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Streamlining CAR T cell production through in vivo therapeutic strategies

This review article highlights the transformative potential of in vivo CAR T cell therapy in addressing the limitations of traditional CAR T cell production.

5 Sep 2025

Smell loss emerges as the early behavioural sign of Alzheimer’s

Research reveals immune cells target brainstem nerves, linking smell loss to early Alzheimer's, offering potential for earlier diagnosis and intervention.

4 Sep 2025

Europa Biosite announces exclusive UK & Ireland partnership between Bio X Cell and Cambridge Bioscience

Europa Biosite is pleased to announce that Bio X Cell has appointed Cambridge Bioscience, a proud member of Europa Biosite, as its exclusive distributor for the United Kingdom and Ireland.

3 Sep 2025

CN Bio adds computational modeling capabilities to ADME services for enhanced bioavailability profiling

CN Bio, a leading provider of Organ-on-a-chip (OOC) Systems and solutions that accelerate drug discovery and development workflows, today announced the expansion of its Contract Research Services (CRS) with new PhysioMimix® computational modeling tools.

3 Sep 2025

Generative AI creates life-saving antibiotics from scratch

What if generative AI could design life-saving antibiotics, not just art and text? In a new Cell Biomaterials paper, Penn researchers introduce AMP-Diffusion, a generative AI tool used to create tens of thousands of new antimicrobial peptides (AMPs) - short strings of amino acids, the building blocks of proteins - with bacteria-killing potential.

2 Sep 2025

Single-cell transcriptomics reveals new players in liver regeneration

The liver is remarkable for its ability to regenerate after injury, yet when this process fails, acute liver failure (ALF) carries devastating outcomes.

2 Sep 2025

Nanostructures boost CRISPR delivery for genetic medicine

With the power to rewrite the genetic code underlying countless diseases, CRISPR holds immense promise to revolutionize medicine. But until scientists can deliver its gene-editing machinery safely and efficiently into relevant cells and tissues, that promise will remain out of reach.

2 Sep 2025

Compounds show significant inhibitory effects on α-glucosidase

Three of the compounds demonstrated significant inhibitory effects on α-glucosidase, a key enzyme in carbohydrate digestion. The findings could pave the way for new functional food ingredients targeting type 2 diabetes.

2 Sep 2025

Can honey protect your brain? Study reviews its potential against Alzheimer's

This review examined 27 preclinical studies on honey and Alzheimer’s disease, showing honey’s bioactive compounds counter oxidative stress, inflammation, and amyloid buildup. Despite promising lab results, no human trials exist, underscoring the need for clinical research.

1 Sep 2025

Why metformin could protect the brain by rewiring mitochondria

Metformin boosts human oligodendrocyte differentiation and myelination across stem-cell, organoid, and chimera models. The study links these effects to mitochondrial metabolic shifts, supporting its potential as a therapy for multiple sclerosis.

1 Sep 2025

Proteomic study reveals new drug targets in gastric signet ring cell carcinoma

Gastric signet ring cell carcinoma (GSRCC) is a distinct subtype of gastric cancer (GC) with unique epidemiological and pathogenic characteristics.

29 Aug 2025

Researchers identify genetic toolkit to reprogram cells into immune sentinels

An international team led by researchers at Lund University in Sweden has identified the molecular tools needed to reprogram ordinary cells into specialized immune cells.

29 Aug 2025

Disrupting protein quality control slows tumor growth in pediatric rhabdomyosarcoma

A new research paper was published in Volume 16 of Oncotarget on August 29, 2025, titled "In vivo manipulation of the protein homeostasis network in rhabdomyosarcoma."

29 Aug 2025

Clonogenic hepatocytes identified as engines of liver development

In a new study published in the Journal of Hepatology, researchers from the San Raffaele Telethon Institute for Gene Therapy (SR-Tiget) show that only 15–20% of hepatocytes in newborn mice - dubbed clonogenic hepatocytes - are responsible for generating over 90% of the adult liver mass.

29 Aug 2025

Probiotic enhances cholesterol drug efficacy but raises safety concerns at high doses

A recent study published in Engineering has shed light on the complex interactions between probiotics and drugs, particularly focusing on the effects of the probiotic Lacticaseibacillus paracasei Zhang (LCZ) on the cholesterol-lowering drug lovastatin.

28 Aug 2025

Regenerative strategy offers hope for women with pelvic organ prolapse

Pelvic organ prolapse (POP) is a disorder that primarily affects older women who have experienced multiple vaginal childbirths.

27 Aug 2025

New oral antiretroviral shows potential as long-acting HIV pre-exposure prophylaxis

A new HIV antiretroviral shows promise as a long-acting, oral prophylactic agent, according to a new study by Izzat Raheem, Tracy Diamond and colleagues from Merck & Co., Inc., Rahway, NJ, USA, published August 26th in the open-access journal PLOS Biology.

26 Aug 2025

Epstein-Barr virus protein enhances cancer gene activity in HPV-positive cervical cells

A new research paper was published in Volume 16 of Genes & Cancer on August 6, 2025, titled "Epstein-Barr virus nuclear antigen 1 upregulates Derlin1 and PSMD10 expression in HeLa cells."

22 Aug 2025

ATOX1 drives hepatocellular carcinoma progression through c-Myb and PI3K/AKT activation

Despite advancements in diagnostic and therapeutic strategies, hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality.

22 Aug 2025

New genome-wide CRISPR screening tool boosts natural killer cells to fight cancer

Natural killer (NK) cells became markedly better at killing cancer cells after scientists removed key gene targets identified through a new genome-wide CRISPR screening tool, according to new research from The University of Texas MD Anderson Cancer Center.

21 Aug 2025

in vivo News and Research

Streamlining CAR T cell production through in vivo therapeutic strategies

Smell loss emerges as the early behavioural sign of Alzheimer’s

Europa Biosite announces exclusive UK & Ireland partnership between Bio X Cell and Cambridge Bioscience

CN Bio adds computational modeling capabilities to ADME services for enhanced bioavailability profiling

Generative AI creates life-saving antibiotics from scratch

Single-cell transcriptomics reveals new players in liver regeneration

Nanostructures boost CRISPR delivery for genetic medicine

Compounds show significant inhibitory effects on α-glucosidase

Can honey protect your brain? Study reviews its potential against Alzheimer's

Why metformin could protect the brain by rewiring mitochondria

Proteomic study reveals new drug targets in gastric signet ring cell carcinoma

Researchers identify genetic toolkit to reprogram cells into immune sentinels

Disrupting protein quality control slows tumor growth in pediatric rhabdomyosarcoma

Clonogenic hepatocytes identified as engines of liver development

Probiotic enhances cholesterol drug efficacy but raises safety concerns at high doses

Regenerative strategy offers hope for women with pelvic organ prolapse

New oral antiretroviral shows potential as long-acting HIV pre-exposure prophylaxis

Epstein-Barr virus protein enhances cancer gene activity in HPV-positive cervical cells

ATOX1 drives hepatocellular carcinoma progression through c-Myb and PI3K/AKT activation

New genome-wide CRISPR screening tool boosts natural killer cells to fight cancer

Human iPSCs: A Full Guide to Advanced in Vitro Models and Applications eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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