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HIV drug stops disease progression in 25% of patients with fourth-line metastatic colorectal cancer

New clinical research shows that lamivudine, a reverse transcriptase inhibitor widely used in HIV therapy, stopped disease progression in 25% of patients with fourth-line metastatic colorectal cancer.

5 Apr 2022

Direction and magnitude of predictors of all-cause mortality following hospitalization with influenza, RSV, or SARS-CoV-2

Researchers performed a retrospective cohort study to identify predictors of mortality following hospitalization with influenza, respiratory syncytial virus, or SARS-CoV-2.

5 Apr 2022

Study reveals how pancreatic tumors program macrophages to construct fibrotic barriers

In the presence of pancreatic tumors, certain immune cells break down structural proteins into molecules that trigger the building of dense tissue, a known barrier to therapy, a new study finds.

4 Apr 2022

Animal study provides insights into how COVID-19 can lead to long-term pain

A new animal study has provided important insights into how COVID-19 SARS-CoV-2 - the virus responsible for COVID-19 - can lead to long-term pain.

4 Apr 2022

CBD and THC may be safe for use with opioid pain relievers, animal study suggests

Findings from a new animal study suggest that cannabidiol (CBD) and tetrahydrocannabinol (THC) might be safe for use with opioid pain relievers.

4 Apr 2022

Evidence SARS-CoV-2 undergoes ADAR-mediated A-to-I RNA editing in human cells

In a recent study published in the journal PLOS Genetics, researchers explored severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) ribonucleic acid (RNA) editing in host cells.

4 Apr 2022

Experimental siRNA therapeutic shows promise to reduce an important driver of heart disease risk

While there are effective therapies to reduce the risk of heart disease by lowering low-density lipoprotein (LDL), or "bad" cholesterol, and other lipids, to date there are no approved treatments to lower lipoprotein(a), a lesser-known driver of heart disease risk.

3 Apr 2022

Research demonstrates potential of local siRNA delivery as COVID antiviral therapy in the lung

Scientists develop a formulation for the pulmonary administration of siRNA. The aim was to suppress the replication of SARS-CoV-2.

3 Apr 2022

An in-depth analysis of pathogenesis of SARS-CoV-2 and therapeutic options for COVID-19

Scientists discuss the pathogenic characteristics of SARS-CoV-2 and available therapeutic interventions for treating COVID-19.

3 Apr 2022

Experimental siRNA therapy reduces a key driver of heart disease risk by up to 98%

Findings from a new Cleveland Clinic-led phase 1 trial show that an experimental "gene silencing" therapy reduced blood levels of lipoprotein(a), a key driver of heart disease risk, by up to 98%.

3 Apr 2022

Health and Social Care Secretary announces an extension on the cancer call for evidence to April 8

More people can share their experiences and views on how the country can lead the world on cancer care, as the Health and Social Care Secretary announces an extension on the cancer call for evidence to inform an ambitious 10-Year Cancer Plan.

1 Apr 2022

Groundbreaking collaborative work defines the risk of SARS-CoV-2 variants on immune protection

In a paper in the journal Nature, Los Alamos National Laboratory scientists Bette Korber, Hyejin Yoon, Will Fischer and James Theiler, among nearly 130 authors from institutions around the world, describe their groundbreaking collaborative work, "Defining the risk of SARS-CoV-2 variants on immune protection."

1 Apr 2022

Study shows significant increase in survival rates of extremely pre-term babies

A new study co-authored by a University of Rochester Medical Center researcher has found that the survival rates of extremely pre-term babies has increased significantly in the past decade.

1 Apr 2022

Investigational new drug may be safe for patients with mild cognitive impairment, dementia

A small, preliminary study of an investigational new drug being studied for mild cognitive impairment and mild dementia associated with Alzheimer's disease suggests it is safe and may be associated with improvements in executive function, thinking and memory skills.

31 Mar 2022

Therapeutic antibodies against filoviruses including Ebola and Marburg

Researchers discuss the development and structural characterization of therapeutic monoclonal antibodies targeting the surface glycoprotein of filoviruses.

31 Mar 2022

The mucosal antibody response to SARS-CoV-2

Researchers determine mucosal SARS-CoV-2-specific antibody levels and their neutralizing effect in pediatric and adult patients.

31 Mar 2022

GE-led team uses ultrasound to prevent or reverse Type-2 diabetes in preclinical models

Are we moving closer to the day when diabetes is no longer monitored and managed with blood sugar tests, insulin injections and drug treatments? A GE Research-led team, which includes The Feinstein Institutes for Medical Research, UCLA Samueli School of Engineering, Yale School of Medicine, and Albany Medical College, has demonstrated the ability to prevent or reverse the onset of diabetes in studies of three different preclinical model systems.

31 Mar 2022

Researchers discover a cell plasticity and inflammation driving druggable copper-signaling pathway

A new study identified mechanisms regulating immune cell plasticity to develop new therapeutics.

31 Mar 2022

Mosaic-8 RBD-nanoparticles show promise as a vaccine candidate for SARS-CoV-2 and potential sarbecoviruses spillovers

Researchers designed nanoparticles representing RBDs of the S protein of animal sarbecoviruses and SARS-CoV-2 to evaluate their potential as a pan-sarbecovirus vaccine candidate.

31 Mar 2022

Scientists create a biobank of 87 triple-negative breast cancer organoids

It's the cancer version of "mini me." Cold Spring Harbor Laboratory (CSHL) Professor David Spector, among others, has developed organoids, which are miniature, three-dimensional copies of cancers. Organoids can be derived from cancer or healthy cells.

30 Mar 2022

Therapeutics News and Research

HIV drug stops disease progression in 25% of patients with fourth-line metastatic colorectal cancer

Direction and magnitude of predictors of all-cause mortality following hospitalization with influenza, RSV, or SARS-CoV-2

Study reveals how pancreatic tumors program macrophages to construct fibrotic barriers

Animal study provides insights into how COVID-19 can lead to long-term pain

CBD and THC may be safe for use with opioid pain relievers, animal study suggests

Evidence SARS-CoV-2 undergoes ADAR-mediated A-to-I RNA editing in human cells

Experimental siRNA therapeutic shows promise to reduce an important driver of heart disease risk

Research demonstrates potential of local siRNA delivery as COVID antiviral therapy in the lung

An in-depth analysis of pathogenesis of SARS-CoV-2 and therapeutic options for COVID-19

Experimental siRNA therapy reduces a key driver of heart disease risk by up to 98%

Health and Social Care Secretary announces an extension on the cancer call for evidence to April 8

Groundbreaking collaborative work defines the risk of SARS-CoV-2 variants on immune protection

Study shows significant increase in survival rates of extremely pre-term babies

Investigational new drug may be safe for patients with mild cognitive impairment, dementia

Therapeutic antibodies against filoviruses including Ebola and Marburg

The mucosal antibody response to SARS-CoV-2

GE-led team uses ultrasound to prevent or reverse Type-2 diabetes in preclinical models

Researchers discover a cell plasticity and inflammation driving druggable copper-signaling pathway

Mosaic-8 RBD-nanoparticles show promise as a vaccine candidate for SARS-CoV-2 and potential sarbecoviruses spillovers

Scientists create a biobank of 87 triple-negative breast cancer organoids

Industry Focus eBook - Microbiome (1st edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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