Tamoxifen News and Research

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Tamoxifen is a drug used to treat certain types of breast cancer in women and men. It is also used to prevent breast cancer in women who have had ductal carcinoma in situ (abnormal cells in the ducts of the breast) and in women who are at a high risk of developing breast cancer. Tamoxifen is also being studied in the treatment of other types of cancer. It blocks the effects of the hormone estrogen in the breast. Tamoxifen is a type of antiestrogen. Also called tamoxifen citrate.

Androgen receptor an additional hormonal target in many breast cancers

Many breast cancers depend on hormones including estrogen or progesterone for their survival and proliferation. Eight years of lab work at the University of Colorado Cancer Center and elsewhere suggest that the androgen (AR) receptor is an additional hormonal target in many breast cancers. Block AR+ breast cancer's ability to access androgen and you block the cancer's ability to survive.

5 Jun 2012

Study shows valuable role of Mammostrat in assessing ER+ postmenopausal breast cancer patients

GE Healthcare today announced results from the Tamoxifen and Exemestane Adjuvant Multinational (TEAM) Trial at the 2012 Annual Meeting of the American Society of Clinical Oncology.

4 Jun 2012

New clinical trial to evaluate HSP90 inhibitor plus hormonal therapy for breast cancer

Pushed to the brink of survival, the hyper-driven cells of a cancerous tumor tap into an ancient system that has helped organisms cope with internal stresses and environmental challenges since life began. As an integral part of this system, heat shock protein 90 (HSP90) has been shown to help malignant cells accommodate the genetic changes and profound disturbances in normal biology that occur in cancers.

23 May 2012

Project aims to find new diagnostic tools, drugs for triple negative breast cancer

Some types of breast cancer can be successfully treated with drugs such as tamoxifen, but treatment for a type of breast cancer more common in young and black women is still limited to radiation and general chemotherapy. Called triple negative breast cancer, this type of cancer is the focus of a 20-month, $8.6-million research project that aims to find new diagnostic tools and options for drugs.

17 May 2012

NanoString commences second clinical study of PAM50-based breast cancer assay

NanoString Technologies, Inc., a privately held provider of life science tools for translational research and developer of molecular diagnostics, today announced the initiation of the second clinical validation study of its PAM50-based breast cancer assay.

From NanoString Technologies 17 May 2012

Combination of vaccine and letrozole effectively improves survival from breast cancer

A vaccine that targets cancer cells in combination with the drug letrozole, a standard hormonal therapy against breast cancer, significantly increased survival when tested in mice, a team of UC Davis investigators has found.

16 May 2012

Latest statistics: Cancer deaths in 50-59 year olds have dropped to 14,000

The number of people in their 50s dying prematurely from cancer in the UK has fallen below 14,000 for the first time in 40 years according to new Cancer Research UK figures published today.

15 May 2012

Analysis stresses importance of multidisciplinary approach to cancer in the elderly

New research showing that almost half of 13,000 patients with head and neck cancers had other health-related problems at the same time is one of the presentations in a special session at the 31st conference of the European Society for Radiotherapy and Oncology (ESTRO 31) today.

14 May 2012

MicroRNAs in breast cancer play a role in development of resistance to tamoxifen

Many breast cancer patients are treated with a drug called tamoxifen. The substance blocks the effect of estrogen and thus suppresses the growth signals of this hormone in cancer cells. When resistance to the drug develops, tumor cells change their growth program: They change their behavior and shape, become more mobile and also adopt the ability to invade surrounding tissue. Scientists working with PD (Associate Professor) Dr. Stefan Wiemann of the German Cancer Research Center (DKFZ) have now also observed these changes in tamoxifen resistant breast cancer cells.

5 May 2012

New light on many biological differences between individual breast cancers

New findings presented at Europe's leading breast cancer translational research conference this year shed new light on the many biological differences between individual breast cancers.

4 May 2012

New analysis may help identify breast cancer patients who will benefit from immune suppressant

A new analysis may help doctors identify breast cancer patients who will benefit from treatment with the immune suppressant drug everolimus, say French researchers at the 4th IMPAKT Breast Cancer Conference in Brussels, Belgium.

