immunity News and Research

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Long non-coding RNAs offer new pathways to overcome cancer treatment resistance

Scientists are highlighting long non-coding RNAs (lncRNAs) as promising targets in the effort to overcome one of cancer treatment's most persistent challenges: therapeutic resistance.

12 Oct 2026

RNA modification enzyme FTO shows therapeutic promise in gastrointestinal cancers

A new review in Genes & Diseases highlights FTO, an enzyme involved in RNA modification, as a potentially important biomarker and therapeutic target across gastrointestinal cancers.

12 Oct 2026

Review highlights EP4 receptor as target for inflammatory diseases

A review published in Genes & Diseases highlights the prostaglandin E2 receptor subtype 4 (EP4) as an important regulator of inflammation and a promising therapeutic target for a wide range of inflammatory and inflammation-related diseases.

12 Oct 2026

Targeting mitochondrial vulnerabilities could help treat triple-negative breast cancer

A deeper understanding of mitochondrial function could create new opportunities for treating triple-negative breast cancer (TNBC), one of the most aggressive and difficult-to-treat forms of breast cancer.

12 Oct 2026

Targeting lipophagy could help treat metabolic and oxidative stress-related diseases

A review published in Genes & Diseases highlights lipophagy, the cellular process that selectively breaks down lipid droplets, as a potentially important therapeutic target for conditions driven by disrupted lipid metabolism and oxidative stress.

12 Oct 2026

New review highlights expanding potential of therapeutic DNA vaccines

A new review published in Genes & Diseases highlights the expanding potential of DNA-based vaccines as a flexible platform for preventing infectious diseases, treating cancer and strengthening preparedness for future disease outbreaks.

12 Oct 2026

Nasal immune adjuvant protects mice against respiratory viruses for months

The COVID-19 pandemic showed the challenges of protecting populations when a new respiratory virus emerges.

9 Oct 2026

New immune aging map helps decode future chronic disease risks

While birthday candles measure the number of years someone has lived, they don't always tell the full story about someone's health.

9 Oct 2026

Polymeric nanomedicine strategies improve solid tumor immunotherapy outcomes

Solid tumors are not merely collections of malignant cells but complex ecosystems comprising tumor cells, stromal cells, and the extracellular matrix (ECM).

9 Oct 2026

Study explains why cancer immunity declines faster in males

Lutz Menzel, PhD, formerly of the Department of Radiation Oncology within the Mass General Brigham Cancer Institute, and Tim Padera, PhD, currently of the Mass General Brigham Cancer Institute, are the lead and senior authors of a paper published in Nature Aging, "Lymph node contraction links sex-biased naive CD8 T cell decline to compromised antigen recognition during middle age."

9 Oct 2026

Brain injuries change how the hypothalamus responds to stress

Researchers from the Department of Cell Biology, Genetics and Physiology at the University of Malaga have led an international scientific team that has studied how a traumatic brain injury caused by a severe blow to the head conditions the brain's long-term response to subsequent stress situations.

9 Oct 2026

New research unveils role of innate immune system in pancreatic cancer

Researchers from Adelaide University have demonstrated that blocking a specific immune system gene can reduce pancreatic cancer tumor formation.

9 Oct 2026

$13.1 million grant backs bacterial therapies for resistant breast cancer

A scientist at Weill Cornell Medicine is working with colleagues at the University of Massachusetts Amherst on new, complementary research efforts engineering therapeutic Salmonella to target critical gaps in treatment for drug-resistant triple-negative breast cancers.

9 Oct 2026

Certain gut bacteria may intensify inflammatory responses to vaccines

A person's microbiome may help determine whether they develop a fever after receiving a vaccination, according to a new study.

8 Oct 2026

Rare dendritic cells may promote immune tolerance in metastatic cancer

This study was co-led by Steven Blum, MD. Gary Reynolds, MD, PhD, Samuel Klempner, MD, and Alexandra-Chloé Villani, PhD, jointly supervised the work at the Krantz Family Center for Cancer Research within the Mass General Brigham Cancer Institute and the Mass General Brigham Center for Immunology & Inflammatory Diseases (CIID).

8 Oct 2026

Excess adiposity may alter the immune environment of airways to promote lung cancer

In a recent study of more than a thousand individuals, greater adiposity, or excessive body fat or fatty tissue, specifically in the abdomen, was associated with lung cancer.

8 Oct 2026

Vaccination protects the immune system from long-term infection damage

Vaccination not only prevents disease caused by acute infection but also protects against long-term immune-related sequelae that can follow an acute viral infection.

8 Oct 2026

Why is dengue spreading while malaria has declined?

Rising temperatures are reshaping malaria and dengue dynamics, revealing contrasting trends driven by urbanization, disease control, and socioeconomic factors.

8 Oct 2026

Short-term vaping exposure injures deep lung tissue and immunity

Just days of e-cigarette vapor exposure can injure the lungs' most delicate tissue and leave it more vulnerable to viral infection, according to a study led by National Jewish Health researchers and published in JCI Insight.

6 Oct 2026

Overweight dementia patients likely to live longer than normal weight peers

People who are overweight or obese when they are diagnosed with dementia are likely to live longer than those in a normal weight range, according to a new study by Columbia University Mailman School of Public Health and NYU School of Global Public Health.

6 Oct 2026