Neurodegenerative Diseases News and Research

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UIC scientists find new way to better target cellular proteins

By studying how enzymes move from one membrane compartment to another inside a cell, scientists at the University of Illinois Chicago have figured out a way to better target cellular proteins, which play a role in many diseases.

15 Feb 2023

Centrosome regulates nerve cell migration, study finds

Researchers from the DZNE have solved an important puzzle in neurobiology: the wiring and the movement of nerve cells are interwoven, but separately controlled.

15 Feb 2023

Researchers identify a novel mechanism of DNA repair that occurs in neurons

"Use it or lose it" goes the adage, applied liberally to everything from our muscles to our minds, especially as we age.

15 Feb 2023

Electrochemical method helps to continuously witness and analyze details of protein folding

Scientists are not yet clear on how the tau protein changes from a benign protein essential for normal function in our brains into the toxic neurofibrillary tangles that are a signature of Alzheimer's and other neurodegenerative diseases.

15 Feb 2023

Is gut microbiome lipid metabolism a determinant of human health?

Researchers highlighted the role of lipids, especially bacteria-derived lipids in the gut microbiome, in mammalian physiology in the context of immunity and metabolism. Note that commensal fungal species also produce lipid metabolites.

10 Feb 2023

Novel nuclear medicine imaging protocol cuts costs and radiation exposure for Alzheimer's patients

A novel nuclear medicine imaging protocol can take the place of two separate imaging scans for the evaluation of brain changes linked to cognitive impairment, cutting costs and radiation exposure for patients as well as providing them greater comfort.

8 Feb 2023

Study reveals some of the fundamental biology of p97 protein in neurodegenerative disease

The p97 protein is one of your body's best garbage disposers. It floats around in your cells looking for signals that a protein is past its shelf life and needs to be trashed.

7 Feb 2023

Cryo-EM reveals the structure of hnRNPDL-2 protein fibrils associated with limb-girdle muscular dystrophy

Limb-girdle muscular dystrophy type 3 (LGMD D3) is a rare disease causing progressive muscle weakness, caused by point mutations in the hnRNPDL-2 protein.

3 Feb 2023

Study offers clues about the biology of cells in the spinal cord that die off in ALS

New research offers clues about the biology of cells in the spinal cord that die off in amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases.

2 Feb 2023

Microscopic technique enables real-time study of RNA G-quadruplexes in living cells

A new microscopic technique allows for the real-time study of RNA G-quadruplexes in living cells, with implications for the fight against amyotrophic lateral sclerosis.

2 Feb 2023

U of A researcher one step closer to demonstrating the potential of brain molecule to halt MS

A University of Alberta researcher is one step closer to demonstrating the potential of a brain molecule called fractalkine to halt and even reverse the effects of multiple sclerosis and other neurodegenerative diseases.

1 Feb 2023

Focused-ultrasound-mediated liquid biopsy improves detection of neurodegeneration biomarkers

Several progressive neurodegenerative disorders, including Alzheimer's disease, are defined by having tau proteins in the brain.

31 Jan 2023

New discovery about microglia heralds myriad possibilities for treating neurodegenerative diseases

Combating Alzheimer's and other neurodegenerative diseases by inserting healthy new immune cells into the brain has taken a leap toward reality.

30 Jan 2023

Special vascular cells sense when the brain region needs energy

When we smell hot dogs, it may trigger memories of backyard barbeques or attending baseball games during childhood.

26 Jan 2023

Study explores how different clusters of cardiometabolic conditions increase dementia risk in older adults

People in the United States and England who have multiple cardiometabolic conditions such as diabetes and high systolic blood pressure are more likely to develop dementia than their peers who are relatively healthy, according to new research from the University of Surrey.

24 Jan 2023

Study reveals sex differences in response to drugs targeting tauopathies

Microglia are cells that are central to both brain health as well as disease progression in many neurological conditions.

24 Jan 2023

Epidemiological evidence that Alzheimer's and Parkinson's could be caused by viral infections

A recent study published in the journal Neuron has focussed on assessing the putative associations between viral exposures and neurodegenerative disease (NDD) onset, using real-world biobank scale data.

23 Jan 2023

All-cause mortality risk higher among individuals with head injury

Adults who suffered any head injury during a 30-year study period had two times the rate of mortality than those who did not have any head injury, and mortality rates among those with moderate or severe head injuries were nearly three times higher, according to new research from the Perelman School of Medicine at the University of Pennsylvania, published today in JAMA Neurology.

23 Jan 2023

Ubiquigent collaborates with University of Glasgow on translational structural biology to accelerate drug discovery within the (de)ubiquitylation field

Ubiquigent Limited (Ubiquigent), a drug discovery and development company harnessing novel deubiquitinase (DUB) modulators as new therapeutics for areas of high unmet medical need, today announced it is supporting a Master’s student at the University of Glasgow (UoG) to undertake a research project on USP30, a DUB implicated in neurodegenerative, renal, and cardiovascular diseases.

From Ubiquigent Limited 23 Jan 2023

Novel prion strain causes chronic wasting disease in a Finland moose

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19 Jan 2023

Neurodegenerative Diseases News and Research

UIC scientists find new way to better target cellular proteins

Centrosome regulates nerve cell migration, study finds

Researchers identify a novel mechanism of DNA repair that occurs in neurons

Electrochemical method helps to continuously witness and analyze details of protein folding

Is gut microbiome lipid metabolism a determinant of human health?

Novel nuclear medicine imaging protocol cuts costs and radiation exposure for Alzheimer's patients

Study reveals some of the fundamental biology of p97 protein in neurodegenerative disease

Cryo-EM reveals the structure of hnRNPDL-2 protein fibrils associated with limb-girdle muscular dystrophy

Study offers clues about the biology of cells in the spinal cord that die off in ALS

Microscopic technique enables real-time study of RNA G-quadruplexes in living cells

U of A researcher one step closer to demonstrating the potential of brain molecule to halt MS

Focused-ultrasound-mediated liquid biopsy improves detection of neurodegeneration biomarkers

New discovery about microglia heralds myriad possibilities for treating neurodegenerative diseases

Special vascular cells sense when the brain region needs energy

Study explores how different clusters of cardiometabolic conditions increase dementia risk in older adults

Study reveals sex differences in response to drugs targeting tauopathies

Epidemiological evidence that Alzheimer's and Parkinson's could be caused by viral infections

All-cause mortality risk higher among individuals with head injury

Ubiquigent collaborates with University of Glasgow on translational structural biology to accelerate drug discovery within the (de)ubiquitylation field

Novel prion strain causes chronic wasting disease in a Finland moose

Why use light scattering to analyze proteins and viral vectors?

Changing the landscape of R&D to build clinical success from the ground up

Sensing a Healthier Future

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