Ibuprofen News and Research

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Ibuprofen is a drug used to treat fever, swelling, pain, and redness by preventing the body from making a substance that causes inflammation. It is a type of nonsteroidal anti-inflammatory drug (NSAID). Ibuprofen is a propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic effects. Ibuprofen inhibits the activity of cyclo-oxygenase I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes. This leads to decreased prostaglandin synthesis, by prostaglandin synthase, the main physiologic effect of ibuprofen. Ibuprofen also causes a decrease in the formation of thromboxane A2 synthesis, by thromboxane synthase, thereby inhibiting platelet aggregation.

Over-the-counter pain relievers outperform opioids after wisdom tooth extraction

Over-the-counter pain medications work as well or better than opioids after wisdom tooth extraction for both men and women, according to a Rutgers Health-led follow-up to a landmark paper on comparative pain relief.

6 Nov 2025

Cannabis extract eases chronic back pain and improves quality of life in major clinical trial

A phase 3 trial in Nature Medicine found that a full-spectrum Cannabis sativa extract (VER-01) significantly reduced chronic low back pain and improved sleep and function compared with placebo. The extract was safe, well-tolerated, and showed no signs of abuse or dependence, with benefits maintained over long-term treatment.

30 Sep 2025

Discovery of EP2 receptor opens path to pain relief without blocking inflammation

Scientists at the NYU Pain Research Center have identified which receptor in prostaglandins-the hormone-like substance targeted by common painkillers-causes pain but not inflammation.

25 Sep 2025

Trump claims ‘no downside’ to avoiding Tylenol during pregnancy. He’s wrong.

Obstetricians have long advised their pregnant patients that Tylenol is the safest option to reduce fever or pain. President Donald Trump stood before a national audience on Sept. 22 and contradicted that.

24 Sep 2025

Gait retraining reduces pain and slows knee damage in osteoarthritis

Nearly a quarter of people over the age of 40 experience painful osteoarthritis, making it a leading cause of disability in adults.

1 Sep 2025

How do common painkillers drive stronger E. coli resistance?

Research shows that non-antibiotic medications like ibuprofen can enhance E. coli mutations, raising concerns about antimicrobial resistance in older adults.

29 Aug 2025

Common painkillers ibuprofen and paracetamol found to fuel antibiotic resistance

Ibuprofen and paracetamol are common over-the-counter medications that many of us reach for when we're sick. But new research from the University of South Australia shows that these trusted staples are quietly fuelling one of the world's biggest health threats: antibiotic resistance.

25 Aug 2025

Personalized gait retraining reduces pain and slows knee damage in osteoarthritis

Nearly a quarter of people over the age of 40 experience painful osteoarthritis, making it a leading cause of disability in adults.

12 Aug 2025

Tracking counterfeit medicines through chemical fingerprints

Medicines have a unique chemical fingerprint, according to a new study from the University of Copenhagen. Researchers say this knowledge can be used to trace counterfeit or stolen medicine.

7 Aug 2025

Covid-19 pandemic linked to accelerated brain aging

A new study, led by experts at the University of Nottingham, has found that the Covid-19 pandemic may have accelerated people's brain health, even if they were never infected with the virus.

22 Jul 2025

New insights reveal how the immune system fights intestinal parasites

New research from the University of Pittsburgh reveals how the immune system defends against intestinal parasitic worms, or helminths, one of the most common infections worldwide in communities with limited access to clean water and sanitation.

22 Jul 2025

How a simple blood test can forecast future health risks

Plasma proteomics reveals that the biological ages of key organs, especially the brain and immune system, strongly predict the risk of future disease and early death. These organ-specific “clocks” provide a new tool for identifying those at highest risk and personalizing preventive care.

10 Jul 2025