19 patients

Researchers identified independent factors associated with early and late deaths in hospitalized COVID-19 patients.

17 Mar 2022

Biomarkers to identify SARS-CoV-2 patients requiring invasive mechanical ventilation

Researchers evaluated biomarkers that could help identify COVID-19 patients needing invasive mechanical ventilation.

17 Mar 2022

Novel fusion inhibitor blocks SARS-CoV-2 spike-mediated cell-cell fusion

Researchers constructed a novel fusion inhibitor−based recombinant protein, referred to as 5−Helix, to block SARS-CoV-2 spike-mediated cell-cell fusion.

17 Mar 2022

The immunogenicity of homologous and heterologous boosters in adults who received inactivated COVID-19 vaccine six months prior

Researchers compared the efficacy of booster doses of heterologous intramuscular and aerosolized adenovirus-vectored vaccine, a recombinant protein-based ZF2001 vaccine, and homologous CoronaVac vaccines.

17 Mar 2022

The safety and immunogenicity of NVSI-06-08 as a heterologous booster dose in adults previously vaccinated with BBIBP-CorV

Researchers assessed the safety profile and immunogenicity of a heterologous NVSI-06-08 boost against SARS-CoV-2 variants in individuals doubly vaccinated with the inactivated vaccine BBIBP-CorV.

17 Mar 2022

Frail and older males more vulnerable to COVID-19 than females

Researchers evaluated the association of biological sex, frailty, and age with the vaccine-elicited immunity against SARS-CoV-2.

17 Mar 2022

Novel metabolic mechanisms contribute to how ovarian cancer evades immune attack, research finds

High-grade serous carcinoma is the most aggressive form of ovarian cancer and accounts for the majority of advanced-stage cases.

16 Mar 2022

Study finds a promising new target for immunity-boosting cancer treatments

Tumors can use an enzyme called ART1 to thwart antitumor immune cells, making the enzyme a promising new target for immunity-boosting cancer treatments, according to a study from researchers at Weill Cornell Medicine and Albert Einstein College of Medicine.

16 Mar 2022

UQ researchers discover a molecule essential for regulating nerve repair

Researchers at The University of Queensland have identified a molecule essential for regulating the repair of injured nerves, which could help people recover from nerve damage.

16 Mar 2022

Placenta found to demonstrate anti-oxidant activity against COVID-19 in full-term pregnancy

Researchers assessed the placental anti-oxidant response in the third trimester of pregnancy against SARS-CoV-2 infections.

16 Mar 2022

Enzyme News and Research

Combination therapy shows promising results in patients with recurrent ER-positive endometrial cancer

Covalent protein nanobodies for neutralizing SARS-CoV-2 and its variants

Study evaluates COVID-19 vaccination with recombinant accessory protein-deficient SARS-CoV-2

Hypoxia-inducible factors and SARS-CoV-2 manifestations

Study explores SARS-CoV-2 spike epitope with potent and broad neutralization

Why does the SARS-CoV-2 Omicron variant escape immunity?

RNA-chopping enzyme Dicer stabilizes mammalian chromosomes with the help of BRD4 activator

Study reports thiopurines inhibit the replication of the betacoronaviruses HCoV-OC43 and SARS-CoV-2

Narrative review reports two important mediators in SARS-CoV-2-induced ischemic stroke recovery

Study reports reduced disease severity in Syrian hamsters during re-infection with SARS-CoV-2 Delta variant

Researchers evaluate predictors for mortality in hospitalized COVID-19 patients

Biomarkers to identify SARS-CoV-2 patients requiring invasive mechanical ventilation

Novel fusion inhibitor blocks SARS-CoV-2 spike-mediated cell-cell fusion

The immunogenicity of homologous and heterologous boosters in adults who received inactivated COVID-19 vaccine six months prior

The safety and immunogenicity of NVSI-06-08 as a heterologous booster dose in adults previously vaccinated with BBIBP-CorV

Frail and older males more vulnerable to COVID-19 than females

Novel metabolic mechanisms contribute to how ovarian cancer evades immune attack, research finds

Study finds a promising new target for immunity-boosting cancer treatments

UQ researchers discover a molecule essential for regulating nerve repair

Placenta found to demonstrate anti-oxidant activity against COVID-19 in full-term pregnancy

Measuring Drug-Target Residence Times with Biochemical Assays eBook

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