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Investigational oral therapy shows safety and potential benefits in ALS trial

In a phase 2b clinical trial, an investigational oral therapy called PrimeC was found to be safe and well tolerated in people living with amyotrophic lateral sclerosis (ALS), with exploratory findings suggesting target engagement and potential clinical benefits.

16 Mar 2026

New BrainGate iBCI typing neuroprosthesis can restore communication in patients with paralysis

Loss of communication can be among the most devastating symptoms for patients with paralysis. A new study by investigators from Mass General Brigham Neuroscience Institute and Brown University describes an investigational implantable brain computer interface (iBCI) typing neuroprosthesis that can restore communication with speed and accuracy.

16 Mar 2026

Study suggests new way to diagnose combined Alzheimer’s and FTLD

People with Alzheimer's disease often have other neurodegenerative conditions as well, including a less-understood disorder called frontotemporal lobar degeneration (FTLD).

16 Mar 2026

New polygenic risk scores improve prediction of metabolic disease outcomes

Type 2 diabetes (T2D) and obesity are metabolic conditions with many causes, including overlapping and distinct genetic features.

16 Mar 2026

Circular RNA produced by HIV boosts viral replication

For decades scientists have recognized that human immunodeficiency virus (HIV) is a formidable viral pathogen.

13 Mar 2026

Using machine learning to identify individuals at risk for intimate partner violence

Researchers at Mass General Brigham have developed a series of artificial intelligence (AI) tools that uses machine learning to identify individuals who may be at risk for intimate partner violence (IPV) using information from their electronic medical records (EMRs).

13 Mar 2026

Doctors warn of a deadly complication from measles outbreaks

The first sign came when Deepanwita Dasgupta was 5 and started stumbling more while playing at her home in Bangalore in southern India.

13 Mar 2026

ISSCR launches education program on stem cell treatments for Parkinson's

The International Society for Stem Cell Research (ISSCR) today announced the launch of Stem Cell Medicine: Parkinson's Disease, a new continuing education course designed to equip clinicians with an evidence-based understanding of emerging stem cell therapies for Parkinson's disease (PD).

12 Mar 2026

Experimental therapy eliminates pancreatic precancerous cells in mice study

A new preclinical study in mice shows that precancerous cells in the pancreas can be eliminated before they have the chance to become tumors.

12 Mar 2026

Romiplostim prevents chemotherapy-induced thrombocytopenia in phase 3 trial

Results from a global phase 3 clinical trial led by investigators at Mass General Brigham show that the medication romiplostim can effectively prevent chemotherapy from destroying platelet-producing bone marrow cells, a common complication known as chemotherapy-induced thrombocytopenia.

12 Mar 2026

Study finds treatment gap for young ADHD patients with substance use disorders

Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder, affecting 12%–13% of adolescents in the United States, according to some studies.

12 Mar 2026

High-dose vitamin D3 does not reduce COVID-19 severity, but may impact long COVID outcomes

In a large, randomized trial, researchers at Mass General Brigham have found that high-dose vitamin D3 did not reduce COVID-19 infection severity, but may impact long COVID outcomes.

12 Mar 2026

Immune switch plays a critical role in successful pregnancies

Early pregnancy depends on a remarkable act of coordination. Before the placenta can nourish a growing fetus, the embryo must securely "land" and connect with the mother's blood supply - a process guided by a specialized group of immune cells called uterine natural killer cells, or uNK cells.

12 Mar 2026

Study links prior authorization to delayed heart failure prescriptions

Prior authorization, a process that requires physicians to obtain approval from health care insurers before certain treatments are covered, may keep patients from filling prescriptions for two critical heart failure drugs, a new study shows.

12 Mar 2026

Marburg virus enters human cells far more efficiently than Ebola

In a new study published in Nature, University of Minnesota researchers found that the Marburg virus, one of the world's deadliest pathogens with an average 73% fatality rate, is unusually efficient at getting inside human cells.

11 Mar 2026

DNA origami vaccine platform shows promise against multiple infectious viruses

The COVID-19 pandemic brought messenger RNA (mRNA) vaccines to the forefront of global health care. After their clinical trial stages, the first COVID-19 mRNA vaccine was administered on 8 December 2020 and mathematical models suggest that mRNA vaccines prevented at least 14.4 million deaths from COVID-19 in the first year alone.

11 Mar 2026

Multi-agent AI systems outperform single models under heavy clinical workloads

As artificial intelligence (AI) becomes more common in health care, from managing records to assisting with medication decisions, researchers at the Icahn School of Medicine at Mount Sinai are asking an important question: How well does AI hold up when the workload gets intense at health system scale?

10 Mar 2026