4 May 2012

Breast cancer treatment and classification revolutionized in landmark study

Breast cancer treatment could be revolutionized with patients offered more accurate diagnoses and better-targeted treatments after a study in which scientists genetically charted the disease. The research found that rather than being a single disease, breast cancer can be classified into 10 distinct types. It also identified several new genes that determine the aggressiveness of the cancer.

19 Apr 2012

Web-based decision guide reduces uncertainty about breast cancer prevention options

When women at high risk of breast cancer viewed a customized web-based decision guide about prevention options, they were more likely to make a choice about prevention and to feel comfortable with their choice, a new study finds.

16 Apr 2012

Powerful link between circadian rhythms and metabolism

The discovery of a major gear in the biological clock that tells the body when to sleep and metabolize food may lead to new drugs to treat sleep problems and metabolic disorders, including diabetes.

7 Apr 2012

NutraGene introduces first ever commercial type 2 diabetes genetic test

With the launch of the country's first ever commercial genetic test for type 2 diabetes, Indians will now have access to clinically relevant and cost effective genetic risk assessment services. NutraGene, a Delhi based genomics company that launched the tests believes that its type 2 diabetes genetic test will provide physicians an effective tool in assessing the risk of diabetes in the Indian population and will help in implementing personalized prevention and management strategies.

3 Apr 2012

STAT-1 and PLSCR-1 proteins could play a crucial role in breast cancer

At the time of diagnosis, the majority of breast cancers are categorized as estrogen-receptor positive, or hormone sensitive, which means their cancerous cells may need estrogen to grow. Patients with this type of cancer often respond favorably to treatments called aromatase inhibitors, like tamoxifen, which cause cell death by preventing estrogen from reaching the cancerous cells.

2 Apr 2012

Obese or overweight women may have increased risk of breast cancer recurrence

Women who are overweight or obese when they are diagnosed with breast cancer are at higher risk of cancer recurrence or related death than are leaner women, according to a new study to be presented to the 8th European Breast Cancer Conference.

26 Mar 2012

Combination of everolimus and exemestane reduces spread of cancer in the bone

Results from a phase III clinical trial evaluating a new treatment for breast cancer in post-menopausal women show that the combination of two cancer drugs, everolimus and exemestane, significantly improves bone strength and reduces the chances of cancer spreading (metastasising) in the bone.

23 Mar 2012

Higher risk of breast cancer recurrence in overweight, obese women

23 Mar 2012

Only few OB-GYNs routinely inquire about patients' sexual issues

How often does your doctor ask about your sexual life? Unfortunately, the answer may be: not often enough. Leaving the subject off the check-up checklist could mean missing an important link to overall wellness.

23 Mar 2012

Tamoxifen News and Research

Further Reading

Androgen receptor an additional hormonal target in many breast cancers

Study shows valuable role of Mammostrat in assessing ER+ postmenopausal breast cancer patients

New clinical trial to evaluate HSP90 inhibitor plus hormonal therapy for breast cancer

Project aims to find new diagnostic tools, drugs for triple negative breast cancer

NanoString commences second clinical study of PAM50-based breast cancer assay

Combination of vaccine and letrozole effectively improves survival from breast cancer

Latest statistics: Cancer deaths in 50-59 year olds have dropped to 14,000

Analysis stresses importance of multidisciplinary approach to cancer in the elderly

MicroRNAs in breast cancer play a role in development of resistance to tamoxifen

New light on many biological differences between individual breast cancers

New analysis may help identify breast cancer patients who will benefit from immune suppressant

Breast cancer treatment and classification revolutionized in landmark study

Web-based decision guide reduces uncertainty about breast cancer prevention options

Powerful link between circadian rhythms and metabolism

NutraGene introduces first ever commercial type 2 diabetes genetic test

STAT-1 and PLSCR-1 proteins could play a crucial role in breast cancer

Obese or overweight women may have increased risk of breast cancer recurrence

Combination of everolimus and exemestane reduces spread of cancer in the bone

Higher risk of breast cancer recurrence in overweight, obese women

Only few OB-GYNs routinely inquire about patients' sexual issues

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