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Researchers grow tumor organoids from blood to tackle breast cancer metastasis

Tumor cells circulating in the blood are the "germ cells" of breast cancer metastases. They are very rare and could not be propagated in the culture dish until now, which made research into therapy resistance difficult.

3 Jan 2025

Stimulant users are caught in fatal ‘fourth wave’ of opioid epidemic

In Pawtucket, Rhode Island, near a storefront advertising "free" cellphones, J.R. sat in an empty back stairwell and showed a reporter how he tries to avoid overdosing when he smokes crack cocaine.

3 Jan 2025

Syringe exchange fears hobble fight against West Virginia HIV outbreak

More than three years have passed since federal health officials arrived in central Appalachia to assess an alarming outbreak of HIV spread mostly between people who inject opioids or methamphetamine.

3 Jan 2025

New nasal swab test for diagnosing asthma subtypes in children

Researchers at the University of Pittsburgh have developed a nasal swab test for kids that diagnoses specific asthma subtype, or endotype.

2 Jan 2025

New immunotherapy shows long-term benefits in preventing squamous cell carcinoma

A new study by investigators from Mass General Brigham uncovers how a novel immunotherapy prevents squamous cell carcinoma, with benefits lasting five years after treatment.

2 Jan 2025

CAR-T cells carry memory of past antigen encounters

Researchers at the University of Colorado Anschutz Medical Campus have discovered that some CAR-T cells engineered to fight cancer and other conditions carry the memory of past encounters with bacteria, viruses and other antigens within them, a finding that may allow scientists to manufacture the cells in more precise and targeted ways.

2 Jan 2025

Insilico Medicine nominates ISM1745 as preclinical candidate for MTAP-deleted cancers

Insilico Medicine ('Insilico'), a clinical-stage generative artificial intelligence (AI)-driven drug discovery and development company, today announced the nomination of ISM1745, a potentially best-in-class MTA cooperative PRMT5 inhibitor with AI-powered novel scaffold, as preclinical candidate (PCC) for the treatment of MTAP-deleted cancers.

2 Jan 2025

Holistic approach needed to combat malaria in sub-Saharan Africa

From fixing open gutters to educating kids about the importance of bed nets, a “whole-of-society” approach is needed to successfully shut down malaria, according to Michael Adekunle Charles, CEO of RBM Partnership to End Malaria—a global grouping of over 500 organisations dedicated to fighting the disease.

2 Jan 2025

Researchers develop tool to measure biological age in individual cell types

A new priority research paper, featured as the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 22, was published on December 29, 2024. The paper is titled "Cell-type specific epigenetic clocks to quantify biological age at cell-type resolution."

2 Jan 2025

MICAL2 enzyme found to promote tumor growth in pancreatic cancer

Pancreatic cancer kills 50,000 people each year, according to the National Cancer Institute, and there are few effective treatment options for the disease.

2 Jan 2025

Histone markers predict human age with accuracy comparable to DNA methylation clocks

Researchers unveil histone-based age predictors, offering a new window into epigenetic aging and its shared patterns across tissues.

2 Jan 2025

Study reveals how fatty liver disease leads to liver cancer

Scientists at University of California San Diego School of Medicine have shed new light on the development of liver cancer, the sixth most frequently diagnosed cancer and fourth leading cause of cancer deaths worldwide.

2 Jan 2025

New research affirms clozapine safety with minimal blood cancer risk

An inter-departmental research team at the LKS Faculty of Medicine of the University of Hong Kong (HKUMed) has conducted the world's first analytic real-world cohort study on the association of clozapine, a highly efficacious antipsychotic drug, with the incidence of blood cancer.

2 Jan 2025

Yale study identifies molecular mechanism behind some lissencephaly disorders

Lissencephaly is a spectrum of rare, genetic disorders in which the brain fails to develop its hallmark folds.

2 Jan 2025

Study uncovers aspartate's surprising role in lung metastases

Researchers from the lab of Prof. Sarah-Maria Fendt (VIB-KU Leuven) and colleagues have uncovered that the availability of the amino acid aspartate is one reason why the lung is a frequent organ of metastasis.

1 Jan 2025

Heated mittens show promise in easing osteoarthritis pain and stiffness

A study assessed heated mittens for hand osteoarthritis, finding significant reductions in pain and stiffness but no improvement in hand function. Further long-term studies are needed to clarify their therapeutic potential.

1 Jan 2025

The science behind phytosome formation and its therapeutic potential

Announcing a new publication for Acta Materia Medica journal. Phytosomes, a novel drug delivery system, have recently attracted substantial attention, because of their exceptional ability to increase the therapeutic efficacy and bioavailability of phytoconstituents.

30 Dec 2024

Laser-textured stents offer promising solution for vascular diseases

The research team led by Dr. Hojeong Jeon and Dr. Hyung-Seop Han of the Biomaterials Research Center at the Korea Institute of Science and Technology (KIST, President Oh Sang-Rok), along with Dr. Indong Jun from KIST Europe, has developed a novel stent surface treatment technology using laser patterning.

26 Dec 2024

Anti-TNF drugs proven to prevent perianal fistulas in Crohn's Disease

Early treatment of pediatric Crohn's disease with anti-tumor necrosis factor medications can substantially reduce the risk of perianal fistulas, a particularly debilitating complication of Crohn's disease.

23 Dec 2024

Twelve factors to protect brain health in the New Year

Improving your brain health in the new year can start with a simple step, talking with your neurologist or primary care physician about 12 factors to protect your brain.

23 Dec 2024