Therapeutics News and Research

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Listeria-based booster vaccine strategy offers improved protection against recurrent colorectal cancer

Colorectal, pancreatic, esophageal and stomach cancers - some of the deadliest kinds of cancer - have high recurrence rates where the cancer comes back even after successful surgery or radiation treatment.

23 Jun 2022

Preclinical study unlocks the promise of CAR T-cell therapy for treatment of solid tumors

Scientists at St. Jude Children's Research Hospital identified a molecular mechanism that in a preclinical study unlocked the promise of CAR T–cell therapy for treatment of solid tumors.

22 Jun 2022

New pain medications with high abuse potential more likely to be successfully developed

Despite the prevalence and societal costs of pain in the United States, investment in pain medication development is low, due in part to poor understanding of the probability of successful development of such medications

21 Jun 2022

Insufficient drug exposure most likely to cause COVID-19 rebound

Paxlovid is the leading oral medication for preventing severe cases of COVID-19 in high-risk individuals.

21 Jun 2022

Research may pave the way for a future test to diagnose ALS

Amyotrophic lateral sclerosis (ALS) is a progressive disease of the nervous system. It affects nerve cells in the brain and spinal cord called motor neurons.

21 Jun 2022

How specific comorbidities impact severity of COVID-19

Researchers identify the association between severe COVID-19 and specific comorbidities.

20 Jun 2022

Evaluating post-acute sequelae of COVID-19 using cardiopulmonary exercise testing

Researchers demonstrated reduced exercise capacity due to persistent cardiopulmonary symptoms among COVID-19 survivors hospitalized for acute infection and those having long COVID.

20 Jun 2022

Conceptual framework to examine the patterns of copy number alterations in human cancer

A new study published in Nature presented a conceptual framework to examine the patterns of copy number alterations in human cancer.

17 Jun 2022

Demonstrating varying pathogenicity and tropism of SARS-CoV-2 variants in a feline model

In a recent study posted to the bioRxiv* pre-print server, researchers at Cornell University College of Veterinary Medicine and the University of Illinois Urbana-Champaign compared the infection dynamics, pathogenicity, and tissue tropism of multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants in adult cats.

17 Jun 2022

UB program secures $12.8 million to improve the quality of global HIV research

The National Institutes of Health (NIH) has awarded $12.8 million to the University at Buffalo School of Pharmacy and Pharmaceutical Sciences to lead a clinical pharmacology quality assurance program for NIH-funded laboratories and research networks across the globe conducting HIV and infectious disease research.

16 Jun 2022

Cryo-electron microscopy structure of SARS-CoV-2 membrane protein

In a recent study posted to the bioRxiv* pre-print server, researchers illustrated the cryo-electron microscopic (cryo-EM) structure of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) membrane (M) protein in lipid nanodiscs to 3.5 angstroms (Å) resolution.

16 Jun 2022

Multiomics identifies genomic risk factors for COVID-19

In a recent Cell Systems study, researchers utilized the RefMap machine learning algorithm to correlate known genomic variations for severe COVID-19 obtained from large-scale genome-wide association studies (GWAS) with single-cell multiome profiling of human lungs.

16 Jun 2022

LifeArc and UK DRI launch new partnership to accelerate development of new treatments for dementia

LifeArc and the UK Dementia Research Institute (UK DRI) have today launched a new partnership to accelerate development of new diagnostic tests, treatments, and devices from scientific research discoveries to benefit people with dementia, which around 900,000 people in the UK are living with.

15 Jun 2022

Researchers create first bona fide mouse model of Merkel cell carcinoma

A team of researchers at the University of Michigan Rogel Cancer Center were the first to generate a bona fide mouse model of a Merkel cell carcinoma, a rare and potentially aggressive form of skin cancer.

15 Jun 2022

Drug combinations may help to slow the progression of diabetic kidney disease

A mouse study led by Washington University School of Medicine in St. Louis suggests that combining SGLT2 inhibitors — a newer class of diabetes medications that lowers blood sugar — with older diabetes drugs may help to slow the progression of diabetic kidney disease.

15 Jun 2022

Blood levels of ceramides could help predict type 2 diabetes remission after gastric bypass surgery

A newly developed test could help doctors more accurately predict whether individuals who undergo gastric bypass surgery will experience a remission of type 2 diabetes within two years of the procedure, according to University of Utah Health scientists.

15 Jun 2022

Androgen receptor signaling affects response to targeted therapy in people with melanoma

Androgen receptor (AR) signaling affects response to BRAF/MEK inhibitor therapy in both males and females with melanoma, researchers from The University of Texas MD Anderson Cancer Center showed in a study published today in Nature.

15 Jun 2022

Novel nanoparticle therapeutics shows promise to fight solid tumors

Researchers from Wake Forest University School of Medicine have discovered a possible new approach to treating solid tumors through the creation of a novel nanoparticle. Solid tumors are found in cancers such as breast, head and neck, and colon cancer.

14 Jun 2022

Spirea raises £2.4M ($3M) to develop antibody drug conjugates in cancer

Funding will enable the development of Spirea’s pipeline of antibody drug conjugate therapeutics for the treatment of solid tumours.

From Spirea 14 Jun 2022

The role of IgA antibodies against COVID-19

Researchers observed that immunoglobulin A (IgA) responses against SARS-CoV-2 are modest and wane much sooner than IgG responses.

14 Jun 2022

Therapeutics News and Research

Listeria-based booster vaccine strategy offers improved protection against recurrent colorectal cancer

Preclinical study unlocks the promise of CAR T-cell therapy for treatment of solid tumors

New pain medications with high abuse potential more likely to be successfully developed

Insufficient drug exposure most likely to cause COVID-19 rebound

Research may pave the way for a future test to diagnose ALS

How specific comorbidities impact severity of COVID-19

Evaluating post-acute sequelae of COVID-19 using cardiopulmonary exercise testing

Conceptual framework to examine the patterns of copy number alterations in human cancer

Demonstrating varying pathogenicity and tropism of SARS-CoV-2 variants in a feline model

UB program secures $12.8 million to improve the quality of global HIV research

Cryo-electron microscopy structure of SARS-CoV-2 membrane protein

Multiomics identifies genomic risk factors for COVID-19

LifeArc and UK DRI launch new partnership to accelerate development of new treatments for dementia

Researchers create first bona fide mouse model of Merkel cell carcinoma

Drug combinations may help to slow the progression of diabetic kidney disease

Blood levels of ceramides could help predict type 2 diabetes remission after gastric bypass surgery

Androgen receptor signaling affects response to targeted therapy in people with melanoma

Novel nanoparticle therapeutics shows promise to fight solid tumors

Spirea raises £2.4M ($3M) to develop antibody drug conjugates in cancer

The role of IgA antibodies against COVID-19

Industry Focus eBook - Microbiome (1st edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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