Carcinomas News and Research

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Uterine corpus malignancies with pregnancy-like features lead to poor survival outcomes

A new review was published in Volume 12 of Oncoscience on September 4, 2025, titled "Prognostic significance of trophoblastic differentiation and β-hCG secretion in somatic malignancies of uterine corpus: A systematic review with survival analysis."

16 Sep 2025

Repurposed diabetes drugs boost CAR T therapy effectiveness in bladder cancer

Urothelial carcinoma (UC) is the second most common genitourinary cancer, leading to over 16,000 deaths a year in the United States. Despite recent advances, the 5-year survival rate for metastatic UC remains around five to ten percent.

12 Sep 2025

Synergistic effects of radiation and immunotherapy boost anti-tumor immunity

Head and neck squamous cell carcinomas (HNSCC) are a group of cancers that affect cells in and around our mouth and nose.

29 Jul 2025

New molecular imaging agent shows high accuracy in detecting liver cancer

A novel molecular imaging agent targeting glypican-3 (GPC3) has demonstrated high sensitivity and specificity in detecting hepatocellular carcinoma (HCC), including tumors smaller than one centimeter, according to results from a pilot clinical study.

23 Jun 2025

CHAF1B drives lung squamous cell carcinoma progression by repressing SETD7

CHAF1B, a histone chaperone component of the chromatin assembly factor-1 complex, is overexpressed in multiple cancers and linked to tumor progression, but its role in lung squamous-cell carcinoma (LUSC) remained unclear.

11 Jun 2025

Loss of Y chromosome in male immune cells linked to poorer cancer outcomes

A study initiated by a University of Arizona Comprehensive Cancer Center physician-scientist defined for the first time how loss of the Y chromosome in male immune cells negatively affects immune system function, which may explain why loss of Y is associated with lower cancer survival rates.

5 Jun 2025

Enhancing early breast cancer diagnosis through modern imaging technologies

Breast cancer remains a leading cause of cancer-related mortality globally, underscoring the critical need for early detection to improve survival rates and reduce treatment invasiveness.

28 May 2025

Sylvester Cancer Center launches clinical trial for patients with high-grade neuroendocrine tumors

A clinical trial for patients with high-grade neuroendocrine tumors is now open for enrollment at Sylvester Comprehensive Cancer Center, part of the University of Miami Miller School of Medicine.

9 Apr 2025

Enfortumab vedotin and pembrolizumab show major benefits for urothelial carcinoma patients

Urothelium is the term for the mucous membrane that lines the urinary tract. This includes the renal pelvis, ureter, urinary bladder and the upper part of the urethra. In the vast majority of cases, urothelial carcinomas grow in the bladder (bladder carcinoma).

4 Apr 2025

Enhancing skin cancer screening with 3D imaging technology

The potential for 3D photography to improve melanoma early detection is a topic of increasing interest in the medical community.

27 Mar 2025

Combination immunotherapy improves treatment response for head and neck cancer

Researchers conducting a clinical trial of immunotherapy drugs for people with head and neck squamous cell carcinomas (HNSCCs) found that patients responded better to a combination of two immunotherapies than patients who received just one immunotherapy drug.

13 Mar 2025

UC San Diego researchers discover new way to predict breast cancer spread

By assessing how "sticky" tumor cells are, researchers at the University of California San Diego have found a potential way to predict whether a patient's early-stage breast cancer is likely to spread.

5 Mar 2025

Pancreatic cancer reprograms nerve cells to fuel growth

Pancreatic cancer is fueled by connections to the nervous system. This is reported by scientists from the German Cancer Research Center (DKFZ) and the Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM) in their current publication in Nature.

17 Feb 2025

Immunotherapy reduces sunspots and skin cancer by 65%

University of Queensland researchers have discovered immunotherapy, when used to treat people with advanced cancers, also helps reduce sunspots and skin cancers by at least 65 per cent.

12 Feb 2025

Mayo Clinic develops AI tool to visualize complex biological data

Mayo Clinic researchers have pioneered an artificial intelligence (AI) tool, called OmicsFootPrint, that helps convert vast amounts of complex biological data into two-dimensional circular images.

6 Feb 2025

New therapy shows promise in treating basal cell carcinoma

Basal cell carcinomas, the most common form of skin cancer, occur in chronically sun-exposed areas such as the face.

27 Jan 2025

Researchers investigate a new combination therapy against cancer

A research team at the Medical University of Vienna led by Maria Sibilia has investigated a new combination therapy against cancer.

23 Jan 2025

Topical immunotherapy clears precancerous skin lesions and reduces cancer risk

Calcipotriol-plus–5-FU therapy activates immune pathways, offering long-lasting protection against squamous cell carcinoma by targeting precancerous lesions.

6 Jan 2025

Global study reveals shifting trends in ovarian cancer incidence by subtype and region

Study analyzed global patterns and trends in ovarian cancer incidence from 1988 to 2017, highlighting variations by histological subtypes and regions. It revealed significant geographic disparities, with higher rates in regions with very high HDIs and emphasized the need for targeted prevention and surveillance strategies.

15 Dec 2024

p53 mutations show diverse impact on pancreatic cancer metabolism

A research team at the University of Konstanz, led by toxicologist Ivano Amelio, has demonstrated how differently individual mutations of the tumor suppressor p53 affect pancreatic carcinomas.

6 Dec 2024