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Flexibility may maximize the potency of peptides used to treat Type 2 diabetes

A little wiggle room might be just what the doctor ordered. New research suggests that the peptides - short chunks of protein - used to treat Type 2 diabetes may be more effective if they're able to flexibly move back and forth between different shapes.

23 Dec 2021

Cryo-EM of Omicron variant reveals antibody evasion by spike-ACE2 complex

Researchers compare the obtained binding affinities to wild-type and Delta spike proteins to determine the impact of Omicron mutations.

23 Dec 2021

New insights into how red meat-rich diet increases cardiovascular disease risk

A Cleveland Clinic-led study has revealed new insights into how a diet rich in red meat increases risk for cardiovascular disease. The findings were published in Nature Microbiology and build on more than a decade of research by lead author Stanley Hazen, MD, PhD.

23 Dec 2021

Researchers receive NIH grants to develop new treatments for neglected tropical diseases

Researchers at Washington University School of Medicine in St. Louis have received two grants from the National Institutes of Health totaling more than $5.5 million to develop new treatments for two types of devastating parasitic infections common in sub-Saharan Africa and Central and South America: river blindness and intestinal worm infections.

22 Dec 2021

Defensosomes can act as decoys to protect against SARS-CoV-2

In a new study, researchers from New York University have been examining the ability of defensosomes to combat SARS-CoV-2 infection.

22 Dec 2021

Polyrotaxane-based biomaterials enhance the connection between epithelial cells

The field of tissue engineering is constantly exploring the possibility of using different properties of various biomaterials to achieve tissue regeneration.

21 Dec 2021

Broad neutralization of SARS-CoV-2 spike protein by an unconventional antibody fragment

A new preprint research paper posted to the bioRxiv* server examines the nature and effects of the spike mutations and identifies a vulnerable point that could help develop broad-spectrum protection against circulating variants.

21 Dec 2021

New oral pill for COVID-19 home treatment

As cases and hospitalizations continue to rise in many countries, new treatments are being sought to arrest the progression of the disease, preventing severe illness and death or disability. One such is the small molecule molnupiravir, the focus of a new research paper.

20 Dec 2021

New study shows how regular exercise protects against fatty liver disease

Exercise not only trains the muscles but can also prevent the development of fatty liver. A new study by the German Center for Diabetes Research, Helmholtz Munich and Tübingen University Hospital shows which molecular adaptations, in particular of the liver mitochondria, can be observed in this process.

20 Dec 2021

Scientists develop first photo-electrochemical aptasensor to detect SARS-CoV-2 virus in saliva

Scientists at the Universidad Carlos III de Madrid (UC3M) have developed the first photo-electrochemical aptasensor that detects the SARS-CoV-2 virus in a saliva sample.

20 Dec 2021

Long-read RNA sequencing identifies important host immune responses during SARS-CoV-2 infection

Researchers conduct a comprehensive in vitro analysis of relatively unexplored host immune responses during SARS-CoV-2 infection.

20 Dec 2021

Impact of acute kidney injury associated gene expression in human kidney cells

A new study attempts to perform a comparative single-cell census of human kidneys employing samples from individuals suffering from acute kidney injury and controls without the condition.

20 Dec 2021

Dreaded microbe can silence multiple types of pain, study suggests

Anthrax has a scary reputation. Widely known to cause serious lung infections in humans and unsightly, albeit painless, skin lesions in livestock and people, the anthrax bacterium has even been used as a weapon of terror.

20 Dec 2021

A new approach for drugs to be more effective against inflammatory bowel disease

Biomedical scientists at the University of California, Riverside, propose a way for drugs to be more effective against inflammatory bowel disease, or IBD, in which the intestine undergoes inflammation.

18 Dec 2021

Identifying protein targets in SARS-CoV-2 via machine learning

A new study provides insight on using an ML-based algorithm to analyze and predict therapeutic targets in emerging pathogens with a range of mutations.

17 Dec 2021

Cedars-Sinai researchers discover growth hormone in the colon that influences aging process

Investigators at Cedars-Sinai have identified growth hormone in the colon that increases as the colon ages—a discovery that can help guide the development of a new anti-aging therapy.

16 Dec 2021

Experimental and computational synergy considered a promising approach in COVID-19 patients

Thanks to the large amount of -omics data becoming increasingly available, sophisticated computational models are developed for new fields such as immunology and the predictions they generate will help identify key molecules in inflammatory processes.

16 Dec 2021

Scientists find better treatment options for patients with advanced colorectal cancer

City of Hope, a world-renowned cancer research and treatment organization, today announced study results of a Phase 2 clinical trial showing monotherapy with sotorasib resulted in anti-tumor activity and a favorable benefit-risk profile among heavily pretreated patients with advanced colorectal cancer. The research was published today in Lancet Oncology.

16 Dec 2021

Researchers develop novel method to supplement cow milk with vegetable protein

Scientists from the Department of Food Science and Technology at The Ohio State University (Columbus, Ohio, USA) have developed a novel method of supplementing cow milk with vegetable protein using readily available current dairy processing equipment.

16 Dec 2021

Evaluation of SARS-CoV-2 Omicron's immune evasion potential

Researchers use VSV vector and Omicron spike protein containing all 32 mutations to create the pseudotyped SARS-CoV-2 Omicron variant (PV-Omicron).

15 Dec 2021

Molecule News and Research

Flexibility may maximize the potency of peptides used to treat Type 2 diabetes

Cryo-EM of Omicron variant reveals antibody evasion by spike-ACE2 complex

New insights into how red meat-rich diet increases cardiovascular disease risk

Researchers receive NIH grants to develop new treatments for neglected tropical diseases

Defensosomes can act as decoys to protect against SARS-CoV-2

Polyrotaxane-based biomaterials enhance the connection between epithelial cells

Broad neutralization of SARS-CoV-2 spike protein by an unconventional antibody fragment

New oral pill for COVID-19 home treatment

New study shows how regular exercise protects against fatty liver disease

Scientists develop first photo-electrochemical aptasensor to detect SARS-CoV-2 virus in saliva

Long-read RNA sequencing identifies important host immune responses during SARS-CoV-2 infection

Impact of acute kidney injury associated gene expression in human kidney cells

Dreaded microbe can silence multiple types of pain, study suggests

A new approach for drugs to be more effective against inflammatory bowel disease

Identifying protein targets in SARS-CoV-2 via machine learning

Cedars-Sinai researchers discover growth hormone in the colon that influences aging process

Experimental and computational synergy considered a promising approach in COVID-19 patients

Scientists find better treatment options for patients with advanced colorectal cancer

Researchers develop novel method to supplement cow milk with vegetable protein

Evaluation of SARS-CoV-2 Omicron's immune evasion potential

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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