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Rice University scientists develop and evaluate analogs of potent cancer fighters

Rice University scientists have developed and evaluated analogs of potent anti-tumor agents known as epothilones using designs and methods that both improve their biological properties and simplify their manufacture.

31 May 2017

Drug rebates reward industry players — and often hurt patients

Medicare and its beneficiaries aren't the winners in the behind-the-scenes rebate game played by drugmakers, health insurers and pharmacy benefit managers, according to a paper published Tuesday in JAMA Internal Medicine.

30 May 2017

NCCN ORP funds researchers to evaluate targeted treatment in EGFRm+ non-small cell lung cancer

The National Comprehensive Cancer Network Oncology Research Program has funded two investigators from NCCN Member Institutions through a collaborative scientific research relationship with AstraZeneca to further evaluate the clinical effectiveness of osimertinib in the treatment of epidermal growth factor receptor-positive (EGFRm+) non-small cell lung cancer (NSCLC).

25 May 2017

BGU researchers redesign portion of FDA-approved drug into new molecule to treat ALS

Ben-Gurion University of the Negev researchers are developing a new therapy for Amyotrophic Lateral Sclerosis using part of an existing FDA-approved drug that restores the central nervous system's (CNS) immune defenses and increases life expectancy.

25 May 2017

SUNY Downstate researchers find three stressful work characteristics increasing in the U.S.

Researchers at SUNY Downstate Medical Center's School of Public Health have determined that two stressful work characteristics, low job control and "job strain" -- that is, high-demand, low-control work -- have been increasing in the U.S. since 2002.

24 May 2017

Researchers study connection between oxytocin and investment in couple relationships

LOVE HORMONE: Oxytocin is often called the "love hormone" or "cuddle chemical", but American and Norwegian researchers have found out that it may as well be called a "crisis hormone."

18 May 2017

Seventh Wave announces collaboration with Yecuris to study new liver disease therapies

Seventh Wave Laboratories, a consulting-based contract research organization that assesses the safety and efficacy of pharmaceutical products and medical devices, has announced an exclusive collaboration with Yecuris Corporation, a global leader in the development and use of humanized models in drug development research.

18 May 2017

WPI research program aims to understand gender differences in neurobiology

Many complicated neurological disorders appear to have a gender bias. Women, for example, are more likely to develop Alzheimer's disease, while men are at greater risk for Parkinson's disease.

17 May 2017

Spanish scientists develop promising gene therapy method to treat Wilson's disease

Scientists at the Center for Applied Medical Research at the University of Navarra have designed a promising gene therapy method to treat Wilson's disease, a rare pathology caused by the lack of or malfunction of a gene.

16 May 2017

Researchers identify many dangerous strains of TB pathogens

Researchers from the Vavilov Institute of General Genetics of the Russian Academy of Sciences (VIGG) and the Moscow Institute of Physics and Technology have established a catalog of mutations in 319 virulence genes of mycobacteria that cause tuberculosis.

16 May 2017

Breast cancer cells undergo stiffening state prior to becoming malignant, study shows

A study published now on Nature Communications shows that breast cancer cells undergo a stiffening state prior to acquiring malignant features and becoming invasive.

16 May 2017

New approach could help improve management decisions during Ebola outbreak

A new approach to information gathering could allow scientists to quickly identify the most effective way to manage a disease outbreak, an advance that could save lives.

16 May 2017

New research could lead to earlier diagnosis and better management of inflammatory bowel disease

A University of Manchester test on the mucus lining of the intestine, performed in mice, has found changes in bacteria that could lead to inflammatory bowel disease 12 weeks earlier than previously possible through looking at stool samples, leading to the possibility of earlier diagnosis and better management of the disease in humans.

