Opioids News and Research

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An opioid is a chemical that works by binding to opioid receptors, which are found principally in the central nervous system and the gastrointestinal tract. The receptors in these two organ systems mediate both the beneficial effects and the side effects of opioids.

New national program targeting harmful and unnecessary medicine use in Australia

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1 Jul 2026

Melatonin may safely reduce chronic musculoskeletal pain, study finds

A sleep supplement widely used to treat insomnia could help reduce reliance on some of the most common and potentially harmful pain medications, new research from the University of Sydney suggests.

30 Jun 2026

Naloxone provides life-saving tool to reverse opioid overdoses

Anyone can save a life during an opioid overdose with naloxone, a front-line defense in the nation's overdose crisis.

16 Jun 2026

Experimental vaccine protects against fentanyl and related opioids

Fentanyl and related variants of the synthetic opioid kill more Americans each year than car accidents and gun violence combined. In too-high doses, the drugs hijack brain chemistry and shut down the signals that control breathing.

11 Jun 2026

Falling fentanyl deaths drive historic drop in American drug overdoses

Researchers from the University of California San Diego have found that U.S. overdose death rates declined dramatically between 2023 and 2024, marking the first recorded drop in all four waves of the nation's overdose crisis.

2 Jun 2026

Nerve freezing technique reduces pain after surgical repair for microtia

Ann & Robert H. Lurie Children's Hospital of Chicago is the first in the world to eliminate months of pain after surgical repair for microtia – a rare condition where a child is born with underdeveloped or missing outer ear.

26 May 2026

GLP-1 drugs may help curb addiction by targeting reward pathways

GLP-1 receptor agonists, already used for Type 2 diabetes and obesity, show promise in reducing alcohol and drug-seeking behaviors through central reward and dopamine-related pathways. Most evidence remains preclinical, with limited early human data, so larger clinical trials are needed before these drugs can be recommended for addiction treatment.

21 May 2026

Study links pediatric sedation strategies with later neurocognitive outcomes

A new Penn Nursing study suggests that the specific sedatives used during critical illness in early childhood may have long-term implications for a child's neurocognitive development.

19 May 2026

Opioid-related infections linked to rising amputation rates across United States

Severe infections linked to opioid use often progress rapidly, particularly when access to timely medical care is limited. This can result in devastating health outcomes, including life-altering amputations.

19 May 2026

Endometriosis increases risk of some birth defects in infants

Research indicates women with endometriosis may face a higher risk of congenital anomalies in infants, emphasizing the need for further investigation.

13 May 2026

NIH awards $3.9 million grant to develop a non-opioid pain treatment

The National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health (NIH), has awarded a $3.9 million grant to a multi-institutional team led by scientists at Sanford Burnham Prebys Medical Discovery Institute to develop a non-opioid pain therapeutic and advance it into a Phase 1 clinical trial.

4 May 2026

TikTok chatter could help predict where the opioid crisis is heading next

A large-scale analysis of 569,581 TikTok comments found that opioid-related discussions may help track and forecast synthetic opioid overdose mortality in the US. Recovery, harm reduction, drug use, drug sourcing, and loss-related conversations provided near-real-time signals that improved 6-month forecasting accuracy.

28 Apr 2026

New clinical guidelines significantly reduce opioid prescriptions after ear surgery

A new retrospective study published in OTO Open, the open-access journal of the American Academy of Otolaryngology–Head and Neck Surgery Foundation (AAO-HNSF), demonstrates that the Clinical Practice Guideline (CPG) Opioid Prescribing for Analgesia After Common Otolaryngology Operations has had a measurable and sustained impact on prescribing practices following parotidectomy, which a surgical procedure to remove the parotid gland.

28 Apr 2026

U.S. dentists still prescribe opioids at higher rates globally

People getting their teeth pulled or drilled by dentists in the United States are still much more likely to get powerful opioid medications than dental patients in other developed countries or even the U.S. territory of Puerto Rico, a new study finds.

23 Apr 2026

UCL study urges clinician vigilance when prescribing gabapentinoids for pain

People who take gabapentinoids, a medication prescribed increasingly frequently worldwide, particularly for chronic pain, face a much greater risk of drug poisoning if they are also taking another medication, finds a new study by University College London (UCL) researchers.

17 Apr 2026

Prenatal opioid exposure shows minimal effect on later academic performance

Every 25 minutes in the United States, a baby is diagnosed with neonatal abstinence syndrome (NAS), a condition that occurs in newborns who have been exposed to opioids in the womb and develop withdrawal after birth, according to the Centers for Disease Control and Prevention.

13 Apr 2026

Standard naloxone doses may not reverse newer synthetic opioid overdoses

A new study exposes challenges in reversing opioid overdoses with naloxone when potent synthetic drugs like fentanyl and sufentanil are involved, according to a study in the May 2026 issue of Anesthesiology, the peer-reviewed medical journal of the American Society of Anesthesiologists (ASA).

13 Apr 2026

New brain circuit discovery offers hope for chronic pain treatment

A new map of a brain circuit specific to chronic pain suggests a promising route to treatment for the roughly 60 million Americans living with persistent pain, according to a study published in Nature.

1 Apr 2026

Highly potent opioid shows potential as therapy for pain and opioid use disorder

Researchers at the National Institutes of Health (NIH) have identified a novel, highly potent opioid that shows potential as a therapy for both pain and opioid use disorder.

1 Apr 2026

Study finds addiction risk tied to reward and impulse genes

Most of the genetic risk for developing a substance use disorder comes from genes that broadly affect how our brains process rewards, regulate impulses and weigh consequences – not from genes that specifically influence substance use disorder or any single drug.

22 Mar 2026