International Classification of Diseases News and Research

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Global health progress reversing in several critical areas, WHO warns

While there have been meaningful improvements in global health over the past decade, with millions benefiting from better prevention, treatment and access to essential services, persistent and emerging challenges mean that the world remains off track to achieve any of the health-related Sustainable Development Goals (SDGs) by 2030.

13 May 2026

Maternal weight before pregnancy may shape toddlers’ development

A nationwide Korean cohort study of 258,367 mother-child pairs found that maternal pre-pregnancy BMI was associated with developmental delay risk in children aged 18 to 36 months. Children of underweight mothers showed modest early risks that later attenuated, while obesity-related risks persisted across developmental domains.

29 Apr 2026

TikTok chatter could help predict where the opioid crisis is heading next

A large-scale analysis of 569,581 TikTok comments found that opioid-related discussions may help track and forecast synthetic opioid overdose mortality in the US. Recovery, harm reduction, drug use, drug sourcing, and loss-related conversations provided near-real-time signals that improved 6-month forecasting accuracy.

28 Apr 2026

Large US study finds never-married adults face higher risk for most major cancers

A large US population-based study found that never-married adults had higher cancer incidence than ever-married adults across most cancer types, with the largest disparities seen in older adults and in Black men. The pattern was especially strong for HPV-related, tobacco-related, and several reproductive cancers, suggesting marital status may act as an important social marker of cancer risk.

9 Apr 2026

Researchers track how youth drinking deaths changed worldwide over 31 years

A global analysis of GBD 2021 data found that youth drinking contributed to 417,198 deaths across 194 WHO member countries and territories between 1990 and 2021, with deaths declining from 13,346 to 10,563 over the period. Boys and young men bore a far higher burden, and most alcohol-attributable deaths were linked to transport injuries, interpersonal violence, and self-harm, with marked disparities across SDI levels and countries.

6 Apr 2026

High-dose flu shots inked to lower Alzheimer's dementia risk in older adults

A large US claims-based study found that adults aged 65 and older who received a high-dose flu vaccine had a lower observed risk of Alzheimer dementia than those who received a standard-dose vaccine, with the association lasting up to 25 months in per-protocol analyses and 28 months in intention-to-treat analyses. The signal appeared stronger and more sustained in women, though the authors stress that the findings are observational and need confirmation in longer prospective studies.

2 Apr 2026

Study links social media addiction to worse student mental health and points to family as a key buffer

A study of 627 Saudi university students found that higher social media addiction was associated with more anxiety and depression, while family environment fully mediated those links in the statistical model. The findings suggest that supportive family relationships may help buffer the mental health burden associated with problematic social media use, although the cross-sectional design does not establish causation.

25 Mar 2026

New review calls for biologically grounded approach to psychiatric diagnosis

A comprehensive invited review published today in Brain Medicine confronts one of the most persistent paradoxes in modern medicine: psychiatry remains the only major clinical discipline that diagnoses complex illness primarily through conversation and symptom checklists, while fields such as oncology and cardiology long ago embraced laboratory markers, imaging, and molecular profiling.

10 Mar 2026

Specific gut bacteria may signal long-term risk of heart and metabolic disease

Researchers analyzed gut microbiome profiles from 4,792 adults in the HELIUS cohort and tracked cardiometabolic outcomes over time to determine whether specific microbes predict disease risk. Certain microbes were linked to higher or lower cardiovascular risk, while plant-derived microbial metabolites suggested potential diet–microbiome interactions influencing heart health.

9 Mar 2026

Are socially isolated people more likely to develop cancer? Study of 350,000 adults explores the risk

A large UK Biobank study of more than 350,000 adults found that social isolation, but not loneliness alone, was associated with a modest increase in overall cancer risk during over 11 years of follow-up. The association was stronger in women and appeared partly linked to socioeconomic disadvantage, unhealthy behaviors, and inflammatory processes.

3 Mar 2026

Can brain training prevent dementia? Long-term trial shows speed training with boosters makes a difference

A 20-year follow-up of older adults in the ACTIVE randomized trial linked to Medicare claims found that speed of processing cognitive training with booster sessions was associated with a significantly lower risk of diagnosed Alzheimer’s disease and related dementias. Memory and reasoning training did not show comparable long-term reductions in dementia risk.

2 Mar 2026

Accelerating rare disease diagnosis with Mondo

Coryssa Barnes, of Henderson, N.C., welcomed her first child, Ezra, in 2020. At four months old, he was unable to sit without support. As time went on, he failed to reach other developmental milestones, prompting his worried parents to consult several medical experts.

2 Mar 2026

COVID-19 initially reduced asthma attacks but widened socioeconomic disparities, study finds

A large retrospective study of more than 162,000 asthma patients in the Bronx found that asthma exacerbations dropped sharply after the onset of COVID-19 before rebounding in children but remaining lower in adults. Socioeconomic disparities widened during the pandemic, particularly among Medicaid recipients, certain income groups, and patients with documented unmet social needs, while racial and ethnic gaps persisted without significantly expanding.

25 Feb 2026

Mental health struggles in first year of cancer care predict worse outcomes

This study reveals a strong association between early mental health disorders in cancer patients and increased all-cause mortality, highlighting care needs.

25 Feb 2026

Eating fewer foods of concern may protect the heart beyond pills

A prospective cohort study in adults with hypertension and or hypercholesterolemia found that lower intake of ultra processed foods or foods flagged by front of pack nutrition warnings was associated with reduced cardiovascular disease risk. These associations persisted regardless of cardioprotective medication use, suggesting dietary quality contributes independently to cardiovascular prevention.

10 Feb 2026

Study suggests shingles vaccine may help lower Alzheimer’s and dementia risk

A large observational electronic health record study found that older adults receiving the recombinant zoster vaccine showed substantially lower rates of diagnosed dementia compared with matched unvaccinated individuals. The association persisted after multiple sensitivity analyses, although causality remains unproven and longer follow-up is required given the long latency of dementia.

10 Feb 2026

Common food preservatives may raise cancer risk

Higher intake of certain food preservatives is associated with increased cancer rates, particularly breast and prostate cancers, highlighting safety concerns.

13 Jan 2026

Common blood signals explain why chronic diseases cluster as we age

This population-based study shows that shared and pattern-specific blood biomarkers reflect biological vulnerability underlying multimorbidity and the pace at which chronic diseases accumulate in older adults. Metabolic and systemic stress markers such as GDF15, HbA1c, cystatin C, and insulin consistently tracked higher disease burden and faster accumulation, with findings replicated across cohorts.

5 Jan 2026

High-fat cheese and cream consumption links to lower dementia risk over 25 years

Higher intake of high-fat cheese and cream was associated with a lower risk of all-cause dementia over 25 years in a large Swedish cohort, while low-fat dairy showed no association. Associations were strongest for vascular dementia and among APOE ε4 non-carriers, with findings remaining observational.

23 Dec 2025

Rethinking Mendelian assumptions in inherited retinal degenerations

A new study challenges what's long been assumed about genetic variants thought to always cause inherited blindness.

22 Dec 2025