Cytochrome P450 News and Research

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ANXA2 positive hepatocytes drive migration based repair in acute liver failure

Acute liver failure (ALF) represents a life-threatening condition marked by rapid deterioration of liver function, often necessitating urgent liver transplantation.

18 Jul 2025

Optibrium partners with TalTech on EU-funded PhD program to advance sustainable drug discovery

Optibrium, a leading developer of software and AI solutions for molecular design, today announced its partnership with TalTech (Tallinn University of Technology) to co-supervise an EU-funded PhD position as part of the INNOCHEMBIO programme.

2 Jul 2025

Do spicy foods help or hurt your gut health?

Capsaicin, the spicy compound in chili peppers, not only influences inflammation, metabolism, and cancer risk but also shapes the gut microbiome in complex, context-dependent ways. This comprehensive review highlights both the therapeutic promise and potential risks of capsaicin, calling for deeper research into its microbiome-mediated effects.

26 Jun 2025

Blocking a single enzyme rewires limb regrowth in axolotls

Researchers uncovered how CYP26B1-mediated retinoic acid (RA) breakdown determines segment identity during axolotl limb regeneration. Disrupting RA degradation reprograms blastema cells, revealing the molecular controls of precise limb regrowth.

11 Jun 2025

Gut bacteria and diet found to affect cancer treatment outcomes

A Ludwig Cancer Research study has uncovered a surprising link between diet, intestinal microbes and the efficacy of cancer therapy.

22 May 2025

New rifamycin drugs fight antibiotic-resistant lung infections more effectively

Researchers have developed next-generation rifamycin analogs that effectively kill both replicating and nonreplicating Mycobacterium abscessus while minimizing drug-drug interactions. Lead candidates UMN-120 and UMN-121 showed superior efficacy to current treatments in mouse models and retained potency against M. tuberculosis.

5 May 2025

Can natural supplements backfire? Review explains how and why

A new review uncovers how common natural supplements can both protect and endanger health, depending on dose, duration, and delivery—and points to next-gen technologies as the key to unlocking their full therapeutic power.

31 Mar 2025

New review maps the impact of reproductive hormones on neurological health

A comprehensive review published today in Brain Medicine by leading neuroendocrinologist Professor Hyman M. Schipper from McGill University's Department of Neurology and Neurosurgery maps out the extensive influence of reproductive hormones on neurological health and disease.

18 Feb 2025

Targeting ferroptosis for overcoming chemoresistance in digestive tract tumors

The global burden of digestive tract tumors is profound, with these cancers accounting for nearly half of all malignant tumors worldwide.

8 Nov 2024

Glutathione found to significantly reduce acetaldehyde levels and help relieve hangovers

Study demonstrates that glutathione (GSH) significantly reduces acetaldehyde levels, a key factor in hangovers, though subjective symptoms showed little difference between groups. Pharmacokinetic data indicate that GSH accelerates acetaldehyde clearance, providing potential relief from hangover symptoms.

29 Sep 2024

Austocystin D's anticancer efficacy linked to CYP2J2 enzyme activity

Austocystin D, a natural compound produced by fungi, has been recognized for its cytotoxic effects and anticancer activity in various cell types. It exhibits potent activity even in cells that express proteins associated with multidrug resistance, attracting significant global research interest.

27 Aug 2024

PUFA metabolites in umbilical cord blood may predict autism spectrum disorder

Autism spectrum disorder (ASD) is a neurodevelopmental disorder that affects learning capability and social behavior of people.

29 Jul 2024

Natural antioxidants could delay age-related decline in male testosterone production

Natural polyphenolic compounds to enhance testosterone production and prevent age-related hypogonadism in aging males.

12 Jun 2024

St. Jude researchers unveil mechanisms to block PXR and enhance drug potency

Deaths from cancer or infections can occur when available treatments are ineffective. Once turned on, pregnane X receptor (PXR) activates the expression of genes encoding enzymes that metabolize external chemicals, including drugs.

14 May 2024

Researchers unveil digital 'alcohol twin' to predict drinking risks and guide personalized interventions

Digital twin model simulates real-life alcohol consumption patterns and links them to long-term biomarkers, aiding eHealth strategies to curb dangerous drinking habits. The model captures complex physiological interactions between food, beverages, and alcohol metabolism.

9 May 2024