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New combination treatment offers hope for older patients with mantle cell lymphoma

The phase 2 trial PrE0405 met its primary endpoint, achieving a complete response (CR) rate of 85% in 33 patients over the age of 60 with mantle cell lymphoma (MCL) who received bendamustine and rituximab, a standard chemo-immunotherapy treatment, along with venetoclax, which is investigational in this setting.

11 Dec 2023

Lymphatic fluid from surgical drains could inform more precise treatments for head and neck cancer

Lymphatic fluid from surgical drains, which is usually tossed in the trash, is a treasure in the hands of University of Pittsburgh and Washington University School of Medicine in St. Louis researchers who found that this liquid could inform more precise treatments for patients with head and neck cancer caused by human papillomavirus (HPV).

11 Dec 2023

Study reveals genetic roots of hodgkin lymphoma, offering hope for new treatments

A Stanford Medicine-led, international study of hundreds of samples from patients with Hodgkin lymphoma has shown that levels of tumor DNA circulating in their blood can identify who is responding well to treatment and others who are likely to experience a disease recurrence - potentially letting some patients who are predicted to have favorable outcomes forgo lengthy treatment.

11 Dec 2023

New drug combo shows promise in targeting RAS-mutant multiple myeloma

The combination of a drug and a protein fragment prevents the growth of blood cancer cells, a new study in mice shows.

11 Dec 2023

New organoid model could revolutionize neuroendocrine tumor research

The Organoid Group (Hubrecht Institute) and the Rare Cancers Genomics Team (IARC/WHO) found a way to grow samples of different types of neuroendocrine tumors (NETs) in the lab.

11 Dec 2023

Breakthrough in pancreatic cancer treatment: Inhibiting specific enzymes slows tumor progression

Study demonstrates that inhibiting stromal class I histone deacetylases (HDACs) can effectively slow down pancreatic cancer progression, shedding light on a new therapeutic approach targeting the tumor microenvironment.

10 Dec 2023

Study explores the intricate gut-brain-liver connection and its impact on health

Study reviews the gut-brain-liver axis, revealing the complex interplay between these organs in health and disease and the implications for therapeutic interventions, focusing on how gut microbiota affects liver and brain health.

10 Dec 2023

Low-risk DCIS patients may safely skip radiotherapy after surgery, study finds

Patients with low-risk ductal carcinoma in situ (DCIS) who skipped adjuvant radiotherapy after breast-conserving surgery had comparable five-year outcomes to those with high-risk DCIS who received adjuvant radiotherapy, according to results from the E4112 clinical trial presented at the San Antonio Breast Cancer Symposium, held December 5-9, 2023.

8 Dec 2023

Exploring the role of liquid biopsies in early-stage prostate cancer

A new research perspective was published in Oncoscience (Volume 10) on November 30, 2023, entitled, "Evolving insights in blood-based liquid biopsies for prostate cancer interrogation."

8 Dec 2023

Researchers discover next-gen lipid nanoparticles for muscle-focused mRNA delivery

A team of researchers based at the University of Toronto's (U of T) Leslie Dan Faculty of Pharmacy has discovered a novel ionizable lipid nanoparticle that enables muscle-focused mRNA delivery while minimizing off-target delivery to other tissues.

8 Dec 2023

Scientists decode key factor in T cell lymphoma growth, paving way for new treatments

A team from the Technical University of Munich (TUM) has decoded the factor that makes T cell lymphomas grow comparatively rapidly: A missing "emergency shut-off switch" results in the lymphomas processing particularly large amounts of sugar and triggers other processes as well.

8 Dec 2023

Fused pancreatic cancer organoid system captures tumor heterogeneity and drug resistance

Pancreatic ductal adenocarcinoma (PDAC), that arises from pancreatic epithelial cells, is the most common form of pancreatic cancer, with a very high mortality rate.

7 Dec 2023

Researchers discover how bexmarilimab activates immune cells against tumors

Researchers at the University of Turku, Finland, have uncovered how the new bexmarilimab therapy alters the function of immune cells so that they can infiltrate the tumor in cancer patients who do not respond to any other current therapies.

7 Dec 2023

The association between viral infections and glioma risk

The causal relationship between viral infection and glioma.

7 Dec 2023

Blocking an allergy pathway unleashes antitumor immunity in mouse models of non-small cell lung cancer

Researchers at the Icahn School of Medicine at Mount Sinai have identified an allergy pathway that, when blocked, unleashes antitumor immunity in mouse models of non-small cell lung cancer (NSCLC).

6 Dec 2023

HDAC inhibitors may offer new strategy for reversing fibrotic wall around pancreatic tumors

Pancreatic cancer is one of the deadliest cancers - only about one in eight patients survives five years after diagnosis.

6 Dec 2023

Revolutionary self-folding nanoscale MRI agent sharpens cancer imaging

Study introduces a novel self-folding nanoscale contrast agent for MRI, enhancing tumor visualization with lower gadolinium loads and reduced risk of adverse effects.

5 Dec 2023

Study uses game theory to show low tumor heterogeneity leads to higher aggression

A study by the University of the Basque Country (UPV/EHU) uses game theory to establish that tumors with less cellular heterogeneity are more aggressive.

5 Dec 2023

Osteopontin-c: A key player in mitochondrial biogenesis and cancer metastasis

A new research paper was published in Oncotarget's Volume 14 on December 1, 2023, entitled, "Osteopontin induces mitochondrial biogenesis in deadherent cancer cells."

5 Dec 2023

Novel mRNA vaccine GLB-COV2-043 shows high efficacy against COVID-19 variants in early trials

The safety, efficacy, and immunogenicity of a mRNA-based vaccine.

5 Dec 2023

Tumor News and Research

New combination treatment offers hope for older patients with mantle cell lymphoma

Lymphatic fluid from surgical drains could inform more precise treatments for head and neck cancer

Study reveals genetic roots of hodgkin lymphoma, offering hope for new treatments

New drug combo shows promise in targeting RAS-mutant multiple myeloma

New organoid model could revolutionize neuroendocrine tumor research

Breakthrough in pancreatic cancer treatment: Inhibiting specific enzymes slows tumor progression

Study explores the intricate gut-brain-liver connection and its impact on health

Low-risk DCIS patients may safely skip radiotherapy after surgery, study finds

Exploring the role of liquid biopsies in early-stage prostate cancer

Researchers discover next-gen lipid nanoparticles for muscle-focused mRNA delivery

Scientists decode key factor in T cell lymphoma growth, paving way for new treatments

Fused pancreatic cancer organoid system captures tumor heterogeneity and drug resistance

Researchers discover how bexmarilimab activates immune cells against tumors

The association between viral infections and glioma risk

Blocking an allergy pathway unleashes antitumor immunity in mouse models of non-small cell lung cancer

HDAC inhibitors may offer new strategy for reversing fibrotic wall around pancreatic tumors

Revolutionary self-folding nanoscale MRI agent sharpens cancer imaging

Study uses game theory to show low tumor heterogeneity leads to higher aggression

Osteopontin-c: A key player in mitochondrial biogenesis and cancer metastasis

Novel mRNA vaccine GLB-COV2-043 shows high efficacy against COVID-19 variants in early trials

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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