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Light-Seq technology for barcoding and deep-sequencing selected cell populations in tissues

Under the microscope, researchers often observe different cell types organizing themselves in peculiar patterns within tissues, or sometimes a rare cell type that stands out by occupying a unique position, exhibiting an unusual shape, or expressing a specific biomarker molecule.

10 Oct 2022

RNA-dependent RNA polymerase inhibitors in COVID-19 therapy

A new paper reviews current knowledge of RdRp inhibitors that could be developed further to provide broadly effective antivirals against SARS-CoV-2 in particular and CoVs in general.

10 Oct 2022

Zinc could improve the brain defects caused by rare genetic disorder

Pediatric encephalopathies of genetic origin cause severe motor and intellectual disabilities from birth. One of these diseases, first identified in 2013, is caused by mutations in the GNAO1 gene.

10 Oct 2022

NEI researchers create a high-resolution map of retinal cell chromatin contract points

National Eye Institute researchers mapped the organization of human retinal cell chromatin, the fibers that package 3 billion nucleotide-long DNA molecules into compact structures that fit into chromosomes within each cell's nucleus.

7 Oct 2022

Research identifies new clue for preventing and treating gliomas

An important new clue for preventing and treating brain tumors known as gliomas has been identified in research led by the Lunenfeld-Tannenbaum Research Institute (LTRI) at Mount Sinai Hospital in Toronto and Mayo Clinic Comprehensive Cancer Center and Mayo Clinic Center for Individualized Medicine.

7 Oct 2022

Study attributes increased transmissibility of Monkeypox Clade IIb to genomic accordions

In a new study, researchers performed a genomic study of confirmed Monkeypox virus (MPXV) cases diagnosed in Spain between 18 May and 14 July 2022.

4 Oct 2022

What are the genetic associations of stroke pathogenesis across ancestry groups?

In new research, researchers identified genetic associations of stroke pathogenesis.

4 Oct 2022

Structural analysis of monkeypox virus to guide the development of broad antiviral agents

In a new study, researchers explored the crystalline structure of the monkeypox (MPX) virus (MPXV) and the complex of VP39, a 2′-O-RNA methyltransferase (MTase) and sinefungin, a pan-MTase inhibitor.

30 Sep 2022

DNA metagenomic analyses of clinical samples from Monkeypox virus-infected individuals

Researchers analyzed genomic sequences of MPXV obtained from 18 patients who contracted MPXV infection between June and July 2022.

30 Sep 2022

Study finds dimethyl fumarate was not associated with an improvement in clinical outcomes in adults hospitalized with COVID-19

Researchers evaluated the efficacy of the anti-inflammatory drug dimethyl fumarate in treating COVID-19 as part of an early phase, randomized, controlled assessment trial in the UK.

28 Sep 2022

Researchers uncover a new way the immune system detects coronavirus infection

In a recent study posted to bioRxiv*, researchers in the United States demonstrated that the main protease (Mpro) of coronaviruses (CoVs) activates host inflammasome responses.

27 Sep 2022

Advanced software tool uncovers new cancer-driving genes

An advanced software tool for analyzing DNA sequences from tumor samples has uncovered likely new cancer-driving genes, in a study led by Weill Cornell Medicine researchers.

26 Sep 2022

Omicron BA.1 breakthrough infection in vaccinated individuals recall memory B cells to confer immunity

In a new study, researchers followed up with individuals vaccinated with a COVID-19 vaccine based on the mRNA platform up to six months following Omicron BA.1 breakthrough infection to trace the evolution of their antibody immunity.

26 Sep 2022

How smallpox and monkeypox viruses affect the nervous system

A recent study provides an overview of existing literature on the complications of infection with both smallpox and monkeypox virus.

25 Sep 2022

AI-guided tools pinpoint immune cell driver and protective genetic factor for esophageal cancer

Esophageal adenocarcinoma (EAC) is a type of cancer affecting the mucus-secreting glands of the lower esophagus -; the tube connecting the throat to the stomach.

22 Sep 2022

New antiviral mechanism of action for an FDA-approved thiopurine known as 6-thioguanine

Researchers described a novel antiviral mechanism of action for an FDA (food and drug administration)-approved thiopurine known as 6-thioguanine (6-TG).

21 Sep 2022

Evidence A.2 lineage of monkeypox is mutating

In a recent study posted to the bioRxiv* preprint server, a team of researchers from India analyzed the whole genome sequences of the monkeypox virus isolated from monkeypox patients with and without international travel histories to understand the phylogenetic relations and genomic evolution of the virus that could contribute to higher transmission rates.

21 Sep 2022

O-linked sialoglycans affect SARS-CoV-2 spike cleavage

In a recent study posted to the bioRxiv* preprint server, researchers from Spain, the United Kingdom, and the United States used chemical tools to uncover the molecular details of glycan-mediated modulation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) processing.

19 Sep 2022

Environmental surveillance detects poliovirus type 2 outbreaks in Israel

The wastewater environmental surveillance conducted in Jerusalem, Israel, has detected an increasing population of poliovirus type 2. Furthermore, these viral isolates are associated with vaccine-derived viral strains.

19 Sep 2022

Crested ibis offers clues that could help our bodies to make better drugs

Thank the rare crested ibis for a clue that could someday help our bodies make better drugs.

19 Sep 2022

Nucleotide News and Research

Light-Seq technology for barcoding and deep-sequencing selected cell populations in tissues

RNA-dependent RNA polymerase inhibitors in COVID-19 therapy

Zinc could improve the brain defects caused by rare genetic disorder

NEI researchers create a high-resolution map of retinal cell chromatin contract points

Research identifies new clue for preventing and treating gliomas

Study attributes increased transmissibility of Monkeypox Clade IIb to genomic accordions

What are the genetic associations of stroke pathogenesis across ancestry groups?

Structural analysis of monkeypox virus to guide the development of broad antiviral agents

DNA metagenomic analyses of clinical samples from Monkeypox virus-infected individuals

Study finds dimethyl fumarate was not associated with an improvement in clinical outcomes in adults hospitalized with COVID-19

Researchers uncover a new way the immune system detects coronavirus infection

Advanced software tool uncovers new cancer-driving genes

Omicron BA.1 breakthrough infection in vaccinated individuals recall memory B cells to confer immunity

How smallpox and monkeypox viruses affect the nervous system

AI-guided tools pinpoint immune cell driver and protective genetic factor for esophageal cancer

New antiviral mechanism of action for an FDA-approved thiopurine known as 6-thioguanine

Evidence A.2 lineage of monkeypox is mutating

O-linked sialoglycans affect SARS-CoV-2 spike cleavage

Environmental surveillance detects poliovirus type 2 outbreaks in Israel

Crested ibis offers clues that could help our bodies to make better drugs

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