Sclerosis News and Research

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Immune cell signatures explain variations in systemic sclerosis severity

Treating rare diseases can be complicated at the best of times, and it gets even more complicated when different patients with the same disease exhibit different symptoms.

18 Jun 2025

New molecular atlas offers unprecedented insight into human kidney function

The kidney, a critical organ for waste filtration and fluid regulation, is the subject of a groundbreaking molecular mapping project that could reshape our understanding of renal health.

18 Jun 2025

Living near algal blooms linked to faster ALS progression

Living close to cyanobacterial harmful algal blooms - which are present nationwide but are more common in coastal and Great Lake states - heightens the rate of dying from amyotrophic lateral sclerosis, or ALS, a study suggests.

17 Jun 2025

Mitochondrial dysfunction drives cerebellar damage in multiple sclerosis

Multiple sclerosis (MS) affects an estimated 2.3 million people worldwide. Approximately 80% of people with MS have inflammation in the cerebellum, the part of the brain that helps control movement and balance, potentially leading to tremors, poor coordination, and trouble with motor control.

16 Jun 2025

Deep B cell depletion offers new hope for rheumatologic and musculoskeletal diseases

CD19-CAR T-cell treatment is a novel option of deep B cell depletion with promising results across different rheumatologic and musculoskeletal diseases (RMD).

15 Jun 2025

Exercise therapy shows long-term benefits for people with rheumatic diseases

Regular physical activity is increasingly promoted for people with rheumatic and musculoskeletal diseases (RMD) as well as the general population.

13 Jun 2025

Early clinical events predict disease progression in very early systemic sclerosis

The VEDOSS project has previously shown that 70% of patients with Raynaud's phenomenon and at least one red flag – systemic sclerosis (SSc)-specific antibodies, puffy fingers, or an SSc pattern on nailfold capillaroscopy –will fulfil the 2013 ACR/EULAR SSc criteria within 5 years.

13 Jun 2025

Global differences shape how doctors approach ALS ventilation decisions

A new study reveals striking international differences in how doctors approach the sensitive issue of tracheostomy invasive ventilation (TIV) for patients with amyotrophic lateral sclerosis (ALS).

12 Jun 2025

Healthy lifestyle habits may shield aging cells from brain disorders

Stroke and dementia as well as late-life depression are more common in people who have a biomarker of aging called short leukocyte telomere length, according to a study published on June 11, 2025, online in Neurology, the medical journal of the American Academy of Neurology.

11 Jun 2025

Brain interface restores real-time speech for man with ALS

Researchers at the University of California, Davis, have developed an investigational brain-computer interface that holds promise for restoring the voices of people who have lost the ability to speak due to neurological conditions.

11 Jun 2025

Using causal machine learning to identify potential ALS treatments

Potential treatments for amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases may already be out there in the form of drugs prescribed for other conditions.

10 Jun 2025

Accelerated biological aging found in children with multiple sclerosis

Researchers from University of California San Diego School of Medicine have discovered that children living with multiple sclerosis (MS) show signs of accelerated biological aging, even in their teenage years.

9 Jun 2025

Scientists identify genetic clues linking air pollution to neurodegeneration

This review highlights how air pollution and occupational inhalation exposures may contribute to neurodegenerative disorders by triggering epigenetic changes. The authors stress the urgent need for advanced research to identify early biomarkers and guide protective health strategies for high-risk populations.

6 Jun 2025

Alzheimer's gene therapy could help protect the brain from damage and preserve cognitive function

Researchers at University of California San Diego School of Medicine have developed a gene therapy for Alzheimer's disease that could help protect the brain from damage and preserve cognitive function.

5 Jun 2025

Personalized exercise and coaching could improve health of people with neuromuscular diseases

While many people with neuromuscular diseases currently face a future without a cure, a new study finds that a personalized exercise and coaching program could improve their fitness and overall health.

4 Jun 2025

Two patients faced chemo. The one who survived demanded a test to see if it was safe.

JoEllen Zembruski-Ruple, while in the care of New York City's renowned Memorial Sloan Kettering Cancer Center, swallowed the first three chemotherapy pills to treat her squamous cell carcinoma on Jan. 29, her family members said. They didn't realize the drug could kill her.

4 Jun 2025

UC Irvine researchers uncover altered RNA processing in ALS

UC Irvine researchers conducted a study to better understand the molecular basis of amyotrophic lateral sclerosis (ALS), a neurodegenerative disorder in which patients lose the ability to move, becoming weak and wheelchair bound before dying because they can no longer breathe.

3 Jun 2025

Molecular stress makes old neurons vulnerable to neurodegenerative diseases

As the global population ages, the risk of developing neurodegenerative diseases such as dementia, Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS) continues to rise. But the molecular mechanisms behind the deterioration of brain cells have remained elusive.

2 Jun 2025

New discovery reveals immune molecule’s role in Alzheimer’s disease

A new way of thinking about Alzheimer's disease has yielded a discovery that could be the key to stopping the cognitive decline seen in Alzheimer's and other neurodegenerative diseases.

2 Jun 2025

Sleep disorders predict dementia risk years before diagnosis, study shows

Researchers analyzed health records from over 1 million people in Finland, Wales, and the UK to assess the long-term impact of sleep disorders on neurodegenerative diseases. They found that diagnosed sleep disorders can predict Alzheimer’s, Parkinson’s, and dementia risk up to 15 years before symptoms, regardless of genetic predisposition.

28 May 2025