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Custom-tailored anti-cancer drugs

Cancer remains a deadly threat despite the best efforts of science. New hopes were raised a few years ago with the discovery that the uncontrolled growth of cancer cells could be thwarted by blocking the action of proteasomes. Biochemists at the Technische Universitaet Muenchen (TUM) have illuminated a reaction pathway that does just that, in collaboration with researchers from Nereus Pharmaceuticals, based in San Diego, California. In the current issue of the Journal of Medicinal Chemistry, they report insights that could potentially lead to the development of custom-tailored anti-cancer drugs.

19 Aug 2009

Global Fund awards Tanzania $111 million grant for ITNs

Tanzania will receive an $111 million grant from the Global Fund to Fight AIDS, Tuberculosis and Malaria for insecticide-treated nets (ITNs) to be used in the country's fight against malaria, Ray Chambers, U.N. special envoy for malaria, said at a meeting in Dar es Salaam, Tanzania, on Monday, Reuters reports.

19 Aug 2009

Scientists create new method to detect genetic causes of complex diseases

Computational biologists at Carnegie Mellon University have developed an analytical technique to detect the multiple genetic variations that contribute to complex disease syndromes such as diabetes, asthma and cancer, which are characterized by multiple clinical and molecular traits.

14 Aug 2009

AHRA and Toshiba partner on putting patients first program

Patient safety and quality care continue to be important issues for hospitals and imaging centers. To help these facilities start new or build upon existing programs, AHRA: The Association for Medical Imaging Management announces the second year of its Putting Patients First grant program.

10 Aug 2009

Protein unfolding key to understanding blood clot mechanics

Fibrin, the chief ingredient of blood clots, is a remarkably versatile polymer. On one hand, it forms a network of fibers -- a blood clot -- that stems the loss of blood at an injury site while remaining pliable and flexible. On the other hand, fibrin provides a scaffold for thrombi, clots that block blood vessels and cause tissue damage, leading to myocardial infarction, ischemic stroke, and other cardiovascular diseases. How does fibrin manage to be so strong and yet so extensible under the stresses of healing and blood flow?

6 Aug 2009

Colon cancer may yield to cellular sugar starvation

Scientists at the Johns Hopkins Kimmel Cancer Center have discovered how two cancer-promoting genes enhance a tumor's capacity to grow and survive under conditions where normal cells die.

6 Aug 2009

Research looks at enzyme that causes genetic diseases

Researchers from CIC bioGUNE's Structural Biology Unit and Columbia University (New York) have conducted a joint research project, published in the prestigious scientific journal Structure, to gain in-depth knowledge of the structure of pyruvate carboxylase when it is in solution (in the "natural" state).

5 Aug 2009

Compact gamma camera for prostate cancer imaging

The U.S. Department of Energy's Brookhaven National Laboratory and Hybridyne Imaging Technologies, Inc., of Toronto, Canada, have won a 2009 R&D 100 Award for developing a compact gamma camera for high-resolution imaging of prostate cancer.

23 Jul 2009

Early inflammatory signs of osteoarthritis

Researchers at The University of Nottingham are hoping to find out if inflammation of the knee could be an early sign of osteoarthritis - a condition which leads to pain, stiffness, swelling and disability.

23 Jul 2009

Hepatitis C infection: Treatment options equally effective, likelihood of success known early on

Results of a long-awaited study of 3,070 American adults at Johns Hopkins and 118 other U.S. medical centers show that treatment with either of the two standard antiviral drug therapies is safe and offers the best way for people infected with hepatitis C to prevent liver scarring, organ failure and death.

22 Jul 2009

Hydrogen sulphide investigated for role in pregnancy

Scientists at the University of Leicester are investigating how the stuff of stink bombs and flatulence could play a critical role in the human reproductive system.

20 Jul 2009

Special pathway makes bacteria vulnerable - new target for tailored antibiotics

More and more strains of bacteria are developing resistance to previously life-saving antibiotics. Researchers at TUM, the Technische Universitaet Muenchen, have shed light on a metabolic step that appears in many aggressive microorganisms -- such as tuberculosis and malaria pathogens -- and that may provide a promising target for a new class of antibiotics. The researchers present their results in the chemistry journal Angewandte Chemie.

14 Jul 2009

Obesity associated with increased risk of rapid cartilage loss

Obesity, among other factors, is strongly associated with an increased risk of rapid cartilage loss, according to a study published in the August issue of Radiology.

14 Jul 2009

Thiarabine shows promise for rheumatoid arthritis

Access Pharmaceuticals, Inc. announced today new preclinical data demonstrating that thiarabine shows remarkable efficacy in the prevention and treatment of rheumatoid arthritis (RA).

7 Jul 2009

FDA approves Hologic's permanent contraception system

Hologic, Inc.today announced the U.S. Food and Drug Administration (FDA) has approved the Company's premarket approval (PMA) application for the Adiana permanent contraception system.

From Hologic, Inc. 7 Jul 2009

Breast milk ingredient protects babies' intestines

Scientists at Queen Mary, University of London have discovered that an ingredient in human breast milk protects and repairs the delicate intestines of newborn babies.

30 Jun 2009

Computer-guided nanoparticle therapy destroys tumors

Gold nanoshells are among the most promising new nanoscale therapeutics being developed to kill tumors, acting as antennas that turn light energy into heat that cooks cancer to death. Now, a multi-institutional research team has shown that polymer-coated gold nanorods one-up their spherical counterparts, with a single dose completely destroying all tumors in a nonhuman animal model of human cancer.

28 Jun 2009

Colorado rural co-ops provide example for health care system proposal

Rural utility co-ops in Colorado could provide an example of how a co-op would work nationally for health care, The Denver Post reports.

25 Jun 2009

NewsHour features two health experts on President Obama's global health initiative

On the NewsHour Insider Forum, Ray Suarez interviews global health experts Michele Moloney-Kitts, assistant U.S. global AIDS coordinator, and Christine Lubinski, head of the Center for Global Health Policy and Advocacy about President Obama's $63 billion global health initiative.

24 Jun 2009

Telemedicine expands reach of care for Parkinson’s patients

A unique and innovative telemedicine project is providing distant nursing home patients with Parkinson's disease access to neurologists at the University of Rochester Medical Center (URMC).A pilot study of the project - the results of which were released this month at the International Congress of Parkinson's Disease and Movement Disorders in Paris - demonstrates that the system can improve the quality of life and motor function of patients.

17 Jun 2009