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Cagrilintide and semaglutide together drive record weight loss in global trial

A 68-week phase 3 trial found that coadministered cagrilintide and semaglutide led to significant and clinically meaningful weight loss in adults with obesity but no diabetes. The combination outperformed either drug alone and improved multiple cardiometabolic health markers.

23 Jun 2025

Bispecific antibodies offer new hope for resistant NSCLC patients

As the leading cause of cancer-related death, lung cancer remains a noteworthy hazard to human health. NSCLC is the most prevalent subtype, accounting for nearly 85% of all lung cancer cases.

23 Jun 2025

Low FODMAP diet shown to improve gastrointestinal symptoms in women with endometriosis

A low FODMAP diet developed by Monash University researchers for irritable bowel syndrome (IBS) has been shown to improve gastrointestinal symptoms in women with endometriosis.

23 Jun 2025

Next generation CAR-T cells push the boundaries of lymphoma treatment

CAR-T cells, which are genetically programmed to specifically recognize and kill target cells, have altered the therapeutic landscape of lymphoma.

23 Jun 2025

Melanoma’s excessive mitochondrial dependence becomes a therapeutic vulnerability

Researchers have discovered that the most aggressive melanomas, the deadliest form of skin cancer, overactivate two key processes in mitochondria, the components of cells that provide energy.

23 Jun 2025

Researchers turn a deadly fungus into potent cancer-fighting compound

Penn-led researchers have turned a deadly fungus into a potent cancer-fighting compound. After isolating a new class of molecules from Aspergillus flavus, a toxic crop fungus linked to deaths in the excavations of ancient tombs, the researchers modified the chemicals and tested them against leukemia cells.

23 Jun 2025

Assessment of insulin resistance using TyG index flags rapid cognitive decline in Alzheimer's patients

Insulin resistance detected by routine triglyceride-glucose (TyG) index can flag people with early Alzheimer's who are four times more likely to present rapid cognitive decline, according to new research presented at the European Academy of Neurology (EAN) Congress 2025.

22 Jun 2025

Healthy gut microbiome before chemo could help protect breast cancer patients against cardiotoxicity

New research suggests that a healthy microbiome before chemotherapy could help protect breast cancer patients against heart damage, or cardiotoxicity, as a result of cancer therapy.

21 Jun 2025

Breakthrough study maps hidden protein dynamics in cancer cells

A team of international researchers led by scientists at City of Hope®, one of the largest and most advanced cancer research and treatment organizations in the United States, with its National Medical Center named a Top 5 "Best Hospital" in the nation for cancer care by U.S. News & World Report, provide the most thorough account yet of an elusive target for cancer treatment.

20 Jun 2025

New brain study explains why some pain becomes chronic

A new study reveals that when we experience short-term (acute) pain, the brain has a built-in way to dial down pain signals - like pressing the brakes - to keep them from going into overdrive.

20 Jun 2025

Scientists identify novel combination therapy approach to treat pediatric acute myeloid leukemia

Scientists at St. Jude Children's Research Hospital and Dana-Farber Cancer Institute today report the identification of a novel combination therapy approach to treat pediatric acute myeloid leukemia (AML).

20 Jun 2025

New lab method accelerates diagnosis of genetic disorders of the immune system

A new laboratory method developed by researchers at Columbia University Vagelos College of Physicians and Surgeons may now help physicians more quickly diagnose patients with suspected genetic disorders of the immune system, many who have been trapped in diagnostic limbo for years.

20 Jun 2025

New RSV guideline aims to standardize pediatric care across China

Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory infections (ALRTIs) in children under five and poses a persistent threat to child health worldwide.

20 Jun 2025

Driving breakthroughs for the NF community at the 2025 NF Conference

A new era is unfolding for the NF community. With two FDA-approved treatments now on the market - including the first-ever therapy for adults with NF1 - and cutting-edge advances in AI, drug repositioning, and precision medicine, momentum is building like never before.

20 Jun 2025

VR could be a promising tool to boost rehabilitation for stroke survivors

A Cochrane review has found that virtual reality (VR), when used in addition to standard therapy, can help stroke survivors regain arm movement.

20 Jun 2025

Targeted nanoparticles enable in vivo production of CAR T cells for cancer therapy

Researchers present a new method to safely and preferentially generate CAR T cells directly inside the body using targeted lipid nanoparticles that deliver mRNA directly to T cells.

20 Jun 2025

Exploring the intricate epigenetic regulatory network of lncRNAs in hepatocellular carcinoma

A new review published in Genes & Diseases explores the intricate epigenetic regulatory network of long noncoding RNAs (lncRNAs) in hepatocellular carcinoma (HCC), shedding light on the profound impact of DNA methylation, histone modifications, RNA methylation, and microRNAs on lncRNA transcription.

20 Jun 2025

New nanoparticle system improves drug delivery for cancer treatment

Scientists at Xi'an Jiaotong-Liverpool University (XJTLU) and Nanjing University in China have developed a new drug delivery system that could improve how treatments of cancers and other diseases are delivered.

20 Jun 2025

New clinical trial tests non-invasive method to protect hearts during chemotherapy

A simple intervention, similar to the tension applied to the arm during a blood pressure reading, is being tested in a Phase II clinical trial to see if it can help cancer patients treated with common chemotherapy drugs, called anthracyclines, avoid heart failure.

20 Jun 2025

Targeting IGF2BP1 offers a new approach to cancer therapy

The RNA-binding protein IGF2BP1 has emerged as a key regulator of cancer hallmarks, influencing tumor proliferation, metastasis, immune evasion, and resistance to cell death.

20 Jun 2025

Therapy News and Research

Cagrilintide and semaglutide together drive record weight loss in global trial

Bispecific antibodies offer new hope for resistant NSCLC patients

Low FODMAP diet shown to improve gastrointestinal symptoms in women with endometriosis

Next generation CAR-T cells push the boundaries of lymphoma treatment

Melanoma’s excessive mitochondrial dependence becomes a therapeutic vulnerability

Researchers turn a deadly fungus into potent cancer-fighting compound

Assessment of insulin resistance using TyG index flags rapid cognitive decline in Alzheimer's patients

Healthy gut microbiome before chemo could help protect breast cancer patients against cardiotoxicity

Breakthrough study maps hidden protein dynamics in cancer cells

New brain study explains why some pain becomes chronic

Scientists identify novel combination therapy approach to treat pediatric acute myeloid leukemia

New lab method accelerates diagnosis of genetic disorders of the immune system

New RSV guideline aims to standardize pediatric care across China

Driving breakthroughs for the NF community at the 2025 NF Conference

VR could be a promising tool to boost rehabilitation for stroke survivors

Targeted nanoparticles enable in vivo production of CAR T cells for cancer therapy

Exploring the intricate epigenetic regulatory network of lncRNAs in hepatocellular carcinoma

New nanoparticle system improves drug delivery for cancer treatment

New clinical trial tests non-invasive method to protect hearts during chemotherapy

Targeting IGF2BP1 offers a new approach to cancer therapy

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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