Clinical Trial News and Research

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Large cell therapy trial in patients with chronic heart failure shows promising results

Physician-scientists at The Texas Heart Institute announced today the results of the largest cell therapy trial to date in patients with chronic heart failure due to low ejection fraction.

27 Feb 2023

The natural history of tau accumulation and the impact of disease stage and reference region on the magnitude and effect size of regional change

Researchers performed serial tau imaging with 18F-MK6240 to detect tau accumulation in cognitively unimpaired beta-amyloid negative Alzheimer’s disease patients as well as those with mild cognitive impairment who were Aβ+ at baseline.

27 Feb 2023

High-dose ivermectin does not reduce COVID-19 symptom duration among mild-to-moderate outpatients

Researchers evaluate the efficacy of ivermectin in a maximum dosage of 600 μg/kg/day over six days in treating early mild-to-moderate COVID-19.

27 Feb 2023

Rebounding of COVID-19 symptoms and viral load are common among untreated COVID-19 patients

Researchers characterize COVID-19 symptom and viral load rebounds among untreated individuals with mild-to-moderate SARS-CoV-2 infection.

27 Feb 2023

Viable treatment option for patients with advanced cervical cancer

A recent University of Kentucky Markey Cancer Center study suggests a new radiopharmaceutical compound may be a viable treatment option for patients with advanced cervical cancer.

25 Feb 2023

Study establishes new pre-clinical model to develop clinically relevant treatments for heart attacks

CÚRAM SFI Research Centre for Medical Devices researchers have published in Nature Communications a key study establishing a new pre-clinical model to develop clinically relevant treatments for heart attacks.

24 Feb 2023

Study shows the beneficial effect of verapamil in children with newly-diagnosed type 1 diabetes

Published in JAMA, a University of Minnesota led study shows that verapamil, a drug commonly used to treat high blood pressure and heart conditions, can have a beneficial effect on the pancreas in children with newly-diagnosed type 1 diabetes (T1D).

24 Feb 2023

Study finds high doses of oral CBD can exacerbate THC’s effects by inhibiting THC metabolism

Researchers compare the pharmacokinetics and pharmacodynamics of oral Δ9-tetrahydrocannabinol-dominant and cannabidiol-dominant cannabis extracts that contained the same Δ9-THC dose (20 mg).

24 Feb 2023

Preventative antibiotic given during labor can reduce the risk of sepsis and death

A single oral dose of the antibiotic azithromycin given during labor can dramatically reduce the risk of sepsis and death among women following childbirth, according to a large multi-country clinical trial, as a UN report warns of "stagnation" in maternal health.

23 Feb 2023

Disabilities in people with heart disease underreported in clinical trials

Disabilities were underreported in clinical trial data and commonly used as a basis for exclusion from trial participation in an analysis of 80 recent trials involving cardiovascular outcomes, according to a study being presented at the American College of Cardiology's Annual Scientific Session Together With the World Congress of Cardiology.

23 Feb 2023

Minimally invasive focused ultrasound treatment improves symptoms in patients with Parkinson's disease

Patients with Parkinson's disease achieved a significant improvement in their tremors, mobility, and other physical symptoms after having a minimally invasive procedure involving focused ultrasound, according to a new study today published in the New England Journal of Medicine.

23 Feb 2023

Two newer simplified HIV treatment options found to be at least as effective as the standard of care

Two newer simplified treatment options are at least as effective as current approaches, according to the results of a world-first international clinical trial into second-line HIV therapy led by the Kirby Institute at UNSW Sydney and presented today at the Conference on Retroviruses and Opportunistic Infections in Seattle.

23 Feb 2023

Scientists identify mechanisms underlying autoimmunity in Down syndrome

Scientists at the Icahn School of Medicine at Mount Sinai in New York have identified which parts of the immune system go awry and contribute to autoimmune diseases in individuals with Down syndrome.

22 Feb 2023

First clinical trial of GABA/GAD focused exclusively on children with recent onset Type 1 diabetes

For the first time, humans with newly diagnosed Type 1 diabetes, or T1D, have received two treatments called GABA and GAD that have shown promise in animal studies and in isolated human pancreas islets. This investigator-initiated clinical trial, published in Nature Communications, focused exclusively on children with recent onset T1D.

22 Feb 2023

New analysis shows how convalescent plasma can be used as effective, low-cost COVID-19 treatment

Three years into the COVID-19 pandemic, new variant outbreaks continue to fuel economic disruptions and hospitalizations across the globe.

22 Feb 2023

Long-acting antiretroviral treatment may improve outcomes in underserved HIV patients

A long-acting antiretroviral treatment (LA-ART) given every four to eight weeks, and delivered with comprehensive support services, suppressed HIV in people who were previously not virologically suppressed.

21 Feb 2023

Skin medication shows promise in treating alcohol use disorder

Researchers from Oregon Health & Science University and institutions across the country have identified a pill used to treat a common skin disease as an "incredibly promising" treatment for alcohol use disorder.

21 Feb 2023

Testing new socialization and sex education curriculum for young people with developmental disabilities

The National Institutes of Health will award $3,906,026 over five years to researchers from the Institute for Implementation Science in Population Health at the CUNY Graduate School of Public Health and Health Policy to test the efficacy of a new socialization and sex education curriculum for young people with intellectual and developmental disabilities.

21 Feb 2023

MHRA authorizes new version of the Moderna ‘bivalent’ Covid vaccine

Authorization has today been granted by the Medicines and Healthcare products Regulatory Agency (MHRA) for a new version of the Moderna 'bivalent' Covid vaccine (Spikevax) that targets both the original strain of SARS-CoV-2 and the Omicron BA.4 and BA.5 sub-variants.

21 Feb 2023

Use of dapivirine vaginal ring during third trimester of pregnancy poses no safety concerns

A vaginal ring containing the antiretroviral drug dapivirine posed no safety concerns when used in the third trimester of pregnancy, according to results to date from the first study of the dapivirine ring during pregnancy and one of only a few studies of an HIV prevention product in pregnant cisgender women.

20 Feb 2023

Clinical Trial News and Research

Large cell therapy trial in patients with chronic heart failure shows promising results

The natural history of tau accumulation and the impact of disease stage and reference region on the magnitude and effect size of regional change

High-dose ivermectin does not reduce COVID-19 symptom duration among mild-to-moderate outpatients

Rebounding of COVID-19 symptoms and viral load are common among untreated COVID-19 patients

Viable treatment option for patients with advanced cervical cancer

Study establishes new pre-clinical model to develop clinically relevant treatments for heart attacks

Study shows the beneficial effect of verapamil in children with newly-diagnosed type 1 diabetes

Study finds high doses of oral CBD can exacerbate THC’s effects by inhibiting THC metabolism

Preventative antibiotic given during labor can reduce the risk of sepsis and death

Disabilities in people with heart disease underreported in clinical trials

Minimally invasive focused ultrasound treatment improves symptoms in patients with Parkinson's disease

Two newer simplified HIV treatment options found to be at least as effective as the standard of care

Scientists identify mechanisms underlying autoimmunity in Down syndrome

First clinical trial of GABA/GAD focused exclusively on children with recent onset Type 1 diabetes

New analysis shows how convalescent plasma can be used as effective, low-cost COVID-19 treatment

Long-acting antiretroviral treatment may improve outcomes in underserved HIV patients

Skin medication shows promise in treating alcohol use disorder

Testing new socialization and sex education curriculum for young people with developmental disabilities

MHRA authorizes new version of the Moderna ‘bivalent’ Covid vaccine

Use of dapivirine vaginal ring during third trimester of pregnancy poses no safety concerns

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