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A biomarker is a biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Also called molecular marker and signature molecule.

ESMO updates precision oncology framework to improve targeted therapies

ESMO has published version 2 of the ESMO Scale for Clinical Actionability of molecular Targets (ESCAT), a major update to the internationally recognized precision oncology framework that helps oncologists assess the clinical relevance of molecular alterations and match patients with the most appropriate targeted therapies.

22 Oct 2026

New national trial platform aims to accelerate Alzheimer's disease prevention

Researchers from the University of California San Diego will join a collaboration as part of a federal award of up to $41 million to launch a national effort aimed at accelerating the search for treatments that could prevent or slow Alzheimer's disease.

22 Oct 2026

Glucose priming may improve tumor targeting for chemotherapy nanocarriers

Chemotherapy selectivity is limited by systemic toxicity. pH‑sensitive nanocarriers exploit tumor acidity as a release trigger but respond passively to a modest, heterogeneous gradient.

21 Oct 2026

Maladaptive brain-state locking framework redefines chronic brain disorders

Neurodevelopmental, psychiatric, and neurodegenerative disorders are traditionally studied separately yet show overlapping disturbances in neural regulation and resilience.

21 Oct 2026

Could a hormone from our bones reveal early signs of insulin resistance?

Research reveals a link between osteocalcin and insulin resistance in obese children, suggesting early metabolic changes before glucose tolerance impairment.

21 Oct 2026

Combination approach slows osteosarcoma growth and prolongs survival in preclinical models

Scientists co-led by St. Jude Children's Research Hospital have identified a potential therapeutic vulnerability in some forms of osteosarcoma.

20 Oct 2026

Alzheimer’s biomarkers may help predict disease progression in ALS

Amyotrophic lateral sclerosis (ALS) is a serious neurodegenerative disease in which the nerve cells that control the body's muscles break down.

20 Oct 2026

Liquid biopsy reliably detects early-stage lung cancer recurrence risk

Despite advances in early-stage lung cancer treatment, a significant number of patients experience disease recurrence after surgery or initial therapy.

20 Oct 2026

Naturally occurring blood molecule linked to lower Alzheimer's risk

Researchers developed a drug for Alzheimer's disease, and then discovered that the molecule already exists in human blood, and is found in lower levels in cognitively impaired people.

20 Oct 2026

Discovery of new bacteria opens fresh avenues for prostate cancer research

University of East Anglia researchers have discovered the genetic blueprints of 18 new bacterial species collected from prostate cancer patients.

20 Oct 2026

Blood test could slash sepsis antibiotics

A simple daily blood test could help critically ill sepsis patients come off antibiotics sooner, potentially reducing drug overuse and helping tackle the growing threat of antibiotic resistance, new research shows.

20 Oct 2026

Voice frequency patterns reveal clues linked to type 2 diabetes

A new research study in theIEEE Journal of Biomedical and Health Informatics reveals how scientists at Klick Labs created visual maps of sound frequencies (spectrograms) to identify complex, new patterns associated with Type 2 diabetes, using only smartphone recordings of randomly selected short English sentences and participant sex as study criteria.

19 Oct 2026

Your age may not tell the whole story about your health, but your blood could

Researchers analyzed plasma metabolites from 18,476 individuals aged 1 to 96 years and developed two metabolomic aging measures to assess biological aging, chronic disease, and mortality risk. Accelerated metabolomic aging was associated with greater risks of chronic disease and death, while a separate mortality-linked measure provided additional information about health status and disease burden beyond conventional clinical assessments.

18 Oct 2026

Seragy launches with €12 million financing to advance quantitative biomarkers for neurodegenerative diseases

seragy holding GmbH (formerly Prosperodes GmbH), a biomarker strategy company focused on neurodegenerative diseases and other proteopathies, has secured €12 million in funding to accelerate the development of its SeRAS® platform (Seed Replication, Analysis and Subtyping) and expand its laboratory and analytical capabilities. The financing is backed by Commerzbank, the Mittelständische Beteiligungsgesellschaft (MBG), and the State of Lower Saxony.

14 Oct 2026

Targeting the RUNX1 gene helps reduce severe skin fibrosis

Skin fibrosis includes hypertrophic scar (HTS), keloid scar (KS), and systemic sclerosis (SSc). These conditions share persistent fibroblast activation, excessive extracellular matrix (ECM) deposition, and progressive skin remodeling.

13 Oct 2026

RNA modification enzyme FTO shows therapeutic promise in gastrointestinal cancers

A new review in Genes & Diseases highlights FTO, an enzyme involved in RNA modification, as a potentially important biomarker and therapeutic target across gastrointestinal cancers.

12 Oct 2026

Buck Institute and Georgetown lead effort mapping harmful protein changes before disease begins

A research "super team" co-led by theBuck Institute for Research on Aging and Georgetown University has received an award of up to $51.7 million from the Advanced Research Projects Agency for Health (ARPA-H) to predict how disease-causing proteins misfold before irreversible damage occurs and use those predictions to develop novel diagnostics and treatments.

12 Oct 2026

A simple handgrip test offers new clues about long COVID

Weaker handgrip strength correlates with severe long COVID symptoms, highlighting its potential as a measure for muscle dysfunction and recovery challenges.

12 Oct 2026

A study links a blood protein to memory and brain changes in Down syndrome

Researchers studying 88 adults with Down syndrome and 43 controls estimated that serum β-synuclein increased approximately two decades before expected Alzheimer’s symptoms, preceding changes in other blood biomarkers. Higher levels correlated with poorer memory and brain changes, but the cross-sectional study could not distinguish whether the earliest increase reflected Alzheimer’s-related synaptic dysfunction, trisomy 21-related neurobiology, or both.

11 Oct 2026