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World's first confirmed case of SARS-CoV-2 re-infection

A team of researchers at the University of Hong Kong said that they have proven that a 33-year-old man was infected by the SARS-CoV-2 virus for a second time. The man was discharged from a hospital in April but contracted the infection again after returning from Spain via the United Kingdom in August.

24 Aug 2020

Single dose nasal vaccine against SARS-CoV-2 shows promise in animal studies

Now researchers at the Washington University School of Medicine in St. Louis have worked on developing a candidate vaccine against the infection that could be administered in a single dose via a nasal spray rather than an injection. In their preliminary studies using lab mice, this single dose of the nasal vaccine successfully prevented the infection with the novel coronavirus.

24 Aug 2020

Adaptions to aging may be impacted by genetic background

How we adapt to aging late in life may be genetically influenced, according to a study led by a psychologist at the University of California, Riverside.

19 Aug 2020

Deciphering the largest CRISPR system

Professor Guillermo Montoya spoke to News-Medical on his research that involved visualizing the largest and most complex CRISPR system.

17 Aug 2020

DHODH inhibitor PTC299 shows potential as a COVID-19 therapeutic

As COVID-19 continues to take a heavy toll on human health and life in many parts of the world, there is still no effective antiviral drug or vaccine. This has fueled an intensive search for small molecules and proteins that can inhibit viral entry and replication.

10 Aug 2020

Study: ANGEL2 enzyme performs unique chemical reaction at the end of RNA molecules

Scientists led by Javier Martinez from the Max Perutz Labs, a joint venture of the Medical University of Vienna and the University of Vienna, have identified a unique chemical reaction at the end of RNA molecules for the first time in human cells.

31 Jul 2020

Saccharibacteria within a mammalian host are more diverse than ever anticipated, shows study

Inside your mouth right now, there is a group of bacteria whose closest relatives can also be found in the belly of a moose, in dogs, cats, and dolphins, and in groundwater deep under the Earth's surface.

22 Jul 2020

Rapid genomic surveillance of healthcare-associated SARS-CoV-2

The researchers from the University of Cambridge, Cambridge United Kingdom have published their findings in a study titled, “Rapid implementation of SARS-CoV-2 sequencing to investigate cases of healthcare-associated COVID-19: a prospective genomic surveillance study,” in the latest issue of The Lancet Infectious Diseases.

16 Jul 2020

Researchers develop novel tool to maximize the power of deep learning for genomic studies

Researchers from the MDC have developed a new tool that makes it easier to maximize the power of deep learning for studying genomics.

13 Jul 2020

Researchers map RNA structure throughout SARS-CoV-2 genome

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which is currently at the heart of a pandemic that has cost the world more than 550,000 lives, 12 million infections, and uncounted years of productivity, is an RNA virus with the largest genome among all such viruses. This 30 kb size virus has caused many difficulties for scientists in search of a vaccine.

9 Jul 2020

CityU develops CRISPR-assisted method to identify RNA-binding proteins in living cells

While scientists still don't fully understand the diverse nature of RNA molecules, it is believed that the proteins binding to them, called RNA-binding proteins, are associated with many disease formation.

1 Jul 2020

Phosphorylation of SARS-CoV-2 N protein affects its function

Now, a new study by researchers at the University of California San Francisco and published on the preprint server bioRxiv* in June 2020 shows the effect of phosphorylation on the state and function of the N protein.

1 Jul 2020

New approach holds incredible potential for developing new therapeutics

Nearly every drug that is, or has ever been, used was derived from nature -- harnessing compounds created by organisms over eons to fight diseases. But decades ago, biochemists postulated that it might be possible to design a new drug from scratch by linking up amino acids in precise ways.

30 Jun 2020

New technique helps measure dNTP concentrations with greater sensitivity

A highly sensitive and easy-to-use technique applicable for tissue samples can be useful, for example, to researchers specialised in mitochondrial diseases and cancer.

24 Jun 2020

Organoids can help provide new level of accuracy in prescribing anti-cancer therapies

Precision medicine, using the power of the human genome to diagnose and treat patients, is about to get even more precise.

22 Jun 2020

Chimeric reference standards for validating controls in SARS-CoV-2 tests

A preliminary study by researchers from the Garvan Institute of Medical Research and the University of New South Wales and published on the preprint server bioRxiv in June 2020 reports the use of chimeric design to produced reference standards for diagnostic tests. This could allow a highly flexible approach to the development of different genetic features in the same test, even for organisms that are not directly related.

15 Jun 2020

MGH researchers identify key mechanism in X chromosome inactivation

Researchers at Massachusetts General Hospital have identified a key mechanism in X chromosome inactivation, a phenomenon that may hold clues that lead to treatments for certain rare congenital disorders.

12 Jun 2020

Ashion Analytics is now part of NCI's MATCH cancer clinical trials

Ashion Analytics, a clinical laboratory of the Translational Genomics Research Institute (TGen), an affiliate of City of Hope, is now part of the National Cancer Institute's MATCH program, which provides patients who have rare or difficult-to-treat cancers with access to unique clinical trials nationwide that might give them the best therapeutic treatments and outcomes.

12 Jun 2020

Scientists aim to develop a gene-targeting, antiviral agent against COVID-19

A team of scientists from Stanford University is working with researchers at the Molecular Foundry, a nanoscience user facility located at the Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab), to develop a gene-targeting, antiviral agent against COVID-19.

4 Jun 2020

Study reveals biochemical alterations in patients with Lesch-Nyhan disease

An international study by the Institute of Neuroscience of the UAB, Emory University and Hospital Universitario La Paz, published in the PNAS journal, shows that patients suffering from Lesch-Nyhan, a rare neurological disease, present biochemical alterations in skin cells (fibroblasts), urine and cerebrospinal fluid.

4 Jun 2020