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Topical cream activates immune response to suppress skin cancer growth

A topical cream activated the skin's immune defenses and suppressed tumor growth in two preclinical models of cutaneous squamous cell carcinoma (cSCC), one of the most common cancers in the world, according to a study published today in the Journal of Clinical Investigation.

12 Mar 2026

Disrupting protein production in tumors triggers potent immune responses

A new study led by Pierre Close's team (GIGA, Laboratory of Cancer Signaling, and WELRI Investigator) reveals how subtly disrupting the way tumors produce their proteins can trigger a potent antitumor immune response.

11 Mar 2026

Single receptor PAR1 controls opposing responses in blood vessels

Researchers at the University of California San Diego have uncovered how a single protein triggers two opposite responses in blood vessels - one inflammatory and one protective.

10 Mar 2026

EVA1A regulates fatty acid transporter CD36 in fatty liver disease

Metabolic Dysfunction-Associated Steatotic Liver Disease（MASLD） is characterized by excessive accumulation of lipids in hepatocytes and is closely associated with the rapid rise in insulin resistance, obesity, and diabetes prevalence, making it one of the most common chronic liver diseases worldwide.

9 Mar 2026

Enzyme helps maintain retinal progenitor cells during eye development

The retina is a thin layer of neural tissue at the back of the eye that detects light and converts it into signals, sent to the brain.

9 Mar 2026

Largest genetic study classifies 14 psychiatric disorders into five major groups

Although mental disorders have multifactorial causes, genetics can explain some of them, yet this field remains largely unexplored in terms of guiding diagnoses and treatments.

9 Mar 2026

Ketone body can strengthen the fitness and antitumor activity of CAR T cells

A naturally occurring byproduct of liver metabolism–the ketone body, β-hydroxybutyrate (BHB)–can strengthen the fitness and antitumor activity of CAR T cells.

6 Mar 2026

Scientists identify ANKIB1 as key regulator of innate immune signaling

Innate immune sensors – known as pattern recognition receptors (PRRs) – detect specific molecular components of bacterial or viral intruders.

6 Mar 2026

Research reveals nuclear metabolic fingerprint in human cells

More than two hundred metabolic enzymes, many of which are normally tasked with producing energy in the mitochondria, are also found sitting directly on top of human DNA, according to a study published today in Nature Communications.

6 Mar 2026

BCAT2 enzyme identified as a target for diabetic foot recovery

Diabetic macrovascular complications are the main cause of death and disability in diabetes patients, of which vascular calcification is one of the key pathological mechanisms. Calcification in atherosclerotic plaque can cause stiffness and decreased compliance of the vascular wall, and induce atherosclerotic plaque rupture, which increases the risk of acute cardiovascular events.

6 Mar 2026

Copper metabolism identified as a new therapeutic target for inflammatory osteolysis

Inflammatory osteolysis is a condition involving progressive bone tissue destruction and is observed in many well-known skeletal disorders, including rheumatoid arthritis, osteoporosis, and chronic apical periodontitis.

5 Mar 2026

Mathematical model identifies how estrogen protects women from high blood pressure

High blood pressure, or hypertension, affects more than one billion people worldwide and is a leading cause of heart disease and stroke.

4 Mar 2026

Study links high-fat diet to faster breast cancer progression

If you're diagnosed with breast cancer, what should you eat to ensure the best prognosis?

3 Mar 2026

Research suggests new therapeutic targets for broad-spectrum antiviral drugs

Coronaviruses not only use the machinery of the human cells they infect: they modify it to achieve optimal conditions to produce viral proteins and thus spread more quickly. This is the main conclusion of a study by Pompeu Fabra University published in Nature Communications.

3 Mar 2026

New method isolates true transcription factor targets in tuberculosis bacteria

Inside every cell, thousands of molecular signals collide, overlap, and compensate, obscuring the true drivers of gene expression.

2 Mar 2026

Targeted fluorescent probes for high-contrast cancer detection

Cancer is a universal issue that affects uncountably many people around the world. Many will turn to surgery in the hope that a surgeon will be able to completely remove a tumor, leaving healthy tissues unaffected. Various tools and techniques have been developed over the years to improve the way these surgeries are performed, and visual imaging methods such as glowing dyes have proven to be very useful.

2 Mar 2026

Common cardio drugs proven safe in myeloma patients

Commonly prescribed cardiovascular medications—such as statins, diuretics, and blood pressure drugs—appear to have little or no negative impact on survival among people living with multiple myeloma, according to new international research.

1 Mar 2026

How zinc deficiency could worsen heart inflammation and what that means for patients

This review examines how zinc regulates inflammatory and redox signaling pathways involved in myocarditis and pericarditis, highlighting mechanisms such as NF-κB inhibition and the redox zinc switch. The authors conclude that maintaining optimal zinc status may support cardiovascular resilience, while emphasizing that clinical translation requires further targeted trials.

1 Mar 2026

Scientists discover how muscle stem cells "flip a switch" to rebuild damaged muscle

Scientists at the University of California, Irvine's School of Pharmacy & Pharmaceutical Sciences have discovered how muscle stem cells "flip a switch" to rebuild damaged muscle – a finding that could help address muscle loss linked to aging, injury and widely used weight-loss medications.

27 Feb 2026

Identifying the core catalyst for muscle energy production

Researchers have investigated the role of a certain enzyme in regulating energy in muscle and exercise performance for decades, but a new study by Virginia Tech scientists has identified more precisely than ever how this mechanism works.

26 Feb 2026