Preclinical News and Research

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Hesperos’ immune system-on-a-chip emulates immune reactions for tissue damage and acute inflammation

Hesperos Inc., pioneers of the Human-on-a-Chip in vitro system, today announced the publication of a new peer-reviewed publication that describes how the company’s technology can be used to investigate immune responses following treatment with biological therapeutics for multi-organ systemic diseases, including cancer, infectious diseases and inflammatory disorders.

4 Jun 2020

AFFiRiS announces preclinical results of monoclonal antibody mAB C6-17 in Huntington's

AFFiRiS, a clinical-stage biotechnology company developing novel disease-modifying specific active immunotherapies, today announced that detailed preclinical results with its monoclonal antibody mAB C6-17 to treat Huntington's Disease were published in the peer-reviewed journal Neurobiology of Disease.

3 Jun 2020

New project investigating role of B cells in cardiovascular disease receives $6.5 million grant

Christoph Binder, Professor of Atherosclerosis Research at MedUni Vienna, is to coordinate an international research network investigating the role of B cells in cardiovascular disease.

2 Jun 2020

Journal publication supports Synlogic’s first clinical immuno-oncology program, SYNB1891

Synlogic, Inc., a clinical-stage company applying synthetic biology to beneficial microbes to develop novel, living medicines, today announced the publication in Nature Communications of preclinical data supporting its first clinical immuno-oncology program, SYNB1891, which is being evaluated in Phase 1 clinical trial in patients with advanced solid tumors or lymphoma.

2 Jun 2020

ISSCR 2020 Virtual Meeting to deliver comprehensive scientific education program

The International Society for Stem Cell Research has transformed its annual scientific meeting into a virtual experience, bringing the global stem cell community together to share knowledge, collaborate, and network.

2 Jun 2020

Reducing inflammation improves stroke recovery, may extend window for therapy

Reperfusion therapy, the gold standard for stroke treatment, helps restore blood flow after a stroke caused by a clot, preventing loss of brain tissue. However, only about 10% of stroke patients qualify, in part because of reperfusion therapy's narrow treatment window.

1 Jun 2020

Computer modeling reveals necessary vaccine efficacy threshold to prevent SARS-CoV-2 spread

A recent US study showed that in order to prevent or largely extinguish the coronavirus disease 2019 (COVID-19) outbreak without social distancing or any other measures, any vaccine would have to have an efficacy of at least 70%. The research paper is currently available on the medRxiv* preprint server.

1 Jun 2020

Preventing novel coronavirus from entering into a host cell

How might the novel coronavirus be prevented from entering a host cell in an effort to thwart infection? A team of biomedical scientists has made a discovery that points to a solution.

30 May 2020

Clinical trial shows anti-tumor responses in metastatic castration-resistant prostate cancer patients

The preliminary results of a Phase I clinical trial conducted by researchers at the Yale Cancer Center have shown that ARV-110, an androgen receptor PROTAC protein degrader, demonstrates clinical evidence of anti-tumor responses in patients with metastatic castration-resistant prostate cancer (mCRPC) who have failed prior therapy.

29 May 2020

Monoclonal antibody therapy achieves modest reduction in recurrence for patients with HER2-positive DCIS

The addition of the monoclonal antibody therapy Trastuzumab to radiotherapy did not reach the protocol objective of a 36% reduction in the ipsilateral breast tumor recurrence rate for women with HER2-positive ductal carcinoma in situ (DCIS) on the NRG Oncology clinical trial NSABP B-43.

29 May 2020

Cancer drug nilotinib found to be safe and well-tolerated in Alzheimer's disease clinical trial

A Georgetown University Medical Center clinical trial investigating the cancer drug nilotinib in people with Alzheimer's disease finds that it is safe and well-tolerated, and researchers say the drug should be tested in a larger study to further determine its safety and efficacy as a potential disease-modifying strategy.

29 May 2020

NIH funding supports research on first therapeutic drug to regenerate heart tissue

With funding from the National Institutes of Health, University of Arkansas researchers hope to develop the first therapeutic drug that can regenerate heart tissue.

