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Data results of NCI-MATCH trial in tumors with DNA mismatch repair deficiencies

Final results are published from an evaluation of 42 patients treated with the immune checkpoint inhibitor nivolumab in the large multi-arm precision medicine trial, NCI-Molecular Analysis for Therapy Choice (NCI-MATCH or EAY131).

20 Dec 2019

NIAID to fund VTEU program and its companion leadership group

The National Institute of Allergy and Infectious Diseases (NIAID), one of the National Institutes of Health, today announced the establishment of the Infectious Diseases Clinical Research Consortium, a clinical trials network that will encompass the Institute's long-standing Vaccine and Treatment Evaluation Units (VTEUs) and create a new consortium leadership group

20 Dec 2019

Advanced technologies can significantly improve healthcare quality, productivity, and access

Real transformation in healthcare through the adoption of artificial intelligence (AI), robotics, telecommunications, and other advanced technologies could provide significant improvements in healthcare quality, productivity, and access.

20 Dec 2019

New report highlights AI's potential to revolutionize health care

The role of artificial intelligence, or machine learning, will be pivotal as the industry wrestles with a gargantuan amount of data that could improve -- or muddle -- health and cost priorities, according to a National Academy of Medicine Special Publication on the use of AI in health care.

20 Dec 2019

Canadian First Nations communities with greater social support, trust have lower cardiac risk factors

A major study has found that Canadian First Nations communities with greater socio-economic advantages, educational opportunities, social support of family members and greater trust between community members, have lower cardiac risk factors.

19 Dec 2019

Researchers examine safety-net care for patients initiating maintenance dialysis in the U.S.

New research indicates that non-profit/independently-owned and hospital-based dialysis facilities care disproportionately for uninsured patients with kidney failure and those who quality only for Medicaid. The findings appear in an upcoming issue of JASN.

19 Dec 2019

Study finds differences in dialysis mortality for racial/ethnic groups in U.S. territories and states

A recent analysis found differences in mortality rates for various racial/ethnic groups among patients undergoing dialysis in the U.S. territories vs. the 50 U.S. states. The findings, which appear in an upcoming issue of CJASN, point to the need for research into the causes of these disparities.

19 Dec 2019

Fibroblasts involved in healing wounds play a devastating role in breast cancer development

The connective tissue cells known as fibroblasts are vitally important for our recovery from injury. Sensing tissue damage, they gravitate to the site of a wound, instigating an inflammatory response that mends damaged tissue.

19 Dec 2019

Novel 'tooth-on-a-chip' could open door to personalized dental care

A so-called "tooth-on-a-chip" could one day enable more personalized dentistry, giving dentists the ability to identify dental filling materials that work better and last longer based on a patient's own teeth and oral microbiome.

19 Dec 2019

Penn researchers use MRI scans to predict 10-year breast cancer recurrence

Diverse diseases like breast cancer can present challenges for clinicians, specifically on a cellular level. While one patient's tumor may differ from another's, the cells within the tumor of a single patient can also vary greatly.

19 Dec 2019

Almost one in two Americans will be obese by 2030

A shocking new study led by Harvard T.H. Chan School of Public Health reveals that by 2030, just a decade away, almost half of all Americans will be suffering from obesity – making this the biggest epidemic ever in history. And that’s not all – half of these obese individuals will be severely obese, or, to put it in simple terms, they will be over their expected weight by more than 100 pounds.

19 Dec 2019

New antibody shows promise in active lupus

A new trial involving the use of an antibody called anifrolumab reports improvement in patients with systemic lupus erythematosus (SLE) after 52 weeks of treatment. The research, titled 'Trial of Anifrolumab in Active Systemic Lupus Erythematosus', is published in the New England Journal of Medicine.

19 Dec 2019

Utah scientists receive NIH grant to study how air pollutants aggravate asthma in children

A multidisciplinary team of University of Utah Health scientists has received a five-year, $3 million grant from the National Institutes of variations in pollutant-sensing genes in the lungs could influence air pollution's effects on children who have asthma.

19 Dec 2019

Connection between herpes virus and Alzheimer’s refuted

A new study has shown that unlike previous claims, there is no association between getting herpes infections and developing Alzheimer’s disease. The study from the researchers at the Baylor College of Medicine was titled, “Are HHV-6A and HHV-7 really more abundant in Alzheimer’s disease?” and was published in the journal Neuron.

19 Dec 2019

Parents of children who have special health care needs more likely to be in worse health

In Chicago, 7 percent of parents said that their child or children were limited or prevented in their ability to do things most peers can do, according to the latest survey results released by Ann & Robert H. Lurie Children's Hospital of Chicago and the Chicago Department of Public Health.

19 Dec 2019

Experimental Zika vaccine improves fetal outcomes in rhesus macaque model

An experimental Zika vaccine lowered levels of virus in pregnant monkeys and improved fetal outcomes in a rhesus macaque model of congenital Zika virus infection, according to a new study in Science Translational Medicine.

19 Dec 2019

Edematous severe acute malnutrition linked to DNA modification

A group led by researchers at Baylor College of Medicine has identified significant differences at the epigenetic level - the chemical tags in DNA that help regulate gene expression - between two clinically distinct forms of acute childhood malnutrition known as edematous severe acute malnutrition (ESAM) and non-edematous SAM (NESAM).

19 Dec 2019