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Peptidomimetics as a new strategy to modulate Aurora-A and combat cancer

A new approach to targeting a protein involved in cell division, which can misfunction in cancer, has revealed new insights into how it functions.

3 Dec 2024

Ketone metabolism redefines protein quality control in aging brains

Ketone bodies, produced by the body to provide fuel during fasting, have roles in regulating cellular processes and aging mechanisms beyond energy production. Research at the Buck Institute shows that ketone bodies can best be understood as powerful signaling metabolites affecting brain function in aging and Alzheimer's disease.

3 Dec 2024

Biocompatible liquid ink enables scalp-printed electrodes for non-invasive EEG

For the first time, scientists have invented a liquid ink that doctors can print onto a patient's scalp to measure brain activity. The technology, presented December 2 in the Cell Press journal Cell Biomaterials, offers a promising alternative to the cumbersome process currently used for monitoring brainwaves and diagnosing neurological conditions. It also has the potential to enhance non-invasive brain-computer interface applications.

3 Dec 2024

Overcoming challenges in developing cell therapies for heart disease

Pathways to new treatments for heart failure take time - as long as four decades for two now accepted therapies. So, new attempts to repair scar tissue in infarcted hearts using cells or cell products need more time to develop clinical therapies that can reduce risk of death from heart failure after a heart attack.

3 Dec 2024

Fas-p53 pathway drives metabolic dysfunction and obesity-linked insulin resistance

Researchers unveil Fas-p53 axis as a key regulator in adipocyte metabolism, linking it to obesity and insulin sensitivity through energy expenditure and inflammation pathways.

3 Dec 2024

New food-grade natural solution created for tackling obesity

As obesity rates continue to rise, many are turning to prescription medicines like Ozempic for weight loss. But with significant side effects, accessibility and cost issues, alternatives are needed.

2 Dec 2024

New algorithm identifies cells responsible for aggressive tumor growth

Cancer Research UK-funded scientists have unveiled the first computational algorithm capable of identifying which cell populations within a tumor drive aggressive growth.

2 Dec 2024

Pregnancy strengthens immune defense against flu, study finds

McGill University scientists have discovered that pregnancy may trigger a natural immunity to boost protection against severe flu infection.

2 Dec 2024

Study reveals pathways behind organ damage in severe COVID-19

New research published in the journal Proceedings of the National Academy of Sciences sheds light on the pathways that drive organ damage and death in severe COVID-19 and helps explain why survivors of the disease can experience long-term complications.

2 Dec 2024

New insights into how aging affects muscle cell regeneration

As muscles age, their cells lose the ability to regenerate and heal after injury. Now, Cornell University researchers have created the most comprehensive portrait to date of how that change, in mice, unfolds over time.

2 Dec 2024

Researchers develop organoid mimicking human fetal pancreas

Researchers from the Organoid group (previously Clevers group) at the Hubrecht Institute have developed a new organoid that mimics the human fetal pancreas, offering a clearer view of its early development.

2 Dec 2024

Study reveals how stem cells sense and respond to their environment

A new study from The Hospital for Sick Children (SickKids) and Institut Curie reveals how stem cells sense and respond to their environment, with implications for inflammatory bowel disease and colorectal cancer.

2 Dec 2024

Spatial transcriptomics uncovers new treatment paths for triple-negative breast cancer

Study uses spatial transcriptomics to map intratumoral heterogeneity and microenvironmental dynamics in triple-negative breast cancer (TNBC). The findings identify nine spatial archetypes and gene signatures linked to immunotherapy response and patient outcomes.

2 Dec 2024