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Unlocking the power of mRNA vaccines: From COVID-19 to cancer and beyond

A comprehensive review in Signal Transduction and Targeted Therapy delves into the versatility and effectiveness of mRNA vaccines, from their game-changing role in COVID-19 to potential applications in cancer and rare diseases. Despite drawbacks like stability and high immunogenicity, advancements in vaccine technology have poised mRNA platforms as a robust tool for both preventive and therapeutic interventions.

21 Sep 2023

ACT and personalized cancer vaccine combo shows efficacy in ovarian cancer patients

A Ludwig Cancer Research study has shown that combining adoptive T cell therapy (ACT) with an innovative, personalized cancer vaccine under development at the Lausanne Branch of the Ludwig Institute for Cancer Research can benefit patients with late-stage, drug-resistant ovarian cancer.

21 Sep 2023

Manipulating mitochondrial electron flow enhances immune response, reduces tumor growth

Immunotherapy, which uses the body's own immune system to fight cancer, is an effective treatment option, yet many patients do not respond to it.

21 Sep 2023

Brazilian fruits positively impact gut health and chronic disease prevention

The influence of Brazilian native fruits and their by-products on human intestinal microbiota.

21 Sep 2023

USC develops innovative system for conducting preclinical research on potential stroke treatments

To test new stroke treatments, a research team from the Keck School of Medicine of USC develops a more rigorous system for conducting preclinical research that could lead to more successful clinical trials.

20 Sep 2023

Creating CAR-T cells with enhanced immune memory to fight cancer

Among available immunotherapies, the use of «CAR-T» cells is proving extremely effective against certain blood cancers, but only in half of patients.

20 Sep 2023

Doctors need better guidance on treating ADHD in over 50s

Doctors urgently need better international guidance on treating attention deficit hyperactivity disorder (ADHD) in the over 50s, conclude world-leading experts reviewing current research on this increasing issue globally.

20 Sep 2023

Study explores the efficacy of smoking interventions in new and expectant fathers

Researchers performed a review to evaluate the efficacy of behavior change interventions for smoking cessation in pregnant couples and new parents using a gendered lens.

20 Sep 2023

Unlocking the potential of the ketogenic diet: studies reveal health benefits

Researchers reported on the effects of the ketogenic diet (KD) on various aspects of metabolic and endocrinal health.

20 Sep 2023

Vaccine impact: BNT162b2 and pediatric COVID-19 ambulatory visits in kids under 5

The association between BNT162b2 vaccine and (COVID-19)-related ambulatory visits.

20 Sep 2023

Game-changing point-of-care assay could revolutionize Mpox detection worldwide

Researchers developed a point-of-care assay for the rapid detection of mpox virus.

20 Sep 2023

Subclonal neoantigens present a key roadblock in MMRd tumor immunotherapy success

Researchers evaluated sensitivity to immune checkpoint blockade (ICB) therapy.

20 Sep 2023

Transforming postpartum depression treatment with neurosteroids

A new study in Neuropsychopharmacology delves into the mechanisms of action of brexanolone, the first FDA-approved, rapid-acting antidepressant specifically for postpartum depression (PPD). The research highlights brexanolone's potential anti-inflammatory effects and its impact on GABAA receptors, offering insights into its efficacy and suggesting avenues for further study.

19 Sep 2023

High-intensity exercise may reduce colorectal cancer risk in Lynch Syndrome patients

Regular and intense aerobic exercise may reduce the risk of colorectal cancer in patients with Lynch Syndrome (LS) by improving the immune system's ability to detect and remove potentially harmful cells, according to researchers at The University of Texas MD Anderson Cancer Center.

19 Sep 2023

Research demonstrates a double-acting mechanism for fighting triple-negative breast cancer

Zachary Schug, Ph.D., assistant professor in the Molecular and Cellular Oncogenesis Program of the Ellen and Ronald Caplan Cancer Center at The Wistar Institute, has published a new paper in the journal Nature Cancer.

19 Sep 2023

Study assesses duration of protection offered by smallpox infection and possible cross-reaction with Mpox virus

More than 43 years ago, many Chinese residents were vaccinated with the vaccinia virus Tiantan strain (VTT) to protect them from smallpox infection.

19 Sep 2023

Does a high-dose influenza vaccine reduce cardiovascular disease risk?

Whether a high-dose influenza vaccine is associated with a benefit in reducing CP events.

19 Sep 2023

Trajectory of fear of cancer recurrence levels six to 18 months post-breast cancer diagnosis

Researchers examined the predictors of fear of cancer recurrence (FCR) and its trajectory among breast cancer (BC) patients.

19 Sep 2023

Stem cell therapy shows promise in treating COVID-19 complications

The use of cell therapy to treat COVID-19 patients can reduce the risk of death from the disease by 60%, according to a systematic review and meta-analysis conducted by researchers at the University of São Paulo (USP) in Brazil, in partnership with colleagues in Germany and the United States.

19 Sep 2023

Nano-based cancer therapies may be less effective in younger patients, finds study

Researchers at The University of Texas MD Anderson Cancer Center have discovered that certain nano-based cancer therapies may be less effective in younger patients, highlighting the need for further investigation into the impact of aging on the body's ability to respond to treatment.

19 Sep 2023

Efficacy News and Research

Unlocking the power of mRNA vaccines: From COVID-19 to cancer and beyond

ACT and personalized cancer vaccine combo shows efficacy in ovarian cancer patients

Manipulating mitochondrial electron flow enhances immune response, reduces tumor growth

Brazilian fruits positively impact gut health and chronic disease prevention

USC develops innovative system for conducting preclinical research on potential stroke treatments

Creating CAR-T cells with enhanced immune memory to fight cancer

Doctors need better guidance on treating ADHD in over 50s

Study explores the efficacy of smoking interventions in new and expectant fathers

Unlocking the potential of the ketogenic diet: studies reveal health benefits

Vaccine impact: BNT162b2 and pediatric COVID-19 ambulatory visits in kids under 5

Game-changing point-of-care assay could revolutionize Mpox detection worldwide

Subclonal neoantigens present a key roadblock in MMRd tumor immunotherapy success

Transforming postpartum depression treatment with neurosteroids

High-intensity exercise may reduce colorectal cancer risk in Lynch Syndrome patients

Research demonstrates a double-acting mechanism for fighting triple-negative breast cancer

Study assesses duration of protection offered by smallpox infection and possible cross-reaction with Mpox virus

Does a high-dose influenza vaccine reduce cardiovascular disease risk?

Trajectory of fear of cancer recurrence levels six to 18 months post-breast cancer diagnosis

Stem cell therapy shows promise in treating COVID-19 complications

Nano-based cancer therapies may be less effective in younger patients, finds study

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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