Clinical Trial News and Research

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TBI-associated depression may be a distinct disorder

A new study led by Shan Siddiqi, MD, from Brigham and Women's Hospital, a founding member of the Mass General Brigham healthcare system, suggests that depression after traumatic brain injury (TBI) could be a clinically distinct disorder rather than traditional major depressive disorder, with implications for patient treatment.

5 Jul 2023

Less than half of approved new drugs add substantial therapeutic value over existing treatments

New drugs are often used not only for one disease (first approved indication) but also for other diseases (supplemental indications).

5 Jul 2023

Medical cannabis laws have no effect on opioid prescriptions, study finds

State laws allowing medical cannabis use did not reduce prescriptions for opioids or other therapies for chronic, non-cancer pain, according to a policy analysis by Weill Cornell Medicine investigators.

5 Jul 2023

Clinical trial of three-month TB treatment regimen closed due to high rate of unfavorable outcomes

The first clinical trial of a three-month tuberculosis (TB) treatment regimen is closing enrollment because of a high rate of unfavorable outcomes with the investigational course of treatment.

5 Jul 2023

Critical questions raised for evaluation of anti-amyloid immunotherapies in Alzheimer's treatment

Anti-amyloid immunotherapies for Alzheimer's disease require thorough evaluation of their efficacy, safety, and cost-effectiveness. Key questions regarding statistical analyses, treatment effects, and disease course modification guide evidence-based consideration of these drugs.

4 Jul 2023

PSI-developed drug could increase survival chances for metastatic prostate cancer patients

Researchers at PSI have developed a new drug that could increase the survival chances of patients with metastatic prostate cancer.

4 Jul 2023

SIRT1: Unlocking the secrets to better vascular health through resveratrol and energy restriction

Research investigates the effects of SIRT1 activation through resveratrol supplementation and energy restriction on vascular function in adults. The study reveals that both interventions increase circulating SIRT1, reduce sympathetic activity, and have positive impacts on vascular reactivity, indicating potential benefits for vascular health.

3 Jul 2023

Vitamin D supplements may reduce risk of heart attacks in people over 60

Vitamin D supplements may reduce the risk of major cardiovascular events such as heart attacks among people aged over 60, finds a clinical trial published by The BMJ today.

3 Jul 2023

Menopausal hormone therapy associated with increased rate of dementia and Alzheimer's disease

Use of menopausal hormone therapy is associated with an increased rate of dementia and Alzheimer's disease, suggests a large Danish study published by The BMJ today.

3 Jul 2023

New COVID-19 mRNA vaccine is safe and highly immunogenic as a heterologous booster: Study

The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in more than 600 million confirmed cases and 6.5 million deaths worldwide.

3 Jul 2023

Towards Zika preparedness: immunogenicity insights from vaccine research

Study assesses the safety and immunogenicity of an inactivated Zika virus vaccine candidate.

30 Jun 2023

Tirzepatide triumphs in significant weight reduction for people with type 2 diabetes

Researchers performed a double-blinded, placebo-controlled phase III randomized clinical trial (RCT).

29 Jun 2023

The Lancet study unveils exciting findings on retatrutide as a novel treatment for type 2 diabetes

Researchers performed a phase II randomized clinical trial (RCT).

29 Jun 2023

Study reveals oral Semaglutide 50 mg as promising treatment for obesity in adults: the Lancet report

Researchers performed a phase III randomized clinical trial (RCT).

29 Jun 2023

Vitamin D supplements may reduce risk of heart attacks in older adults

Vitamin D supplements may reduce the risk of major cardiovascular events such as heart attacks among people aged over 60, finds a clinical trial published by The BMJ today.

28 Jun 2023

Trial shows no benefit of prescribing an opioid for people with acute back or neck pain

Opioid pain-relieving medicines are not more effective than a placebo in relieving acute back and neck pain and may even cause harm, according to a world-first trial led by the University of Sydney.

28 Jun 2023

Use of menopausal hormone therapy associated with increased rate of dementia and Alzheimer's

Use of menopausal hormone therapy is associated with an increased rate of dementia and Alzheimer's disease, suggests a large Danish study published by The BMJ today.

28 Jun 2023

New drug effective as a treatment against ulcerative colitis, clinical trial shows

A new drug, investigated by Amsterdam UMC together with colleagues around the world, is effective as a treatment against ulcerative colitis.

28 Jun 2023

Simple blood test combined with risk model improves lung cancer mortality prediction

A blood-based test developed by researchers at The University of Texas MD Anderson Cancer Center can efficiently predict an individual's risk of dying from lung cancer when combined with a personalized risk model.

28 Jun 2023

Alcohol use raises the risks of 61 diseases in Chinese men

Alcohol consumption increases the risks of over 60 diseases in Chinese men, including many diseases not previously linked to alcohol, according to a new study by researchers from Oxford Population Health, Peking University, and the Chinese Academy of Medical Sciences. The study is published today in Nature Medicine.

28 Jun 2023

Clinical Trial News and Research

TBI-associated depression may be a distinct disorder

Less than half of approved new drugs add substantial therapeutic value over existing treatments

Medical cannabis laws have no effect on opioid prescriptions, study finds

Clinical trial of three-month TB treatment regimen closed due to high rate of unfavorable outcomes

Critical questions raised for evaluation of anti-amyloid immunotherapies in Alzheimer's treatment

PSI-developed drug could increase survival chances for metastatic prostate cancer patients

SIRT1: Unlocking the secrets to better vascular health through resveratrol and energy restriction

Vitamin D supplements may reduce risk of heart attacks in people over 60

Menopausal hormone therapy associated with increased rate of dementia and Alzheimer's disease

New COVID-19 mRNA vaccine is safe and highly immunogenic as a heterologous booster: Study

Towards Zika preparedness: immunogenicity insights from vaccine research

Tirzepatide triumphs in significant weight reduction for people with type 2 diabetes

The Lancet study unveils exciting findings on retatrutide as a novel treatment for type 2 diabetes

Study reveals oral Semaglutide 50 mg as promising treatment for obesity in adults: the Lancet report

Vitamin D supplements may reduce risk of heart attacks in older adults

Trial shows no benefit of prescribing an opioid for people with acute back or neck pain

Use of menopausal hormone therapy associated with increased rate of dementia and Alzheimer's

New drug effective as a treatment against ulcerative colitis, clinical trial shows

Simple blood test combined with risk model improves lung cancer mortality prediction

Alcohol use raises the risks of 61 diseases in Chinese men

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