Preclinical News and Research

RSS

Nanostimulators can amp up stem cells' regenerative powers for muscle repair

In regenerative medicine, an ideal treatment for patients whose muscles are damaged from lack of oxygen would be to invigorate them with an injection of their own stem cells.

3 May 2020

Lipo-ImmunoTech receives grant to develop novel adoptive cell therapy technology for cancer

Lipo-ImmunoTech, LLC, a startup based in Charleston, South Carolina, recently received a Phase I Small Business Technology Transfer grant of just over $224,000 to continue to develop its novel adoptive cell therapy technology for cancer.

2 May 2020

Combination of schizophrenia drug and radiation shows promise in treating glioblastoma

Researchers at the UCLA Jonsson Comprehensive Cancer Center and colleagues have found that adding a drug once commonly used to treat schizophrenia to traditional radiation therapy helped improve overall survival in mice with glioblastoma, one of the deadliest and most difficult-to-treat brain tumors.

2 May 2020

Using Multiplex Assays to Discover Biomarkers for Parkinson’s Disease

In this interview, Dr. Polinski and Dr. Atabakhsh discuss the importance of developing biomarkers for Parkinson’s and the partnership between MJFF and Abcam.

From Abcam 1 May 2020

Multicolor Immunohistochemistry (IHC): Going Beyond a Single Color

An interview with Dr. Will Howat at SfN 2018, discussing the possibilities and challenges of immunohistochemistry (IHC) beyond a single color!

From Abcam 1 May 2020

Improving Automated NMR Integration Through Deep Learning

In this interview, Data Scientist Federico Paruzzo discusses how Bruker has used deep learning to develop the new command, and how it compares to other approaches available.

From Bruker BioSpin Group 30 Apr 2020

Newly launched clinical trial can help treat COVID-19 patients

Research by University of Iowa virologist Wendy Maury, PhD, has helped facilitate the launch of a new clinical trial in the United Kingdom of a drug that might help treat patients with COVID-19.

30 Apr 2020

Remdesivir shows powerful activity against SARS-CoV-2 in Vitro

Remdesivir is an antiviral first developed by Gilead in 2014 as a treatment for Ebola and Marburg viruses. However, scientists explored its possibilities as a broad-spectrum drug when it proved effective against SARS-CoV and MERS-CoV, coronaviruses which were responsible for earlier outbreaks.

30 Apr 2020

Online searches for unproven therapies for COVID-19

A new observational study by a group of scientists explores the rise in the public's fear-driven interest in unproven therapies for COVID-19, particularly chloroquine and hydroxychloroquine, by tracking the internet searches relating to the purchase of drugs in news reports or publicized by public figures. They conclude: "Stay grounded in evidence and fight misinformation." The research letter and accompanying editorial comment are published in the journal JAMA Internal Medicine.

29 Apr 2020

Antibody produced by llamas shows promise against SARS-CoV-2

The hunt for an effective treatment for COVID-19 has led one team of researchers to find an improbable ally for their work: a llama named Winter.

29 Apr 2020

ACE inhibitors appear to be safe and beneficial for COVID-19, say researchers

Researchers in India have conducted a meta-analysis investigating the effects of using angiotensin-converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARB) on outcomes among patients with COVID-19.

29 Apr 2020

Kurome secures license to develop novel therapies for chemo-resistant cancer

Seed investor CincyTech announced the formation of Kurome Therapeutics ("Kurome"), a preclinical stage company developing novel therapies targeting cancer cells' adaptive resistance mechanisms beginning with hematopoietic, or blood cell, cancers.

29 Apr 2020

Researchers test existing anti-inflammatory drug in COVID-19 patients

An anti-inflammatory drug developed at Scripps Research 25 years ago is now being tested as a way to prevent acute respiratory distress in patients with COVID-19, the pandemic disease caused by the novel coronavirus.

29 Apr 2020

How toxic are chloroquine and hydroxychloroquine to cells?

The spread of the pandemic disease COVID-19 caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has now reached almost every country of the world, with over 3.11 million cases and over 217,000 deaths as of April 29, 2020.

29 Apr 2020

AI system could predict a youth's risk for committing acts of school violence

By leveraging the basics of artificial intelligence technology now used to predict risk for suicide or other mental health issues, researchers developed an AI system that analyzes linguistic patterns to predict a youth's risk for committing acts of school violence.

28 Apr 2020

New nasopharyngeal swabs move into human trials for COVID-19

Researchers at the Wyss Institute at Harvard University, in collaboration with healthcare, research, and industrial partners, have designed a new, fully injection-molded nasopharyngeal swab that can be manufactured quickly and inexpensively at high volume to help address the nationwide and international shortage of swabs for COVID-19 testing and research.

28 Apr 2020

India's Serum Institute gears up to make millions of doses of potential COVID-19 vaccine

The Serum Institute of India plans to start manufacturing Oxford University's COVID-19 vaccine in 3 weeks to get a head start on production, the company announced. This comes even as experts warn that any successful vaccine will take two or more years to come on the market.

28 Apr 2020

The approved dose of ivermectin alone not useful in treating COVID-19

A new paper published on the preprint server medRxiv in April 2020 shows that the use of the already approved drug ivermectin in clinical trials to treat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)s not feasible. This contradicts earlier reports of its ability to suppress the virus in vitro.

27 Apr 2020

Discovery of new type of immune cell in breast ducts

Australian researchers from Walter and Eliza Hall Institute have discovered a new form of immune cells within the ducts of the breast that keeps the breasts healthy. The study was published this week in the journal Nature Cell Biology.

27 Apr 2020

Scientists elucidate novel disease processes involved in pulmonary fibrosis development

Working alongside research groups from Heidelberg, researchers from Charité - Universitätsmedizin Berlin have elucidated the novel disease processes involved in the development of pulmonary fibrosis.

27 Apr 2020