From The University of Manchester 15 May 2017

Phase 1 clinical studies reveal safety, tolerability of therapeutic vaccine in celiac disease patients

ImmusanT, Inc., a clinical-stage company developing Nexvax2, a therapeutic vaccine intended to protect against the effects of gluten exposure while maintaining a gluten-free diet in HLA-DQ2.5+ patients with celiac disease, today announced the publication of positive data from two Phase 1 clinical trials of Nexvax2 in celiac disease.

12 May 2017

Research findings identify protein as potential new drug target for HCMV infections

Scientists have demonstrated that a human protein known as valosin containing protein (VCP) is essential for replication of human cytomegalovirus. The findings, published in PLOS Pathogens, identify VCP as a potential new treatment target.

11 May 2017

New organoid ‘fusion’ technique helps observe complex interactions between diverse brain regions

In 2013 researchers led by IMBA scientist Jürgen Knoblich flabbergasted the scientific community. Starting from human stem cells, researchers in his lab managed to grow living three dimensional models of basic units of human brain in a dish.

11 May 2017

Preclinical results of translational research show favorable outcomes in developing Zika virus vaccine

Preclinical results of research by City College of New York scientists and TechnoVax, Inc. in animal models demonstrate favorable outcomes in developing a vaccine against the mosquito-borne Zika virus.

11 May 2017

BGRF scientists help develop AI to expedite drug development for age-related conditions

The Chief Science Officer of the Biogerontology Research Foundation will present new research on artificial intelligence for drug discovery at the NVIDIA Graphics Technology Conference at the San Jose Convention Center, on Wednesday, May 10, 1:00 PM - 1:50 PM alongside two AI scientists from the BGRF and Insilico Medicine, where they will deliver a presentation titled "Applications of Generative Adversarial Networks to Drug Discovery in Oncology and Infectious Diseases".

9 May 2017

UAB spinoff develops drug-resistant immunotherapy to combat solid tumors

The University of Alabama at Birmingham and two partner institutions have received a European patent for their novel approach to fighting cancer, an approach that is led by the UAB spinoff biopharmaceutical company Incysus Ltd.

5 May 2017

Discovery of signaling pathway offers new functional framework for treating schizophrenia

Neuroscientists at Tufts University School of Medicine have discovered a new signaling pathway that directly connects two major receptors in the brain associated with learning and memory – the N-methyl-D-aspartate receptor (NMDAR) and the alpha 7 nicotinic acetylcholine receptor (a7nAChR) – which has significance for current efforts to develop drugs to treat schizophrenia.

4 May 2017

Biotechnology News and Research

Rice University scientists develop and evaluate analogs of potent cancer fighters

Drug rebates reward industry players — and often hurt patients

NCCN ORP funds researchers to evaluate targeted treatment in EGFRm+ non-small cell lung cancer

BGU researchers redesign portion of FDA-approved drug into new molecule to treat ALS

SUNY Downstate researchers find three stressful work characteristics increasing in the U.S.

Researchers study connection between oxytocin and investment in couple relationships

Seventh Wave announces collaboration with Yecuris to study new liver disease therapies

WPI research program aims to understand gender differences in neurobiology

Spanish scientists develop promising gene therapy method to treat Wilson's disease

Researchers identify many dangerous strains of TB pathogens

Breast cancer cells undergo stiffening state prior to becoming malignant, study shows

New approach could help improve management decisions during Ebola outbreak

New research could lead to earlier diagnosis and better management of inflammatory bowel disease

Phase 1 clinical studies reveal safety, tolerability of therapeutic vaccine in celiac disease patients

Research findings identify protein as potential new drug target for HCMV infections

New organoid ‘fusion’ technique helps observe complex interactions between diverse brain regions

Preclinical results of translational research show favorable outcomes in developing Zika virus vaccine

BGRF scientists help develop AI to expedite drug development for age-related conditions

UAB spinoff develops drug-resistant immunotherapy to combat solid tumors

Discovery of signaling pathway offers new functional framework for treating schizophrenia

Industry Focus eBook - Biotechnology (4th edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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