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UMD awarded grant to develop an integrated hypertension management program for older adults

To address the significant health burden of hypertension (characterized by consistently high blood pressure), the University of Maryland (UMD) was recently awarded a grant from the United States Department of Agriculture National Institute of Food and Agriculture (USDA-NIFA) to develop, test, and deliver an integrated hypertension management program for older adults.

22 Jul 2021

Largest genetic study identifies new drug targets to treat type 1 diabetes

Scientists have completed the largest and most diverse genetic study of type 1 diabetes ever undertaken, identifying new drug targets to treat a condition that affects 1.3 million American adults.

22 Jul 2021

Study examines the host and viral factors that drive SARS-CoV-2 evolution

In a new paper recently uploaded to the preprint server bioRxiv*, two clinical isolates of SARS-CoV-2 are monitored by whole genome sequencing as they are passaged through several generations of Vero cells or human-derived primary nasal epithelial cells (PNEC), allowing direct observation of the occurrence of virus enhancing mutations and the way in which host cell factors shape virus evolution.

21 Jul 2021

UTHSC announces an increase in research grant and contract awards for FY21

The University of Tennessee Health Science Center's Office of Research announced that annual research grant and contract awards for FY21, which ended June 30, total more than $121 million, a 20.6% increase from last year.

20 Jul 2021

Study examines clinical outcomes in vaccinated individuals hospitalized with SARS-CoV-2 Delta variant

A new study has been published on the medRxiv* preprint server that has evaluated the clinical outcomes of the COVID-19 patients hospitalized in AIG hospitals, Hyderabad, India, between April 24, 2021, and May 31, 2021.

20 Jul 2021

Study proves effectiveness of Artemisia annua against SARS-CoV-2 in vitro

A multinational research group has been the first to show the excellent activity of artemisinin-based treatment against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in human cell lines – including a specific type of lung cells. Their findings were recently published in the journal Scientific Reports.

19 Jul 2021

Researchers use appendiceal cancer organoids to study personalized immunotherapy response

Wake Forest researchers and clinicians are using patient-specific tumor 'organoid' models as a preclinical companion platform to better evaluate immunotherapy treatment for appendiceal cancer, one of the rarest cancers affecting only 1 in 100,000 people.

19 Jul 2021

Oral prodrug delivers carbon monoxide to protect against acute kidney injury

An oral prodrug developed by a team of scientists led by Binghe Wang, Regents' Professor of Chemistry at Georgia State University, delivers carbon monoxide to protect against acute kidney injury, according to a new paper published in Chemical Science.

19 Jul 2021

SARS-CoV-2 B.1.617 mutations L452 and E484Q do not work together to evade antibodies

A short report recently published in the Journal of Infectious Diseases demonstrates how spike mutations L452R and E484Q found in the variant B.1.617.1 of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) each confer modestly diminished sensitivity to Pfizer-BioNTech (BNT162b2) mRNA vaccine-elicited antibodies – with combined mutations having a similar impact as either one of them alone.

19 Jul 2021

New concise recommendations for managing osteoporosis in patients with chronic kidney disease

Patients with advanced chronic kidney disease (CKD) typically suffer from impaired bone quality and quantity, with a non-vertebral fracture risk which is 4-to 6-fold higher than the fracture risk of matched controls. However, despite their high risk of fragility fractures, the vast majority of patients with chronic CKD stages 4 to 5D, are not receiving osteoporosis therapy.

15 Jul 2021

Antihypertension drug may benefit patients with neurofibromatosis type 2

New research led by investigators at Massachusetts General Hospital and Massachusetts Eye and Ear indicates that the blood pressure drug losartan may benefit patients with neurofibromatosis type 2 (NF2), a hereditary condition associated with vestibular schwannomas, or noncancerous tumors along the nerves in the brain that are involved with hearing and balance.

15 Jul 2021

Component derived from turmeric essential oil exhibits neuroprotective effects

Researchers from Kumamoto University, Japan have found that a component derived from turmeric essential oil, aromatic turmerone (ar-turmerone), and its derivatives act directly on dopaminergic nerves to create a neuroprotective effect on tissue cultures of a Parkinson's disease model.

