Single Nucleotide Polymorphisms News and Research

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Researchers link genetic ancestry to severity of dengue fever

For the first time, the extreme variability in dengue fever has been linked to a biological mechanism, potentially opening doors to new treatments and vaccines for the most common mosquito-borne disease worldwide.

30 Jun 2025

Harnessing saliva for precision medicine and early disease diagnosis

A research team led by the University of the Basque Country (Euskal Herriko Unibertsitatea, EHU) has identified hundreds of molecular markers in saliva that could reveal the risk of a person developing major diseases such as cancer, cardiovascular diseases, diabetes and neurodegenerative diseases.

26 Jun 2025

Why Alzheimer’s DNA tests don’t treat all populations equally

A major global study tested whether European-derived polygenic risk scores (PGS) for Alzheimer’s disease can predict risk across diverse populations. While PGS performed well in many groups, it was less accurate in individuals of sub-Saharan African and Indian ancestry, highlighting the urgent need for more inclusive genetic data.

19 Jun 2025

Instant coffee may damage your eyes, genetic study finds

Researchers used genomic and Mendelian randomization analyses in over 500,000 individuals to reveal a statistically significant causal link between instant coffee intake and increased risk of dry age-related macular degeneration (AMD). No such risk was found for ground or decaffeinated coffee.

17 Jun 2025

Study reveals 15 hidden genetic risk factors for celiac disease

This comprehensive GWAS reveals 15 new genetic variants linked to celiac disease, offering insights for earlier detection and tailored treatment strategies.

9 Jun 2025

Mediterranean eating habits help European children fight genetic obesity risk

A large European cohort study found that adherence to the Mediterranean diet mitigates the impact of genetic risk for obesity in children, especially in early childhood. High consumption of vegetables and legumes was linked to lower obesity risk, regardless of genetic predisposition.

22 May 2025

Scientists link specific gene variants to post-vaccine myocarditis and pericarditis

A genome-wide association study in Sweden identified rare genetic variants near the SCAF11 and LRRC4C genes that may be linked to heart inflammation following COVID-19 mRNA vaccination. The findings shed light on potential biological pathways driving vaccine-associated myocarditis and pericarditis, particularly among younger individuals.

11 May 2025

Why your baby’s first steps may be written in their DNA

Researchers identified 11 genetic loci linked to the age at which infants start walking, revealing that this milestone is influenced by thousands of common genetic variants. These genetic factors also correlate with brain development, cognitive traits, and neurodevelopmental conditions like ADHD.

8 May 2025

Genetic test outperforms PSA and MRI in spotting deadly prostate cancer early

A UK study found that using a polygenic risk score to identify men at highest genetic risk of prostate cancer significantly improved detection of clinically important disease. This approach caught aggressive cancers that standard PSA and MRI screening would have missed.

10 Apr 2025

Higher BMI in adolescence worsens genetic risk for high blood pressure, study finds

Adolescent BMI amplifies genetic risk for high blood pressure, with sex-specific differences in how BMI modifies SBP susceptibility in adulthood.

17 Mar 2025

Researchers uncover 195 genetic risk factors driving women’s reproductive diseases

Scientists identified 195 genetic risk loci across 42 female reproductive health conditions, revealing shared genetic pathways and developing a polygenic risk score for intrahepatic cholestasis of pregnancy (ICP). These findings pave the way for personalized reproductive healthcare and targeted treatments based on genetic risk.

12 Mar 2025

Exploring the causal links among immune cells, inflammatory proteins, and aortic dissection

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Aortic dissection is a life-threatening condition with complex immunological underpinnings.

10 Mar 2025

How tobacco and cannabis affect male fertility and genetic integrity

A study reveals cannabis and tobacco use harm sperm quality and DNA integrity, with cannabis causing greater damage, raising concerns for reproductive health.

6 Mar 2025

Exploring the role of SNPs in early diagnosis of coronary microvascular dysfunction

A new review highlights the potential role of single nucleotide polymorphisms (SNPs) in improving the early diagnosis and targeted intervention of coronary microvascular dysfunction (CMD)—a condition linked to myocardial ischemia despite the absence of major artery blockages.

26 Feb 2025