Pathology News and Research

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Pathology is the study and diagnosis of disease through examination of organs, tissues, bodily fluids, and whole bodies (autopsies). The term also encompasses the related scientific study of disease processes, called General pathology. Medical pathology is divided in two main branches, Anatomical pathology and Clinical pathology. Veterinary pathology is concerned with animal disease whereas Phytopathology is the study of plant diseases.

Production of six monoclonal antibodies against SARS-CoV-2 spike protein

Youjia Guo et al. in a recent bioRxiv preprint paper demonstrate the robust performance of mouse anti-SARS-CoV-2 spike monoclonal antibodies in immunoassays, including western blotting, ELISA, immunofluorescence, and immunoprecipitation and also neutralizing activity in vitro against SARS-CoV-2 infection.

5 Oct 2020

High levels of folic acid during pregnancy could harm brain development of embryos

A UC Davis MIND Institute study of pregnant mice found that high amounts of folic acid during pregnancy harmed the brain development of embryos. Researchers say the findings indicate that more investigation is needed about the best recommended dosage for pregnant women.

5 Oct 2020

Researchers receive $3.2 million to use AI for improving heart transplant outcomes

A team of researchers in the Perelman School of Medicine at the University of Pennsylvania, Case Western Reserve University, Cleveland Clinic, and Cedars-Sinai Medical Center, were recently awarded a $3.2 million grant from the National Institutes of Health to enhance research for improving heart transplant outcomes for patients.

5 Oct 2020

Scientists discover small molecules that may reduce cellular stress

For many, getting older can unfortunately mean an increased risk of illness from cardiovascular disease to cancer.

5 Oct 2020

New, rare genetic form of dementia discovered

A new, rare genetic form of dementia has been discovered by a team of Penn Medicine researchers. This discovery also sheds light on a new pathway that leads to protein build up in the brain -- which causes this newly discovered disease, as well as related neurodegenerative diseases like Alzheimer's Disease -- that could be targeted for new therapies.

1 Oct 2020

$9.1 million NCI grant renewal will support researchers studying retrovirus cancer models

The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute and The Ohio State University College of Veterinary Medicine have been awarded a five-year, $9.1 million grant Program Project Grant renewal from the National Cancer Institute.

1 Oct 2020

Social isolation worsens the effects of Alzheimer's disease, study shows

A study in mice conducted by the UAB shows that social isolation worsens the effects of Alzheimer's disease, with hyperactivity levels reaching up to twice as much as in the pathology itself.

1 Oct 2020

Researchers receive NCI grant to study role of collagens in breast cancer

An MUSC Hollings Cancer Center researcher received a $3 million grant from the National Cancer Institute to study how patterns of collagens can serve as biomarkers of breast cancer risk and potentially reveal clues to what might be driving health disparities.

1 Oct 2020

Researchers identify a promising method to treat multiple sclerosis

Seema Tiwari-Woodruff, a professor of biomedical sciences in the School of Medicine at the University of California, Riverside, and her colleagues have received a grant of $373,000 from the National Multiple Sclerosis Society for a project in which her lab will select the five best candidate compounds to speed up nerve impulses, a promising new avenue to treat multiple sclerosis.

1 Oct 2020

Patients with invasive lobular carcinoma could benefit from additional adjuvant therapy

New results presented at the 12th European Breast Cancer Conference show that a test, which looks at the activity of 70 genes in breast cancer tissue, is possible to use in the clinic to identify patients with invasive lobular carcinoma (ILC) that is at high risk of recurring and progressing.

1 Oct 2020

Study reveals how subanesthetic ketamine is effective in treating adult amblyopia

In a new study, published in Current Biology, researchers from the University of California, Irvine School of Medicine reveal how subanesthetic ketamine, which is used for pain management and as an antidepressant in humans, is effective in treating adult amblyopia, a brain disorder commonly known as "lazy eye."

