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Organoid coculture platforms enhance preclinical prediction of drug efficacy

Three‐dimensional cancer organoids cultured in vitro closely recapitulate the phenotypic and genetic features of parental tumor tissues, making them powerful tools for cancer research, drug screening, and personalized medicine.

5 Nov 2026

Three-drug combination remodels immune environment in gastric cancer

A triplet combination therapy can remodel the tumor microenvironment in patients with advanced gastric cancer and shows a promising safety profile, according to results from a new phase 2 clinical trial.

5 Nov 2026

UCLA advances CRISPR gene-editing therapy for sickle cell disease

A UCLA-led team has described how they advanced an experimental CRISPR approach for sickle cell disease into a blood stem cell therapy that can be manufactured at the scale and quality required for a clinical trial.

4 Nov 2026

Modern lifestyles may be changing our gut bacteria in unexpected ways

A global study of 1,015 adults across 12 countries found that industrialized lifestyles were associated with lower gut bacterial diversity, reduced microbial community stability, and increased markers of intestinal stress and immune activity. The researchers also found that a microbiome-based health index developed using industrialized populations performed poorly in less-industrialized communities, raising concerns about its applicability across diverse populations.

4 Nov 2026

Faulty cellular recycling may link pulmonary arterial hypertension to brain damage

A commentary in The Journal of Clinical Investigation examines evidence linking pulmonary arterial hypertension (PAH) to cerebellar abnormalities, focusing on impaired lysosomal lipid metabolism, oxysterol accumulation, and microglial inflammation. Findings from human imaging, mouse models, and cultured cells suggest that NCOA7 may help protect against these changes, although the proposed mechanisms and therapeutic implications require further investigation.

4 Nov 2026

Comprehensive genetic map offers new hope for tuberculosis treatments

Rockefeller scientists have created the most comprehensive map to date of how essential genes interact in Mycobacterium tuberculosis (Mtb), the bacterium responsible for tuberculosis (TB).

4 Nov 2026

Deep learning method maps spatial architecture of brain cancer cells

Glioblastoma is the deadliest and most common type of malignant brain tumour in adults. One of the reasons it's almost always incurable is that individual tumour cells are very different from one another and shift dynamically between various 'states'.

4 Nov 2026

Researchers identify specific gene linked to female protection from autism

In many cases all it takes is one mutated gene to orchestrate changes across a whole network of genes linked to autism, according to new results published today in Nature by researchers at Boston Children's Hospital.

4 Nov 2026

Targeted nanoimmunotherapy reduces atherosclerotic plaque burden in mice

This new article publication from Acta Pharmaceutica Sinica B discusses a targeted nanoimmunotherapy designed to restore macrophage clearance of dying cells, promote an anti-inflammatory phenotype, and reduce atherosclerotic plaque burden in mice.

4 Nov 2026

Genetic variant tied to liver injury from blood pressure drugs

This new article publication from Acta Pharmaceutica Sinica B discusses the clinical features and genetic associations of rare liver injury caused by antihypertensive medications.

4 Nov 2026

Protein DUSP4 prevents immune cell exhaustion in colorectal cancer

The immune system has powerful cells that can recognize and destroy cancer, but this ability can gradually wane when the cells reside within a tumor.

4 Nov 2026

Researchers develop method to generate billions of cDC1 immune cells

Conventional type 1 dendritic cells, known as cDC1 cells, are immune cells that help initiate responses against intracellular pathogens and tumors.

4 Nov 2026

Researchers uncover how astrovirus spreads without destroying gut cells

Among the various viruses that sicken your gut, some at least leave behind a tiny path of cellular destruction as they replicate, implicating the guilty pathogen.

3 Nov 2026

AlphaFold3 reveals molecular interactions driving T cell recognition

Researchers at the Translational Genomics Research Institute (TGen), part of City of Hope, have developed a new approach using the artificial intelligence platform AlphaFold3 to predict whether a T cell receptor will recognize a specific antigen based solely on its genetic sequence.

3 Nov 2026

Engineered beneficial bacteria reduce bloodstream infections after stem cell transplants

Researchers at City of Hope®, one of the largest and most advanced cancer research and treatment organizations in the country, and collaborators have pioneered a new approach to preventing dangerous bloodstream infections in patients receiving donor stem cell transplants for blood cancers.

3 Nov 2026

Synthetic DNA molecules enable precise targeting of cancer-linked genes

Researchers have developed a promising new approach that uses synthetic DNA molecules to target cancer-linked genes directly, opening new possibilities for future treatments, diagnostics and biological research.

3 Nov 2026

Study reveals how breast milk sugar may help protect infants against jaundice

A new study by researchers at the University of California San Diego School of Medicine sheds light on the role of breast milk in supporting intestinal development and preventing hyperbilirubinemia, a condition in which bilirubin, a waste product from broken-down red blood cells, builds up in the blood and causes yellowing of the skin and eyes known as jaundice.

3 Nov 2026

Natural plant extract reduces cisplatin-induced kidney injury in mice

Acute kidney injury is common in hospitalized patients and rises sharply in intensive care, yet treatment options remain largely supportive.

3 Nov 2026

Compounds that give citrus fruits their scent may affect gut health

A review published in Food & Function found that dietary terpenoids, naturally occurring compounds in fruits, herbs, and vegetables, can suppress inflammatory signalling and improve intestinal barrier function in laboratory and animal studies. However, human evidence remains limited to two small studies of geraniol-based interventions for irritable bowel syndrome, with further research needed to establish clinical efficacy, appropriate dosing, and long-term safety.

3 Nov 2026

Vanderbilt researchers create massive transcriptomic atlas of breast cancer

A new molecular map of breast cancer has identified novel forms of the disease and provides a foundation for selecting personalized treatments guided by a tumor's molecular characteristics rather than standard pathology alone.

3 Nov 2026