Dysplasia News and Research

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Dysplasia is a term used in pathology to refer to an abnormality in maturation of cells within a tissue. This generally consists of an expansion of immature cells, with a corresponding decrease in the number and location of mature cells.

Inovio's SynCon DNA vaccine effective at inducing CD8+ T cell responses specific to CMV

Inovio Pharmaceuticals, Inc. announced today that testing of multiple synthetic vaccine constructs for cytomegalovirus (CMV) induced robust T cells in mice, demonstrating the potential for a SynCon DNA vaccine to treat this virus that causes infant death and congenital abnormalities, is associated with cerebral palsy and brain tumors, and is the most common viral infection in organ transplant recipients. CMV is also associated with numerous inflammatory diseases and cancers, and is implicated in hypertension, a major risk factor for cardiovascular diseases.

26 Nov 2012

New research helps improve quality of life-saving blood transfusions for preterm babies

Results of new research from the University of Adelaide are a promising step forward in helping to improve the quality of life-saving blood transfusions for preterm babies, by reducing the likelihood of adverse inflammatory responses to the blood.

26 Nov 2012

Colorectal cancer patient siblings ‘deserve screening’

Colorectal cancer screening should be offered to the siblings of affected patients, recommends a team of researchers from Hong Kong.

22 Nov 2012

Enrollment complete in Exact Sciences DeeP-C screening trial for colorectal cancer

Exact Sciences Corp. today announced it has completed patient enrollment in its DeeP-C pivotal trial for colorectal cancer screening. The study enrolled more than 12,700 patients at sites in the United States and Canada.

15 Nov 2012

Study shows how NCH guidelines improve quality of life for extremely premature infants

For the last decade, prematurity has been the leading cause of infant mortality in the United States. As a result of prematurity many infants enter this world too early with a small chance of survival. In order to help treat these extremely premature infants, physicians at Nationwide Children's Hospital developed a set of guidelines tailored to meet the needs of these tiny infants, some born up to four months early.

1 Nov 2012

Advaxis updates preliminary data from ADXS-HPV Phase 2 trial on cervical cancer

Advaxis, Inc., a leader in developing the next generation of immunotherapies for cancer and infectious diseases, updated preliminary data from an ongoing randomized 110 patient Phase 2 trial of ADXS-HPV being conducted in India in women with recurrent/refractory cervical cancer who have failed previous cytotoxic therapy.

1 Nov 2012

EMR before radiofrequency ablation safe and effective for patients with nodular Barrett's esophagus

A new study shows that endoscopic mucosal resection (EMR) before radiofrequency ablation (RFA) is a safe and effective treatment option for patients with nodular Barrett's esophagus (BE) and advanced neoplasia.

17 Oct 2012

Cigarette smoke adversely affects the developing human airway

Research presented at the ANESTHESIOLOGY 2012 annual meeting revealed cigarette smoke adversely affects the developing human airway, especially in prematurity. Fetuses and premature babies exposed to cigarette smoke are at greater risk for developing childhood respiratory diseases, such as asthma.

16 Oct 2012

Therapeutic HPV16 and HPV18 vaccine ‘may eliminate infection’

A candidate vaccine against human papillomavirus serotypes 16 and 18 appears to induce robust immune responses to antigens, potentially leading to the elimination of virus-infected cells and regression of dysplasia, say US investigators.

15 Oct 2012

Tissue test detects oral cancer risk

A molecular diagnostic scoring system based on patients’ FOXM1-associated gene messenger RNA expression levels is able to quantitatively diagnose and stratify oral carcinoma and its aggressiveness, show UK and Norwegian study results.

11 Oct 2012

Transfused blood age does not impact outcomes in premature babies

Using fresh red blood cells for premature babies who need blood transfusions does not improve outcomes over use of standard blood bank donations, show study findings published in JAMA.

9 Oct 2012

Minimally invasive esophagectomy viable alternative to open surgery

Patients undergoing surgery for esophageal cancer may benefit from minimally invasive techniques as much as they do from open surgery, say researchers.

11 Sep 2012

Researchers identify genetic variations linked with onset of Barrett's oesophagus

Genetic variations that are linked with the onset of Barrett's oesophagus (BE), a pre-cancerous condition of the lower end of the gullet, have been identified for the first time. The discovery of variations in regions on two chromosomes makes it possible to develop screening tests for people at high risk of developing the disease.

10 Sep 2012

Quest Diagnostics announces availability of TERC test for cervical cancer

Quest Diagnostics, the world's leading provider of diagnostic testing, information and services, today announced the availability of a new laboratory test that identifies molecular changes to cervical cells that increase the likelihood a woman may develop cervical cancer.

From Quest Diagnostics 31 Aug 2012

Heartburn and cancer: an interview with Mindy Mintz Mordecai

What most of us think of as heartburn is a symptom of Reflux Disease or GERD (Gastroesophageal Reflux Disease). It’s that burning discomfort an individual experiences when stomach acids and other fluids come back up into their esophagus.

14 Aug 2012

Advaxis reports continued positive patient survival pattern in ADXS-HPV Phase 2 cervical cancer trial

Advaxis, Inc.,, a leader in developing the next generation of immunotherapies for cancer and infectious diseases, presented updated preliminary data from an ongoing randomized Phase 2 trial of ADXS-HPV being conducted in India in women with recurrent/refractory cervical cancer who have failed previous cytotoxic therapy.

30 Jul 2012

Endoscopy, better tissue sampling required to improve care for patients with oesophageal cancer

The world's largest review of all the evidence on the best way of managing and treating common pre-cancerous and cancerous conditions of the oesophagus (gullet) has found that good endoscopy equipment, more endoscopic surgery, and more tissue sampling are required to improve care for patients.

24 Jul 2012

Researchers begin to uncover important clues about SCAD

Spontaneous coronary artery dissection (SCAD), a tear of the layers of the artery wall that can block normal blood flow into and around the heart, is a relatively rare and poorly understood condition. It often strikes young, otherwise healthy people -- mostly women -- and can lead to significant heart damage, even sudden death.

17 Jul 2012

More selective colon cancer screening urged

Updated guidance from a US task force stresses the need for targeted, high-quality follow-up screening in patients who have undergone colonoscopy or polyp removal, in an effort to cut down on unnecessary repeat procedures

11 Jul 2012

Inovio commences SynCon vaccine phase I study in H1N1 influenza

Inovio Pharmaceuticals, Inc. announced today that the first patients have been treated in a clinical trial evaluating immune responses in elderly adults immunized with Inovio's H1N1 SynCon universal influenza vaccine.

10 Jul 2012