Preclinical News and Research

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New virtual incubator can catalyze early-stage drug discovery and development

Samsara BioCapital, a leading life sciences investment firm, Evotec SE, a global drug discovery alliance and development partnership company (Frankfurt Stock Exchange: EVT, MDAX/TecDAX, ISIN: DE0005664809), and KCK Ltd., a family investment fund, today announced the launch of Autobahn Labs, a novel virtual incubator partnering with top academic and research institutions to catalyze early-stage drug discovery and development.

24 Jun 2020

Health care workers report high levels of distress during the height of COVID-19

During the height of the COVID-19 pandemic in New York City, health care workers on the front lines had high levels of acute stress, anxiety, and depression, a study by researchers at Columbia University Irving Medical Center and NewYork-Presbyterian has found.

23 Jun 2020

St. Jude scientists create O-PDX models for pediatric brain tumor research

Scientists at St. Jude Children's Research Hospital have created orthotopic patient-derived xenograft (O-PDX) models representing a variety of pediatric brain tumor types.

23 Jun 2020

Research reveals new insights into molecular circuitry controlling cancer growth and spread

Research led by Queen Mary University of London has revealed novel insights into the molecular circuitry controlling cancer cell growth and spread.

23 Jun 2020

Jubilant Therapeutics announces preclinical data of dual LSD1 and HDAC6 inhibitor at AACR 2020

Jubilant Therapeutics Inc., a biopharmaceutical company advancing small molecule modulators to address unmet medical needs in oncology and autoimmune diseases, today announced that preclinical data of dual LSD1 and HDAC6 inhibitor JBI-802, will be presented in a poster session at the American Association for Cancer Research 2020 Virtual Annual Meeting II.

23 Jun 2020

Improving cancer therapies by exploiting drug resistance in cancer

News-Medical talks to Professor David Thomas about his recent research identifying the mechanisms behind cancer cells developing resistance to drugs.

23 Jun 2020

Newly discovered Alzheimer's gene may drive earliest brain changes

A newly discovered Alzheimer's gene may drive the first appearance of amyloid plaques in the brain, according to a study led by researchers at Columbia University Irving Medical Center.

22 Jun 2020

UQ superbug drug discoveries will be fast-tracked under international research deal

Antibiotics discovered at The University of Queensland will be fast-tracked under an US$11 million international research deal.

22 Jun 2020

Innovative use of focused ultrasound shows promise against glioblastoma

An innovative use of focused ultrasound being pioneered at the University of Virginia School of Medicine is showing promise against glioblastoma, the deadliest brain tumor, and could prove useful against other difficult-to-treat cancers.

22 Jun 2020

Researchers identify mouse model that mimics HFpEF syndrome in humans

A receptor that plays an essential role in safely clearing chronic unresolved cardiac inflammation may offer new targets for treating an increasing type of heart failure associated with age-related obesity, suggests a preclinical study led by researchers at the University of South Florida Health Heart Institute, Morsani College of Medicine.

22 Jun 2020

Novel vaccine platform against COVID-19 based on engineered human mesenchymal stem cells

In a recent groundbreaking bioRxiv paper, Chinese researchers describe a novel approach towards coronavirus disease (COVID-19) vaccine design based on engineered human mesenchymal stem cells, with favorable and promising antibody response.

22 Jun 2020

Tumor cell–based vaccine may prevent relapse of mantle cell lymphoma

A phase I/II clinical trial by researchers at Stanford University suggests that vaccines prepared from a patient's own tumor cells may prevent the incurable blood cancer mantle cell lymphoma (MCL) from returning after treatment.

22 Jun 2020

Synthetic peptide could be an effective COVID-19 treatment and SARS-CoV-2 vaccine

Ligandal, one of the world’s leading genetic medicine companies, has modeled a synthetic peptide that could be an effective COVID-19 treatment and SARS-CoV-2 vaccine.

22 Jun 2020

Researchers discover new and improved way to treat poor-prognosis blood cancer

Researchers at Children's Cancer Institute have discovered what could prove a new and improved way to treat the poor-prognosis blood cancer, acute myeloid leukemia or AML.

21 Jun 2020

Neighborhood socioeconomic status and household crowding associated with COVID-19

A study of nearly 400 pregnant women in New York City is among the first to show that lower neighborhood socioeconomic status and greater household crowding increase the risk of becoming infected with SARS-CoV-2, the virus that causes COVID-19.

18 Jun 2020

Researchers develop tool to identify proteins associated with drug side effects

A multi-institutional group of researchers led by Harvard Medical School and the Novartis Institutes for BioMedical Research has created an open-source machine learning tool that identifies proteins associated with drug side effects.

18 Jun 2020

Loulou Foundation and IFCR release 'CDKL5 Deficiency Disorder Voice of the Patient Report'

Understanding the patient voice is fundamental for therapy development. Companies need to ensure that what matters most to patients is being assessed, and regulators and payers asks for demonstration of value to support approval and reimbursement.

18 Jun 2020

Researchers call for caution of using CAR-T immunotherapy against AML

Acute myeloid leukemia is a hematological malignancy which incidence increases with age, that is biologically, phenotypically, and genetically very heterogeneous.

17 Jun 2020

Traffic-related air pollution may affect the developing brain

Researchers at the University of California, Davis, have found a link between traffic-related air pollution and an increased risk for changes in brain development relevant to neurodevelopmental disorders.

17 Jun 2020

Exercise has profound protective effect in mouse models of Friedreich's ataxia

A top exercise researcher at the University of Virginia School of Medicine is urging clinical trials of exercise in patients with Friedreich's ataxia after finding that physical activity has a "profound" protective effect in mouse models of the debilitating genetic disease.

16 Jun 2020

Preclinical News and Research

New virtual incubator can catalyze early-stage drug discovery and development

Health care workers report high levels of distress during the height of COVID-19

St. Jude scientists create O-PDX models for pediatric brain tumor research

Research reveals new insights into molecular circuitry controlling cancer growth and spread

Jubilant Therapeutics announces preclinical data of dual LSD1 and HDAC6 inhibitor at AACR 2020

Improving cancer therapies by exploiting drug resistance in cancer

Newly discovered Alzheimer's gene may drive earliest brain changes

UQ superbug drug discoveries will be fast-tracked under international research deal

Innovative use of focused ultrasound shows promise against glioblastoma

Researchers identify mouse model that mimics HFpEF syndrome in humans

Novel vaccine platform against COVID-19 based on engineered human mesenchymal stem cells

Tumor cell–based vaccine may prevent relapse of mantle cell lymphoma

Synthetic peptide could be an effective COVID-19 treatment and SARS-CoV-2 vaccine

Researchers discover new and improved way to treat poor-prognosis blood cancer

Neighborhood socioeconomic status and household crowding associated with COVID-19

Researchers develop tool to identify proteins associated with drug side effects

Loulou Foundation and IFCR release 'CDKL5 Deficiency Disorder Voice of the Patient Report'

Researchers call for caution of using CAR-T immunotherapy against AML

Traffic-related air pollution may affect the developing brain

Exercise has profound protective effect in mouse models of Friedreich's ataxia

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