Alzheimer's Disease News and Research

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Alzheimer's disease (AD) is an irreversible, progressive brain disease that slowly destroys memory and thinking skills and, eventually, the ability to carry out the simplest tasks of daily living. In most people with AD, symptoms first appear after age 60. AD is the most common cause of dementia among older people, but it is not a normal part of aging. Dementia refers to a decline in cognitive function that interferes with daily life and activities. AD starts in a region of the brain that affects recent memory, then gradually spreads to other parts of the brain. Although treatment can slow the progression of AD and help manage its symptoms in some people, currently there is no cure for this devastating disease.

How the brain tracks distance in the dark without landmarks

Whether you are heading to bed or seeking a midnight snack, you don't need to turn on the lights to know where you are as you walk through your house at night.

17 Dec 2025

Severe weather exposure increases long-term mortality risk in older adults

Severe weather events have long-term health consequences for vulnerable older adults, according to a study in the Journal of the American Geriatrics Society based on data following Hurricane Harvey.

17 Dec 2025

Lysophosphatidylcholines show gene-dependent effects in early Alzheimer’s disease

A new study presents robust evidence on the role of lysophosphatidylcholines (LPCs) in the onset of Alzheimer's disease. Researchers discovered that LPCs-compounds that transport a variety of healthy fatty acids to the brain-either promote Alzheimer's or protect against it, depending on a person's genetics.

17 Dec 2025

Hyperphosphorylated tau may help protect the brain from infection

One of the main proteins that contributes to Alzheimer's disease is called phospho-tau (p-tau). When p-tau gets too many phosphate groups attached to it (a process called hyperphosphorylation), it starts to stick together and form clumps called "tangles" inside of brain nerve cells.

17 Dec 2025

Traumatic brain injury disrupts brain drainage and accelerates Alzheimer’s risk

University of Virginia School of Medicine researchers have uncovered how and why traumatic brain injury (TBI) increases the risk for Alzheimer's disease, and their work suggests a potential way to prevent that increased risk.

16 Dec 2025

Tau biology expands beyond microtubules to neurodegeneration, metabolism and mental illness

An Thought Leaders Invited Review published today in Genomic Psychiatry by Dr. Peng Lei and colleagues presents a sweeping synthesis of tau protein research that fundamentally reframes our understanding of this molecule's dual identity.

16 Dec 2025

New research highlights the importance of social engagement for cognitive health

New research from the University of St Andrews has discovered a direct causal effect between social isolation and a faster decline in later- life cognitive function. Pathological cognitive decline is most often driven by Alzheimer's and related dementias.

16 Dec 2025

New framework tracks response to anti-amyloid therapies in Alzheimer's

In the last few years, progress has been made in the fight against Alzheimer's disease with a class of therapies called anti-amyloid antibodies (anti-Aβ).

15 Dec 2025

New study defines rapidly progressive dementia

A new multicenter study led by Mayo Clinic researchers has established a practical, evidence-based definition for rapidly progressive dementia (RPD), a rare but devastating form of cognitive decline that develops over months instead of years.

15 Dec 2025

FAU researchers create deep learning model that detects and evaluates Alzheimer's, FTD

Dementia is a group of disorders that gradually impair memory, thinking and daily functioning. Alzheimer's disease (AD), the most common form of dementia, affects about 7.2 million Americans aged 65 and older in 2025.

15 Dec 2025

New molecular ruler enables precise measurement of toxic Tau fibrils in fluid samples

Researchers have developed a new tool, FibrilPaint combined with the FibrilRuler test, that allows scientists to directly measure the length of toxic Tau amyloid fibrils in tiny fluid samples, from the earliest aggregation stages to mature fibrils and even at very low concentrations.

11 Dec 2025

Researchers identify enzyme linked to myelin damage and neurodegenerative conditions

Researchers at Oregon Health & Science University have identified a type of enzyme with a complicated name - cell migration inducing and hyaluronan-binding protein, or CEMIP - is associated with disorders ranging from multiple sclerosis to stroke to neurodegenerative conditions like Alzheimer's disease.

11 Dec 2025

Analysis of Alzheimer's disease and related dementias uncovers disparities in Maryland's rural communities

A new statewide spatial analysis of Alzheimer's disease and related dementias (ADRD) has uncovered significant disparities in Maryland's rural communities, offering a striking example of how healthcare accessibility is shaping health outcomes across the United States.

10 Dec 2025

Online reference library provides a more accurate picture of drug exposure

Doctors and researchers try to understand what medications a person has taken by asking patients directly or by looking at medical records. But this information is often incomplete.

9 Dec 2025

UCI MIND secures major funding for new Alzheimer's research facility

With a $50 million lead gift from the Quilter family and approximately $30 million in new commitments, the University of California, Irvine's Institute for Memory Impairments and Neurological Disorders will begin planning to build a state-of-the-art research and care facility to enhance its position as a global leader in Alzheimer's disease and related dementias research and patient care.

8 Dec 2025

Study provides first molecular evidence that ferroptosis can drive neurodegeneration

Researchers at Helmholtz Munich, the Technical University of Munich and the LMU University Hospital Munich uncovered a mechanism that protects nerve cells from premature cell death, known as ferroptosis.

4 Dec 2025

Poor kidney function associated with elevated Alzheimer’s markers in the blood

People with impaired kidney function have higher levels of Alzheimer's biomarkers in their blood, but not an increased risk of dementia, according to a study published December 3, 2025, in Neurology®, the medical journal of the American Academy of Neurology.

3 Dec 2025

Hidden cellular layers in the hippocampus' CA1 region revealed

Researchers at the Mark and Mary Stevens Neuroimaging and Informatics Institute (Stevens INI) at the Keck School of Medicine of USC have identified a previously unknown pattern of organization in one of the brain's most important areas for learning and memory.

3 Dec 2025

Alzheimer's disease blood biomarkers increase up to 95% faster in obese individuals

Researchers have conducted the first study evaluating the impact of obesity on Alzheimer's disease blood biomarkers (BBMs).

2 Dec 2025

Most of the world falls short on omega-3 intake

More than three-quarters of the global population aren't getting enough Omega-3, according to new research from the University of East Anglia, the University of Southampton and Holland & Barrett.

1 Dec 2025

Alzheimer's Disease News and Research

Further Reading

How the brain tracks distance in the dark without landmarks

Severe weather exposure increases long-term mortality risk in older adults

Lysophosphatidylcholines show gene-dependent effects in early Alzheimer’s disease

Hyperphosphorylated tau may help protect the brain from infection

Traumatic brain injury disrupts brain drainage and accelerates Alzheimer’s risk

Tau biology expands beyond microtubules to neurodegeneration, metabolism and mental illness

New research highlights the importance of social engagement for cognitive health

New framework tracks response to anti-amyloid therapies in Alzheimer's

New study defines rapidly progressive dementia

FAU researchers create deep learning model that detects and evaluates Alzheimer's, FTD

New molecular ruler enables precise measurement of toxic Tau fibrils in fluid samples

Researchers identify enzyme linked to myelin damage and neurodegenerative conditions

Analysis of Alzheimer's disease and related dementias uncovers disparities in Maryland's rural communities

Online reference library provides a more accurate picture of drug exposure

UCI MIND secures major funding for new Alzheimer's research facility

Study provides first molecular evidence that ferroptosis can drive neurodegeneration

Poor kidney function associated with elevated Alzheimer’s markers in the blood

Hidden cellular layers in the hippocampus' CA1 region revealed

Alzheimer's disease blood biomarkers increase up to 95% faster in obese individuals

Most of the world falls short on omega-3 intake

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