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Rare STAT6 gene variant provides protection against severe asthma

Scientists at deCODE genetics, a subsidiary of Amgen, and collaborators have published a study in Journal of Allergy and Clinical Immunology reporting a rare missense variant in STAT6 that protects against asthma.

15 Nov 2024

EASI algorithm set to transform forensic drug identification processes

Relief is coming for crime scene investigators and toxicologists who have struggled to accurately and swiftly identify drugs that have been seized by law enforcement and may be relied on as evidence at trial, thanks to a research partnership between West Virginia University and the U.S. Drug Enforcement Administration.

15 Nov 2024

Psychedelics may offer anxiety relief through specific brain circuits

New research suggests that it could be possible to separate treatment from hallucinations when developing new drugs based on psychedelics.

15 Nov 2024

Breakthrough in protein engineering may lead to more effective cancer therapies

Researchers from Auburn University, partnering with the University of Basel in Switzerland, have discovered a new way to make a cancer-targeting protein complex more stable, opening doors to better cancer treatments.

15 Nov 2024

New discovery reveals NMDAR's critical function in maintaining brain stability

Researchers at Tel Aviv University have made a fundamental discovery: the NMDA receptor (NMDAR) - long studied primarily for its role in learning and memory - also plays a crucial role in stabilizing brain activity.

15 Nov 2024

Customizable biological sensors activate cancer immunotherapy only in tumor environments

Most cancer treatments – from chemotherapies to engineered immune cells – have a host of side effects, in large part because they affect healthy cells in the body at the same time as targeting tumor cells.

15 Nov 2024

Study reveals high-resolution structure of blood pressure-regulating receptor

Weill Cornell Medicine researchers have determined the full-length structure of a blood pressure-regulating hormone receptor for the first time, uncovering how it functions, which may enable better drug targeting of the receptor for diseases like hypertension and heart failure.

15 Nov 2024

Researchers discover mechanism affecting splicing process in retinal cells

Genes contain the essential building instructions for life, guiding cells on which amino acids to assemble in what sequence to produce specific proteins. The human genome codes for about 20,000 such instructions.

15 Nov 2024

Argonne receives $21.7 million to advance cancer and vaccine discoveries

The U.S. Department of Energy's (DOE) Argonne National Laboratory will use its world-leading capabilities in artificial intelligence (AI) and high performance computing to research novel ways to fight cancer and transform vaccine discovery.

15 Nov 2024

AI-powered tool predicts gene activity in cancer cells from biopsy images

To determine the type and severity of a cancer, pathologists typically analyze thin slices of a tumor biopsy under a microscope.

14 Nov 2024

Prenatal cannabis exposure linked to increased risk of opioid addiction later in life

With the increased legalization of recreational cannabis, as many as 1 in 5 pregnant women in the U.S. are now using the drug to help with morning sickness, lower back pain or anxiety.

14 Nov 2024

New drug strategy reverses resistance to immunotherapy in pancreatic cancer

A new drug strategy that regulates the tumor immune microenvironment may transform a tumor that resists immunotherapy into a susceptible one, according to a study by researchers from the Johns Hopkins Kimmel Cancer Center and Oregon Health & Science University.

14 Nov 2024

Leveraging genetic variations for more effective cancer therapies

By exploiting the genetic variation in cancer cells, an already approved cancer drug demonstrated enhanced effects against cancer cells in specific patient groups.

14 Nov 2024

Scientists map cancer mutations in EGFR gene, revealing drug resistance paths

Researchers used base and prime editing to uncover new EGFR gene mutations that affect cancer progression and drug resistance, paving the way for personalized treatment strategies.

14 Nov 2024

Scientists fear what’s next for public health if RFK Jr. is allowed to ‘go wild’

Many scientists at the federal health agencies await the second Donald Trump administration with dread as well as uncertainty over how the president-elect will reconcile starkly different philosophies among the leaders of his team.

14 Nov 2024

After Congress ended extra cash aid for families, communities tackle child poverty alone

If you bring a baby into the Hurley Children's Center clinic in downtown Flint, Michigan, Mona Hanna will find you.

14 Nov 2024

FasL inhibitor speeds recovery and reduces mortality in severe COVID-19 patients

A new clinical study shows that an inhibitor of Fas ligand (FasL), also called CD95 ligand (CD95L), led to a faster recovery of COVID-19 patients and reduced mortality.

14 Nov 2024

Study shows how microbial load affects gut health and disease

In sickness or in health, the billions of microorganisms that inhabit our guts are our constant companions throughout life. In the past few decades, scientists have shown how the nature of this 'microbiome' can provide valuable clues to human diseases and their treatment.

14 Nov 2024

Study finds weakness in drug-resistant tuberculosis pathogens

A University of Otago-led study has found highly vulnerable weakness in drug-resistant Mycobacterium tuberculosis, offering a new way to kill them.

13 Nov 2024

Rutgers study sheds light on how bedaquiline fights drug-resistant tuberculosis

Rutgers Health research has uncovered why a relatively new antibiotic for tuberculosis (TB) works against multidrug-resistant strains, potentially inspiring improved treatments and drug development strategies.

13 Nov 2024