14 Jul 2021

Antidepressants may lower risk of death, complications in people with diabetes and depression

People with diabetes and depression who take antidepressants may have a lower risk of death and of serious diabetes complications, according to a new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism.

14 Jul 2021

Research identifies key role of CXCL9 cytokine in age-related chronic inflammation

An inflammatory-aging clock called developed by Stanford University School of Medicine and the Buck Institute for Research on Aging can predict how strong your immune system will be in 10 years, when you'll become frail or whether you may develop cardiovascular diseases a few years down the road.

14 Jul 2021

Study: Benefit-to-harm balance of statins for primary prevention of heart disease is favorable

Statins are associated with a small increased risk of side effects in patients without a history of heart disease, but these effects are mild compared with the potential benefits of treatment in preventing major cardiovascular events, say researchers in The BMJ today.

14 Jul 2021

Israeli study of breakthrough infections following full BNT-Pfizer vaccination, 40% immunocompromised

Severe forms of coronavirus disease (COVID-19) linked to high mortality rates might arise in a minority of fully-vaccinated individuals with many co-occurring medical conditions, finds a recent study by Israeli researchers published in the journal Clinical Microbiology and Infection.

13 Jul 2021

COVID-19 vaccine allocation based on health, socioeconomic factors may help minimize deaths

COVID-19 vaccination strategies in the United States are informed by individual characteristics such as age and occupation.

13 Jul 2021

USF receives $69.9 Million NIH funding to continue study on type 1 diabetes

The National Institutes of Health has awarded the University of South Florida total expected funds of $69.9 million over the next four years to continue the follow-up of study participants in The Environmental Determinants of Diabetes in The Young (TEDDY) consortium.

13 Jul 2021

“React and inject”: synthetic peptide-modified nanodiamonds as emergency pan-coronavirus vaccines

A recent study published in the MDPI journal, Pathogens, describes a coronavirus peptide vaccine antigen in the form of nanodiamond-based formulations, that demonstrated a robust and long-lasting immune response. The nanodiamonds proved to be a powerful and versatile platform for antigen conjugation. This could make it a safe and effective strategy for the production of off-the-shelf vaccines against multiple coronaviruses.

13 Jul 2021

Prioritization of COVID-19 vaccination is improved by including health and socioeconomic factors

Allocating COVID-19 vaccines has been determined primarily by age group, but a new study shows that other factors including health risks are also important.

13 Jul 2021

Kidney News and Research

UMD awarded grant to develop an integrated hypertension management program for older adults

Largest genetic study identifies new drug targets to treat type 1 diabetes

Study examines the host and viral factors that drive SARS-CoV-2 evolution

UTHSC announces an increase in research grant and contract awards for FY21

Study examines clinical outcomes in vaccinated individuals hospitalized with SARS-CoV-2 Delta variant

Study proves effectiveness of Artemisia annua against SARS-CoV-2 in vitro

Researchers use appendiceal cancer organoids to study personalized immunotherapy response

Oral prodrug delivers carbon monoxide to protect against acute kidney injury

SARS-CoV-2 B.1.617 mutations L452 and E484Q do not work together to evade antibodies

New concise recommendations for managing osteoporosis in patients with chronic kidney disease

Antihypertension drug may benefit patients with neurofibromatosis type 2

Component derived from turmeric essential oil exhibits neuroprotective effects

Antidepressants may lower risk of death, complications in people with diabetes and depression

Research identifies key role of CXCL9 cytokine in age-related chronic inflammation

Study: Benefit-to-harm balance of statins for primary prevention of heart disease is favorable

Israeli study of breakthrough infections following full BNT-Pfizer vaccination, 40% immunocompromised

COVID-19 vaccine allocation based on health, socioeconomic factors may help minimize deaths

USF receives $69.9 Million NIH funding to continue study on type 1 diabetes

“React and inject”: synthetic peptide-modified nanodiamonds as emergency pan-coronavirus vaccines

Prioritization of COVID-19 vaccination is improved by including health and socioeconomic factors

Free guide - Everything about renal proximal tubule cells eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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