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Gut microbiota and metabolic changes linked to pregnancy risks in women with PCOS

A new study presented today at the 41st Annual Meeting of the European Society of Human Reproduction and Embryology (ESHRE) reveals that women with polycystic ovary syndrome (PCOS) have distinct gut microbiota and metabolic signatures linked to premature endometrial aging and a higher risk of adverse pregnancy outcomes.

30 Jun 2025

Comprehensive study maps genetic mutations in SLC13A5 linked to epilepsy

Citrate is essential for the metabolism and development of neurons. A membrane transport protein called SLC13A5 plays a central role in this process and has previously been linked to a particularly severe form of epileptic encephalopathy.

30 Jun 2025

Gene therapy shows promise for reducing stroke risk in patients with sickle cell disease

Gene therapy for sickle cell disease may help improve a major contributing factor to stroke risk in patients, reports a new study from St. Jude Children's Research Hospital.

30 Jun 2025

Organ chip technology accurately predicts chemotherapy response in esophageal adenocarcinoma patients

Esophageal adenocarcinoma (EAC), one of two major forms of esophageal cancer, is the sixth most deadly cancer worldwide for which no effective targeted therapy exists.

27 Jun 2025

Early therapy for preschool depression shows long lasting benefits

Depression affects 1%-2% of children younger than 13 in the U.S. and can arise as early as age 3, but a specialized therapeutic intervention can help preschool-aged children find relief from this condition - with benefits lasting at least four years, according to a new study led by researchers at Washington University School of Medicine in St. Louis.

27 Jun 2025

Limiting carcinogen exposure could mitigate liver cancer risk for people with HBV infection

Hepatitis B virus (HBV) infection is known to be associated with the risk of hepatocellular carcinoma (HCC), but how and why they are connected remains unknown.

27 Jun 2025

AI and real-world data can advance patient care in academic health systems

Academic medical centers could transform patient care by adopting principles from learning health systems principles, according to researchers from Weill Cornell Medicine and the University of California, San Diego.

27 Jun 2025

Study maps HER2 mutations in lung cancer patients from Northeastern Brazil

A new research paper was published in Volume 16 of Oncotarget on June 17, 2025, titled "Molecular landscape of HER2-mutated non-small cell lung cancer in Northeastern Brazil: Clinical, histopathological, and genomic insights."

27 Jun 2025

Insilico Medicine begins clinical trial for AI-designed cancer drug ISM3412

Insilico Medicine, a clinical-stage biotechnology company driven by generative artificial intelligence (AI), today announces that the first patient has been dosed in a global multicenter clinical trial (NCT06414460) to evaluate ISM3412, a potentially best-in-class, AI-empowered MAT2A inhibitor with novel structure, in patients with locally advanced and metastatic solid tumors.

27 Jun 2025

Methylene blue emerges as an adjunct in septic shock

Recent evidence suggests methylene blue may help reduce vasopressor needs and ICU stays in septic shock, but current data do not support replacing standard therapies. Further research is needed to clarify its optimal dosing, timing, and patient selection for best outcomes.

26 Jun 2025

Brain injury linked to criminal behavior in new study

A new study led by researchers at the University of Colorado Anschutz Medical Campus, Brigham and Women's Hospital and Harvard Medical School has found that damage to a specific region of the brain may contribute to criminal or violent behavior.

26 Jun 2025

Study finds multimorbidity in nearly half of hospital patients in Malawi and Tanzania

The Multilink Consortium, a NIHR-funded partnership between the Liverpool School of Tropical Medicine, the Malawi-Liverpool-Wellcome Programme, Muhimbili University of Health and Allied Sciences and Kilimanjaro Christian Medical University College, has published the first-of-its-kind research in sub-Saharan Africa to examine the scale and impact of 'multimorbidity' in patients admitted acutely to hospital.

26 Jun 2025

Meningiomas more common in older women than previously known

Tumors of the meninges are more common in older women than previously known. In a study from the University of Gothenburg, 2.7 percent of 70-year-old women had such tumors. The researchers emphasize that such findings should be treated with diligence and careful consideration.

26 Jun 2025