Liver Disease News and Research

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The liver is one of the largest solid organs of the body. It is located in the upper right part of the abdomen. Most of the organ lies under cover of the rib cage.

Existing drug could prevent liver damage caused by ammonia build-up

High levels of ammonia kill liver cells by damaging the mitochondria that power the cells. But this can be prevented using an existing drug due to start clinical trials, finds a new study in mice led by researchers from UCL.

7 Mar 2025

Asah1 gene plays key role in preventing progression of nonalcoholic fatty liver disease

Investigators have found that the gene Asah1 plays a crucial protective role in preventing the progression of nonalcoholic fatty liver diseases (NAFLD) into more severe forms of liver disease by regulating hepatic lipid homeostasis and cellular maintenance processes.

6 Mar 2025

Breakthrough study defines ideal interval for immunotherapy and liver transplants

Hepatocellular carcinoma (HCC) represents about 80 to 90% of cases of primary liver cancer. On a global level, 905,700 new cases and 830,200 deaths were registered in 2020 according to the World Health Organization.

6 Mar 2025

New drug candidate may help combat metabolic dysfunction-associated steatotic liver disease

A study published in Nature Aging has revealed a promising new drug candidate that may help combat metabolic dysfunction-associated steatotic liver disease (MASLD), a chronic liver condition that disproportionately affects communities in San Antonio due to high rates of obesity and diabetes.

5 Mar 2025

Breakthrough research uncovers way to maintain metabolism during calorie restriction

Many people who have tried to lose weight by cutting calories are familiar with this frustrating reality: at some point, the body stops shedding pounds.

3 Mar 2025

Review sheds light on the mechanistic role of long non-coding RNAs in liver disease

Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD), is a global health challenge, affecting nearly 30% of adults worldwide.

28 Feb 2025

Understanding the impact of SLC transporters on liver disease progression

Hepatic steatosis, often triggered by non-alcoholic fatty liver disease (NAFLD), is a leading cause of liver dysfunction globally, affecting approximately 30% of the population.

28 Feb 2025

Study unravels the link between colorectal cancer risk and steatotic liver disease

Alcoholic and non-alcoholic fatty liver disease (NAFLD) are well-known risk factors for colorectal cancer (CRC).

27 Feb 2025

Microphysiological systems in drug discovery

NewsMedical speaks with CN Bio about the translatability between in vitro organ-on-a-chip (OOC) models, microphysiological systems, and their in vivo counterparts.

From CN Bio 26 Feb 2025

Insilico Medicine reaches preclinical milestone in MASH drug discovery

Insilico Medicine("Insilico"), a clinical-stage generative artificial intelligence (AI)-driven drug discovery company, recently achieved preclinical milestone in its collaboration with Therasid Bioscience, a South Korean based biotechnology company focuses on developing innovative first-in-class drugs for treatment for metabolic dysfunction-associated steatohepatitis (MASH).

25 Feb 2025

Exploring the link between cholestasis and depression

Announcing a new publication for Acta Materia Medica journal. The prevalence of depressive-like behavior is significantly higher in patients with cholestatic liver disease, leading to a notable reduction in the quality of life.

23 Feb 2025

Vitamin E significantly improves liver health in MASH patients, new study finds

A 96-week clinical trial found that 300 mg of Vitamin E significantly improved liver histology and reduced inflammation in patients with MASH, with no major safety concerns reported.

19 Feb 2025

Low-dose semaglutide reduces alcohol consumption and cravings in early trial

Research reveals semaglutide's effectiveness in decreasing alcohol consumption and cravings, highlighting its potential for treating alcohol use disorder.

13 Feb 2025

Study finds varying cardiovascular risks associated with different hormonal contraceptives

Certain hormonal contraceptives are associated with a higher stroke and heart attack risk, finds a large study from Denmark in The BMJ today that draws on prescription records to give more precise estimates for different products than previous studies.

13 Feb 2025

Study connects loneliness and social isolation to non-alcoholic fatty liver disease risk

Loneliness and social isolation have been linked to an elevated risk of non-alcoholic fatty liver disease (NAFLD), according to a groundbreaking study conducted by researchers from Central South University and the Army Medical University in China, in collaboration with the Karolinska Institutet in Sweden.

12 Feb 2025

Could a common sugar in processed foods be fueling childhood liver disease?

Researchers found that high fructose intake, especially from processed foods, is linked to metabolic dysfunction-associated steatotic liver disease (MASLD) in children with obesity, with potential misreporting of sugary food sources.

12 Feb 2025

Blockbuster drug for diabetes and obesity could also help reduce alcohol intake

The blockbuster drug semaglutide, better known as Ozempic for diabetes and Wegovy for obesity, could also help people cut down on their alcohol intake, according to new USC research.

12 Feb 2025

PDZK1's role in estrogen-induced cholestasis unveiled

Announcing a new publication for Acta Materia Medica journal. Estrogens have been reported to cause dysfunction in biliary transport systems, thereby inducing cholestasis. Multidrug resistance-associated protein 2 (MRP2) is a transporter responsible for independent bile flow.

11 Feb 2025

Vancomycin could offer new therapeutic option for patients with a type of inflammatory bowel disease

An antibiotic used to treat infective diarrhoea could be an effective drug for a type of inflammatory bowel disease, a new study has found.

10 Feb 2025

Liver graft preservation methods alter microbiota composition after transplantation

End-stage liver disease is associated with disruptions in gut microbiota composition and function, which may facilitate gut-to-liver bacterial translocation, impacting liver graft integrity and clinical outcomes following liver transplantation.

7 Feb 2025

Liver Disease News and Research

Further Reading

Existing drug could prevent liver damage caused by ammonia build-up

Asah1 gene plays key role in preventing progression of nonalcoholic fatty liver disease

Breakthrough study defines ideal interval for immunotherapy and liver transplants

New drug candidate may help combat metabolic dysfunction-associated steatotic liver disease

Breakthrough research uncovers way to maintain metabolism during calorie restriction

Review sheds light on the mechanistic role of long non-coding RNAs in liver disease

Understanding the impact of SLC transporters on liver disease progression

Study unravels the link between colorectal cancer risk and steatotic liver disease

Microphysiological systems in drug discovery

Insilico Medicine reaches preclinical milestone in MASH drug discovery

Exploring the link between cholestasis and depression

Vitamin E significantly improves liver health in MASH patients, new study finds

Low-dose semaglutide reduces alcohol consumption and cravings in early trial

Study finds varying cardiovascular risks associated with different hormonal contraceptives

Study connects loneliness and social isolation to non-alcoholic fatty liver disease risk

Could a common sugar in processed foods be fueling childhood liver disease?

Blockbuster drug for diabetes and obesity could also help reduce alcohol intake

PDZK1's role in estrogen-induced cholestasis unveiled

Vancomycin could offer new therapeutic option for patients with a type of inflammatory bowel disease

Liver graft preservation methods alter microbiota composition after transplantation

Industry Focus eBook - Analytical Chemistry (2nd Edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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