29 May 2020

New drug combinations could help overcome genetic immunotherapy resistance

A new study from researchers at the UCLA Jonsson Comprehensive Cancer Center helps explain how disruptions in genes can lead to the resistance to one of the leading immunotherapies, PD-1 blockade, and how new drug combinations could help overcome resistance to the anti-PD-1 therapy in a mechanistically-based way.

28 May 2020

Transgenic mouse model of HLH may play key role in saving lives during COVID-19

A transgenic mouse developed at Cincinnati Children's to model the deadly childhood immune disease HLH (hemophagocytic lymphohistiocytosis) may play a key role in saving lives during the COVID-19 virus pandemic.

28 May 2020

Researchers develop promising immunotherapy treatment for glioblastoma

Researchers of McMaster University and the University of Toronto have developed a promising immunotherapy treatment for a deadly form of adult brain cancer called glioblastoma.

27 May 2020

Novel immunotherapy targeting myeloid immune cells reduces tumor growth

Checkpoint inhibitors, a type of immunotherapy, that target myeloid immune cells and slow tumor growth were discovered by a team from the Perelman School of Medicine at the University of Pennsylvania and other institutions.

27 May 2020

COVID-19 Rapid Research Fund allows coronavirus research in Ontario and London

Sepsis is a life-threatening condition. It occurs when the body's response to an infection is out of balance, triggering hyperinflammation that can damage multiple organs.

27 May 2020

Antimalarial drug shows promise as potential therapy for aggressive brain cancer

Glioblastoma multiforme is an aggressive form of cancer in the brain that is typically fatal. But new findings by VCU Massey Cancer Center and VCU Institute of Molecular Medicine researchers could help increase the effectiveness of the most common current treatments with the addition of lumefantrine, an FDA-approved drug used to treat malaria.

26 May 2020

Simple molecular 'switch' transforms autoimmunity drugs into powerful anti-cancer treatments

Scientists from the Antibody and Vaccine group at the University of Southampton have discovered a way to transform antibody drugs previously developed to treat autoimmunity into antibodies with powerful anti-cancer activity through a simple molecular "switch".

21 May 2020

Airway and Celonic collaborate to produce AT-100 as therapeutic candidate against COVID-19

Airway Therapeutics, Inc., a biopharmaceutical company developing a new class of biologics to break the cycle of injury and inflammation for patients with respiratory and inflammatory diseases, and Celonic Group, a premium biopharmaceutical CDMO specialized in the development and production of Advance Therapy Medicinal Products (ATMPs) and mammalian cell line-expressed biotherapeutics, today announced a collaboration to produce the novel human recombinant protein AT-100 (rhSP-D) as a therapeutic candidate against COVID-19.

21 May 2020

Preclinical News and Research

Hesperos’ immune system-on-a-chip emulates immune reactions for tissue damage and acute inflammation

AFFiRiS announces preclinical results of monoclonal antibody mAB C6-17 in Huntington's

New project investigating role of B cells in cardiovascular disease receives $6.5 million grant

Journal publication supports Synlogic’s first clinical immuno-oncology program, SYNB1891

ISSCR 2020 Virtual Meeting to deliver comprehensive scientific education program

Reducing inflammation improves stroke recovery, may extend window for therapy

Computer modeling reveals necessary vaccine efficacy threshold to prevent SARS-CoV-2 spread

Preventing novel coronavirus from entering into a host cell

Clinical trial shows anti-tumor responses in metastatic castration-resistant prostate cancer patients

Monoclonal antibody therapy achieves modest reduction in recurrence for patients with HER2-positive DCIS

Cancer drug nilotinib found to be safe and well-tolerated in Alzheimer's disease clinical trial

NIH funding supports research on first therapeutic drug to regenerate heart tissue

New drug combinations could help overcome genetic immunotherapy resistance

Transgenic mouse model of HLH may play key role in saving lives during COVID-19

Researchers develop promising immunotherapy treatment for glioblastoma

Novel immunotherapy targeting myeloid immune cells reduces tumor growth

COVID-19 Rapid Research Fund allows coronavirus research in Ontario and London

Antimalarial drug shows promise as potential therapy for aggressive brain cancer

Simple molecular 'switch' transforms autoimmunity drugs into powerful anti-cancer treatments

Airway and Celonic collaborate to produce AT-100 as therapeutic candidate against COVID-19

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