30 Sep 2020

NIH awards $5 million grant to reduce COVID-19-related health disparities

To help reduce COVID-19-related health disparities in vulnerable populations in Texas, a multi-institutional team of researchers led by The University of Texas Health Science Center at Houston will identify disease hotspots and testing deserts in three racially diverse areas, and then develop and evaluate intervention strategies to increase COVID-19 testing.

30 Sep 2020

Research shows the validity, reliability of isokinetic strength testing of older adults with COPD and stroke

The use of isokinetic dynamometers with older adults extends far beyond orthopedics, but the reliability and responsiveness of isokinetic measures in conditions like COPD and stroke are still being evaluated, report experts in Isokinetics and Exercise Science.

30 Sep 2020

Fructose intake may exacerbate inflammatory bowel disease, study reveals

Diet remains an important part of disease prevention and management, and a new study suggests that consumption of fructose may worsen intestinal inflammation common to inflammatory bowel diseases (IBD).

29 Sep 2020

Study pinpoints heating element in vaping devices as cause for lung injuries

Early results of an experimental vaping study have shown significant lung injury from E-cigarette (eC) devices with nickel-chromium alloy heating elements.

28 Sep 2020

Interdisciplinary team wins NIH grant to develop a device for early oral cancer detection

Mouth lesions are among the main early indicators of oral cancer, but determining whether a sore is actually malignant typically involves painful, costly biopsies.

28 Sep 2020

Marrowquant can quantify multiple bone components in histological images

The bone marrow is the soft tissue inside our bones. Its main role is to produce stem cells that will go on to become various cells of the blood, including white blood cells that fight infections, red blood cells that carry oxygen throughout the body, and platelets that control bleeding.

28 Sep 2020

Inhaled corticosteroids may not increase COVID-19 mortality

Inhaled corticosteroids (ICS) are the first line of treatment to counter the inflammatory pathology in several conditions, including asthma and chronic obstructive pulmonary disease (COPD). Now, a new study published in the journal The Lancet Respiratory Medicine in September 2020 reports on the actual role of ICS in reducing COVID-19 mortality.

28 Sep 2020

Human recombinant soluble ACE2 successfully used in a patient with severe COVID-19

A multinational research group recently published a paper in the journal Lancet Respiratory Medicine which describes the first patient with a severe form of coronavirus disease (COVID-19) that was successfully treated with human recombinant soluble ACE2.

27 Sep 2020

Yale designates three independent laboratories to perform SalivaDirect COVID-19 test

Yale has designated three independent laboratories to perform the university-developed SalivaDirectTM COVID-19 test.

26 Sep 2020

Pathology News and Research

Further Reading

Production of six monoclonal antibodies against SARS-CoV-2 spike protein

High levels of folic acid during pregnancy could harm brain development of embryos

Researchers receive $3.2 million to use AI for improving heart transplant outcomes

Scientists discover small molecules that may reduce cellular stress

New, rare genetic form of dementia discovered

$9.1 million NCI grant renewal will support researchers studying retrovirus cancer models

Social isolation worsens the effects of Alzheimer's disease, study shows

Researchers receive NCI grant to study role of collagens in breast cancer

Researchers identify a promising method to treat multiple sclerosis

Patients with invasive lobular carcinoma could benefit from additional adjuvant therapy

Study reveals how subanesthetic ketamine is effective in treating adult amblyopia

NIH awards $5 million grant to reduce COVID-19-related health disparities

Research shows the validity, reliability of isokinetic strength testing of older adults with COPD and stroke

Fructose intake may exacerbate inflammatory bowel disease, study reveals

Study pinpoints heating element in vaping devices as cause for lung injuries

Interdisciplinary team wins NIH grant to develop a device for early oral cancer detection

Marrowquant can quantify multiple bone components in histological images

Inhaled corticosteroids may not increase COVID-19 mortality

Human recombinant soluble ACE2 successfully used in a patient with severe COVID-19

Yale designates three independent laboratories to perform SalivaDirect COVID-19 test

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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