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Experimental drug protects mice from sudden death due to blood vessel rupture

An experimental drug therapy protects mice from sudden death due to the rupture of a major blood vessel in the abdomen, according to a study from researchers at Washington University School of Medicine in St. Louis.

10 Aug 2022

Using microrobotic platforms for endodontic therapy and diagnostics

With its irregularities and anatomical complexities, the root canal system is one of the most clinically challenging spaces in the oral cavity.

9 Aug 2022

Mount Sinai receives $500,000 SU2C grant to identify therapeutic combinations for KRAS-mutant lung cancers

Mount Sinai is leading a team of lung cancer researchers that has been awarded a three-year, $500,000 grant from Stand Up To Cancer to explore therapeutic approaches to lung tumors with mutations in the KRAS gene, an undertaking that could have a significant impact for a large population of cancer patients who currently lack effective treatment options.

9 Aug 2022

The neutralizing activity of a panel of 482 human monoclonal antibodies against Omicron BA.4 and BA.5

Researchers demonstrated differential utilization of the B cell germlines and SARS-CoV-2 spike protein epitopes by cross-neutralizing antibodies in infected, vaccinated and individuals with hybrid immunity.

9 Aug 2022

Should pregnant women be included clinical trials?

The current study reports some of the scientific, ethical, and legal considerations that will support the inclusion of pregnant women in future research.

8 Aug 2022

Study tests equine polyclonal antibodies against SARS-CoV-2 variants

A recent study published tested equine polyclonal antibodies against SARS-CoV-2.

8 Aug 2022

Research progress on the three-dimensional interaction between virus and host genome

A recent study reviewed the current progress on 3D interactions between host and viral genomes.

8 Aug 2022

Researchers delve deeper into the structure of protein receptor crucial for cardiovascular health

5 Aug 2022

Combination of ultrasound and microbubbles helps medicines pass through the blood-brain barrier

Combining ultrasound and bubbles helps medicines pass through the protective blood-brain barrier and is giving hope for improved treatment of several diseases.

5 Aug 2022

What does the future look like for TB care?

In this interview, we speak to Charles Wells from Gates MRI about their current research into tuberculosis (TB) as well as the recent updated guidelines for TB care.

5 Aug 2022

Heart failure arises from mutations in distinct genes, study finds

Heart failure is a common and devastating disorder for which there is no cure. Many cardiomyopathies - conditions that make it difficult for the heart to pump blood such as dilated cardiomyopathy (DCM) and arrhythmogenic cardiomyopathy (ACM) - can lead to heart failure, but treatments for patients with heart failure do not take these distinct conditions into account.

5 Aug 2022

Extracellular vesicle-based surface protein assay likely to lead to a better way to detect early-stage hepatocellular carcinoma

Primary liver cancer, the third-leading cause of cancer-related death worldwide, takes more than 30,000 lives in the United States each year. The high mortality rates can be attributed in part to the fact that a significant portion of the patients are detected at a late stage, when potentially curative treatments are no longer an option. Unfortunately, today's screening methods are not able to routinely provide accurate, early detection.

5 Aug 2022

Novel fusion protein drug for Alzheimer’s disease circumvents the neurotoxic inflammatory side effects

Although Aduhelm, a monoclonal antibody targeting amyloid beta (Aβ), recently became the first US FDA approved drug for Alzheimer's disease (AD) based on its ability to decrease Aβ plaque burden in AD patients, its effect on cognitive improvement is still controversial.

4 Aug 2022

Mitochondrial DNA mutations are associated with an increased risk of atherosclerosis

Mitochondria are organelles found within most cells, best known for generating the chemical energy required to power cellular functions.

4 Aug 2022

Using native microbes as chassis for transgene delivery in live bacterial therapeutics

Residing within the human gut are trillions of bacteria and other microorganisms that can impact a variety of chronic human ailments, including obesity, type 2 diabetes, atherosclerosis, cancer, non-alcoholic fatty liver disease and inflammatory bowel disease.

4 Aug 2022

Study: Genes involved in coronary heart disease may be nearly the same for everyone

The genes involved in coronary heart disease, the most common form of heart disease, appear to be nearly the same for everyone, according to a VA study.

3 Aug 2022

Turning to Organ-on-a-Chip Studies for the Future of Drug Discovery

In this interview, we speak to Tom Kostrzewski, VP of Science and Technology at CN Bio, about their organ-on-a-chip product and the future of drug discovery.

From CN Bio 3 Aug 2022

Substantial increases in cardiovascular trends contribute to a rising burden on the US health care system

By the year 2060, projected rates of cardiovascular risk factors and disease will increase significantly in the United States, according to a study published today in the Journal of the American College of Cardiology. Substantial increases in cardiovascular trends may contribute to a rising burden on the U.S. health care system and highlight the need for equitable access to prevention education and treatments now to prevent future disease.

3 Aug 2022

Hemopurifier containing Galanthus nivalis resin removes SARS-CoV-2 variants

Scientists hypothesize that the GNA affinity resin would remain effective against SARS-CoV-2 variants.

2 Aug 2022

Gene therapy approach delays disease onset in humanized mouse models of familial ALS

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the progressive loss of motor neurons in the brain and spinal cord responsible for voluntary movements and muscle control.

2 Aug 2022

Therapeutics News and Research

Experimental drug protects mice from sudden death due to blood vessel rupture

Using microrobotic platforms for endodontic therapy and diagnostics

Mount Sinai receives $500,000 SU2C grant to identify therapeutic combinations for KRAS-mutant lung cancers

The neutralizing activity of a panel of 482 human monoclonal antibodies against Omicron BA.4 and BA.5

Should pregnant women be included clinical trials?

Study tests equine polyclonal antibodies against SARS-CoV-2 variants

Research progress on the three-dimensional interaction between virus and host genome

Researchers delve deeper into the structure of protein receptor crucial for cardiovascular health

Combination of ultrasound and microbubbles helps medicines pass through the blood-brain barrier

What does the future look like for TB care?

Heart failure arises from mutations in distinct genes, study finds

Extracellular vesicle-based surface protein assay likely to lead to a better way to detect early-stage hepatocellular carcinoma

Novel fusion protein drug for Alzheimer’s disease circumvents the neurotoxic inflammatory side effects

Mitochondrial DNA mutations are associated with an increased risk of atherosclerosis

Using native microbes as chassis for transgene delivery in live bacterial therapeutics

Study: Genes involved in coronary heart disease may be nearly the same for everyone

Turning to Organ-on-a-Chip Studies for the Future of Drug Discovery

Substantial increases in cardiovascular trends contribute to a rising burden on the US health care system

Hemopurifier containing Galanthus nivalis resin removes SARS-CoV-2 variants

Gene therapy approach delays disease onset in humanized mouse models of familial ALS

Event guide: The Non-Opioid Pain Therapeutics Summit eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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