Immunohistochemistry News and Research

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Immunohistochemistry (IHC) is an imaging technique to visualize antigens in cells. Labeled antibodies bind to target antigens in the cell to image the distribution and localization of specific proteins of interest

Targeting IGF2BP2 improves anti-angiogenic therapy effectiveness in colorectal cancer

A recent study published in Engineering has shed light on a novel therapeutic target for improving anti-angiogenic treatment in colorectal cancer (CRC).

10 Mar 2026

Novel microneedle patch accelerates healing of chronic diabetic wounds using light

Researchers from Nanjing Drum Tower Hospital, Southeast University, and Wenzhou Medical University have developed a novel microneedle patch that combines MXene hydrogel with nitric oxide (NO) and hypoxia-inducible factor-1α (HIF-1α) plasmid for enhanced diabetic wound treatment.

10 Mar 2026

Protein aggregates in the liver may protect against alcohol-induced damage

Alcohol-associated liver disease (ALD) remains a leading cause of cirrhosis and liver-related mortality worldwide, with few effective therapies.

9 Mar 2026

FOXJ3 gene identified as the critical link between abnormal brain development and epilepsy

Researchers have discovered that mutations in the FOXJ3 gene act as a "master switch" failure, disrupting how the brain builds its layers and leading to FCD, a primary cause of drug-resistant epilepsy.

9 Mar 2026

Case report describes treatment of rare calcified solid pseudopapillary pancreatic tumor

A new case report was published in Volume 13 of Oncoscienceon February 7, 2026, titled "Massive calcified solid pseudopapillary neoplasm of the pancreatic head."

6 Mar 2026

Virtual immunostaining method improves detection of vascular invasion in thyroid cancer

In a groundbreaking study published in BME Frontiers, researchers from the University of California, Los Angeles (UCLA), in collaboration with international partners, have developed a deep learning-based virtual multiplexed immunostaining (mIHC) method.

6 Mar 2026

Distinct spatial tumor–immune ecosystems predict lung cancer treatment response

Researchers at Moffitt Cancer Center have identified distinct spatial tumor–immune ecosystems that predict whether patients with advanced non–small cell lung cancer will benefit from immunotherapy.

5 Mar 2026

ATG14 found to be a critical defender against hepatic injury and fibrosis

Autophagy is indispensable for maintaining hepatocyte integrity, metabolic homeostasis, and survival. While several autophagy-related proteins have been studied in hepatic physiology, the specific role of Autophagy Related 14 (ATG14) in liver health has remained unclear.

24 Feb 2026

Preoperative combination treatment shows promise for some patients with pancreatic cancer

A new UCLA investigator-initiated study sponsored by the UCLA Health Jonsson Comprehensive Cancer Center has found that adding immunotherapy to standard chemotherapy before surgery is safe and shows promise for some patients with borderline-resectable pancreatic cancer, a disease that has historically been difficult to treat.

17 Feb 2026

Characteristic features of bone marrow metastasis from non-hematolymphoid malignancies

Bone marrow metastasis (BMM) from non-hematolymphoid malignancies with resultant cytopenia(s) can mimic primary hematolymphoid disorders. This study aimed to investigate the clinical and pathological characteristics of BMM from non-hematopoietic tumors.

30 Jan 2026

Understanding sevoflurane-induced neurogenesis inhibition and cognitive dysfunction in children

Every year, millions of infants and children undergo surgery under general anesthesia in the world. Sevoflurane is a commonly used pediatric anesthetic. Its exposure during brain development has been shown to inhibit neurogenesis and cause cognitive dysfunction in animal models.

5 Jan 2026

AI turns routine pathology slides into powerful maps of the tumor immune landscape

A large study shows that routine H&E pathology slides contain rich spatial proteomic signals that can be decoded by AI to model the tumor immune microenvironment at population scale. By generating virtual multiplex immunofluorescence images, GigaTIME enables pan-cancer discovery of immune patterns linked to invasion stage, survival, and genomic alterations.

10 Dec 2025

Automated production of lung organoids could revolutionize the development of treatments

A team of scientists have developed a simple method for automated manufacturing of lung organoids which could revolutionize the development of treatments for lung disease.

1 Dec 2025

Arginine slows amyloid buildup and improves brain outcomes in Alzheimer’s disease models

Arginine reduced amyloid beta aggregation in vitro and in both Drosophila and AppNL-G-F mouse models of Alzheimer’s disease, leading to fewer dense-core plaques and improved behavior. The study provides preclinical evidence that oral arginine may modulate amyloid pathology, although high dosing requirements and model limitations constrain human translation.

24 Nov 2025

Study finds GLP-1 drugs improve strength and reverse aging biology in mice

Researchers showed that GLP-1 receptor agonism counteracts aging across multiple organs in mice, improving strength and reversing molecular aging signatures without meaningful effects on body weight. These benefits depended largely on hypothalamic GLP-1R signaling and closely mirrored the anti-aging patterns produced by rapamycin.

23 Nov 2025

Single-cell analysis reveals HPV-induced keratinocyte heterogeneity in cervical cancer

Cervical squamous cell carcinoma (CESC), the most prevalent subtype of cervical cancer, remains a major global health burden driven primarily by persistent high-risk HPV infection and genetic susceptibility.

7 Nov 2025

Runx1 overexpression triggers early intervertebral disc degeneration

A new research paper was published in Volume 17, Issue 9 of Aging-US on September 8, 2025, titled, "Runx1 overexpression induces early onset of intervertebral disc degeneration."

17 Oct 2025

What happens when microplastics reach the testes? Study shows autophagy and cell loss

Researchers found that microplastics from everyday plastic tableware accumulate in human semen and, although not linked to semen quality in the full cohort, were associated with altered sperm parameters in specific subgroups. Experimental models confirmed that 50 nm polystyrene particles trigger autophagy and apoptosis via the FOXA1/MAP3K1/p38 pathway, impairing sperm structure and function.

15 Oct 2025

Empowering genomics research with cloud-based innovation

Discover how Discovery Life Sciences enhances genomics research with cloud-based platforms like DNAnexus.

From DNAnexus, Inc. 8 Oct 2025

Long COVID linked to heavier periods and symptom flare-ups during menstruation

Researchers found that long COVID is linked to heavier, longer, and more irregular bleeding without disrupting ovulation. Symptom severity also peaks around menstruation, likely driven by hormonal and immune changes.

17 Sep 2025